A5016512966- NF-κB Signaling Pathways
- Ginger and Zingiberaceae research
- Healthcare and Venom Research
- Protease and Inhibitor Mechanisms
- Peroxisome Proliferator-Activated Receptors
- melanin and skin pigmentation
- Cell death mechanisms and regulation
- Skin Protection and Aging
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Bioactive natural compounds
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Toxin Mechanisms and Immunotoxins
- Pancreatic function and diabetes
- Chemotherapy-induced organ toxicity mitigation
- Bone health and treatments
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- Marine Sponges and Natural Products
- Natural Antidiabetic Agents Studies
Wonkwang University
2015-2024
Jeonbuk National University
2005-2008
Pain and Rehabilitation Medicine
2007
OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function. Because of central role NF-κB in cytokine-mediated pancreatic β-cell damage, we postulated that SIRT1 might work damage models. RESEARCH DESIGN AND METHODS—RINm5F (RIN) cells or isolated rat islets were treated interleukin-1β interferon-γ. was activated by resveratrol, pharmacological activator, ectopic...
In our previous study, we clearly demonstrated the roles of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6, subsequent reactive oxygen species (ROS) generation on pathogenesis cisplatin ototoxicity in vitro vivo . ROS cisplatin-treated HEI-OC1 auditory cells was also correlated with changing mitochondrial membrane potential. However, NADPH oxidase cisplatin-induced have not been fully elucidated. Herein, immunohistochemical studies that...
Objective. MMP is a key enzyme in the degradation of extracellular matrices, and its expression plays important roles inflammatory diseases. Cordycepin (3′-deoxyadenosine), bioactive compound Cordyceps militaris, has been shown to exhibit many pharmacological activities, such as anti-cancer, anti-inflammatory anti-infection activities. In this study, we aimed at inhibitory effect cordycepin on IL-1β-induced MMP-1 MMP-3 well molecular basis using RA synovial fibroblasts (RASFs).
Objectives: In the past few decades, use of natural compounds, such as flavonoids, anti-inflammatory agents has gained much attention. Our current study focuses on preventive effects quercetin, apigenin, and luteolin cytokine-induced β-cell damage. Methods: Pancreatic β-cells or islets were treated with cytokine mixtures in presence absence flavonoids inhibitory effect against toxicity was determined. Results: Treatment RINm5F (RIN) rat insulinoma cells interleukin 1β (IL-1β) interferon γ...
Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin through their damaging effect on cellular constituents. However, the origins of have not been fully elucidated. We investigated that generation replicative senescent fibroblasts is generated by modulation phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction PTEN protein, which dephosphorylates PIP3, was responsible for maintaining high level PIP3 cells consequently...
Diallyl disulfide (DADS) induced apoptosis through the caspase-3 dependent pathway in leukemia cells was earlier reported from this laboratory. In study, we investigated involvement of Ca(2+) DADS-induced apoptotic cell death HCT-15, human colon cancer line. DADS elevation cytosolic by biphasic pattern; rapid peak at 3 min and following slow sustained till h after addition DADS. Production H(2)O(2) also observed with its value 4 h. Apoptotic pathways including sequence activation,...
NF-κB activation has been implicated as a key signaling mechanism for pancreatic β-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which reported to inhibit inflammatory response suppressing pathway. Therefore, we isolated sulfuretin from verniciflua and evaluated if could cytokine- or streptozotocin-induced Rat insulinoma RINm5F cells rat islets were treated with IL-1β IFN-γ induce cytotoxicity. Incubation resulted in significant reduction...
Previous studies showed that exposure to<i>Vibrio vulnificus</i> cytolysin (VVC) caused characteristic morphologic changes and dysfunction of vascular structures in lung. VVC cytotoxicity for mammalian cells culture acted as a permeability factor. In this study, the underlying mechanisms VVC-induced was investigated on ECV304 cell, human endothelial cell line. When were exposed to 0.4 hemolytic units (HU) VVC, consecutive apoptotic events observed; elevation superoxide anion...
Docosahexaenoic acid (DHA) is an omega-3 fatty that considered to have applications in cancer prevention and treatment. The beneficial effects of DHA against metastasis are well established; however, the mechanisms underlying these breast not clear. Cell invasion critical for neoplastic metastasis, involves degradation extracellular matrix by metalloproteinase (MMP)-9. present study investigated inhibitory effect on MMP-9 expression cell induced 12-O-tetradecanoylphorbol-13-acetate (TPA)...
Abstract Echinacea purpurea (L.) Moench (EP), a medicinal plant native to North America, is now cultivated in various regions including Europe. With increasing popularity of Korea recently, human clinical trial was conducted evaluate immune‐enhancing efficacy and safety EP 60% ethanolic extract (EPE) Koreans. Eighty volunteers were recruited for this randomized, double‐blind, placebo‐controlled trial. They randomly divided into two groups given either daily dose 200 mg EPE or placebo. All...