A5050070650- Alzheimer's disease research and treatments
- Forensic Toxicology and Drug Analysis
- Opioid Use Disorder Treatment
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Graph theory and applications
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Calcium signaling and nucleotide metabolism
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Influenza Virus Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Monoclonal and Polyclonal Antibodies Research
- Functional Brain Connectivity Studies
- HIV, Drug Use, Sexual Risk
- Neurological Disease Mechanisms and Treatments
Yonsei University
2019-2025
Scripps Research Institute
2020-2024
We compared levels of Aβ by self-standard in plasma using an interdigitated microelectrode sensor to detect Alzheimer disease.
Alzheimer disease (AD) diagnosis is confirmed using a medley of modalities, such as the detection amyloid-β (Aβ) neuritic plaques and neurofibrillary tangles with positron electron tomography (PET) or appraisal irregularities in cognitive function examinations. Although these methods have been efficient confirming AD pathology, rising demand for earlier intervention during pathogenesis has led researchers to explore diagnostic potential fluid biomarkers cerebrospinal (CSF) plasma. Since CSF...
Amyloid-β (Aβ) oligomers are implicated in Alzheimer disease (AD). However, their unstable nature and heterogeneous state disrupts elucidation of explicit role AD progression, impeding the development tools targeting soluble Aβ oligomers. Herein parallel anti-parallel variants Aβ(1-40) dimers were designed synthesized, pathogenic properties models characterized. Anti-parallel induced cognitive impairments with increased amyloidogenesis cytotoxicity, this dimer was then used a screening...
New psychoactive substance (NPS) opioids have proliferated within the international drug market. While synthetic are traditionally composed of fentanyl analogues, benzimidazole-derived isotonitazene and its derivatives current NPS concern. Hence, in this study, we implement immunopharmacotherapy wherein antibodies produced with high titers nanomolar affinity to multiple (BNO). Notably, these blunt physiological repercussions from BNO exposure, which was observed through antinociception,...
The opioid epidemic is a global public health crisis that has failed to abate with current pharmaceutical treatments. Moreover, these FDA-approved drugs possess numerous problems such as adverse side effects, short half-lives, abuse potential, and recidivism after discontinued use. An alternative treatment model for use disorders immunopharmacotherapy, where antibodies are produced inhibit illicit substances by sequestering the drug in periphery. Immunopharmacotherapeutics against heroin...
Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming major public health risk. Due to the wide variety SCs, broadly neutralizing antibodies generated by active immunization present an intriguing pathway combat cannabinoid use disorder. Here, we probed hapten design for antibody affinity and cross reactivity against two classes SCs. Of 10 haptens screened, 3 vaccine groups revealed submicromolar IC50, each targeting 5–6 compounds in our panel 22...
Phospholipase D3 (PLD3) and D4 (PLD4) are endolysosomal exonucleases of ssDNA ssRNA that regulate innate immunity. Polymorphisms these enzymes correlated with numerous human diseases, including Alzheimer's, rheumatoid arthritis, systemic sclerosis. Pharmacological modulation immunoregulatory proteins may yield novel immunotherapies adjuvants. A previous study reported a high-throughput screen (N = 17,952) discovered PLD3-selective activator inhibitor, as well nonselective but failed to...
Abstract Amyloid‐β (Aβ) oligomers are implicated in Alzheimer disease (AD). However, their unstable nature and heterogeneous state disrupts elucidation of explicit role AD progression, impeding the development tools targeting soluble Aβ oligomers. Herein parallel anti‐parallel variants Aβ(1–40) dimers were designed synthesized, pathogenic properties models characterized. Anti‐parallel induced cognitive impairments with increased amyloidogenesis cytotoxicity, this dimer was then used a...
Phospholipase D3 (PLD3) and D4 (PLD4) are endolysosomal exonucleases of ssDNA ssRNA that regulate innate immunity. Polymorphisms these enzymes correlated with numerous human diseases, including Alzheimer’s, rheumatoid arthritis, systemic sclerosis. Pharmacological modulation immunoregulatory proteins may yield novel immunotherapies adjuvants. A previous study reported a high-throughput screen (N = 17,952) discovered PLD3-selective activator inhibitor, as well nonselective but failed to...