A5102997013- Protease and Inhibitor Mechanisms
- melanin and skin pigmentation
- Natural product bioactivities and synthesis
- Skin Protection and Aging
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Bone health and treatments
- Marine Sponges and Natural Products
- Food Quality and Safety Studies
- Genomics, phytochemicals, and oxidative stress
- Phytochemical compounds biological activities
- Antibiotic Resistance in Bacteria
- Cell Adhesion Molecules Research
- Education and Learning Interventions
- Galectins and Cancer Biology
- Pharmacological Effects of Medicinal Plants
- Cytokine Signaling Pathways and Interactions
- Educational Systems and Policies
- Healthcare Education and Workforce Issues
- Dermatology and Skin Diseases
- Oral microbiology and periodontitis research
- Phytochemicals and Antioxidant Activities
- Mast cells and histamine
- Diverse Approaches in Healthcare and Education Studies
Wonkwang University
2012-2023
Jeonbuk National University
2011-2023
Seoul National University Hospital
2018
Kangwon National University
2009-2012
Seoul Women's University
2005-2006
Chungbuk National University
2005
Platycodon grandiflorum is a flowering plant that used in traditional medicine for treating pulmonary and respiratory disorders. It exerts various pharmacological effects, including immunomodulatory anti-cancer activities. The purpose of this study was to confirm the vitro vivo immune-enhancing effects P. extract (PGE) on splenocytes isolated from cyclophosphamide (CP)-induced immunosuppressed rats.For analysis, were treated with PGE at doses along CP. Cell viability measured by WST-1 assay,...
Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane] is an isothiocyanate found in some cruciferous vegetables, especially broccoli. has been shown to display anti-cancer properties against various cancer cell lines. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays important role invasion. In this study, we investigated effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and invasion MCF-7 cells....
Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin through their damaging effect on cellular constituents. However, the origins of have not been fully elucidated. We investigated that generation replicative senescent fibroblasts is generated by modulation phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction PTEN protein, which dephosphorylates PIP3, was responsible for maintaining high level PIP3 cells consequently...
Docosahexaenoic acid (DHA) is an omega-3 fatty that considered to have applications in cancer prevention and treatment. The beneficial effects of DHA against metastasis are well established; however, the mechanisms underlying these breast not clear. Cell invasion critical for neoplastic metastasis, involves degradation extracellular matrix by metalloproteinase (MMP)-9. present study investigated inhibitory effect on MMP-9 expression cell induced 12-O-tetradecanoylphorbol-13-acetate (TPA)...
Decursin, a coumarin compound, was originally isolated from the roots of Angelica gigas almost four decades ago, and it found to exhibit cytotoxicity against various types human cancer cells anti-amnesic activity in vivo through inhibition AChE activity. However, anti-skin photoaging effects decursin have not been reported date. In present study, we investigated inhibitory on expression matrix metalloproteinase (MMP)-1 MMP-3 dermal fibroblast (HDF) cells. Western blot analysis real-time PCR...
Saussurea lappa (SL) has been used as a traditional herbal medicine to treat abdominal pain and tenesmus, suggested possess various biological activities, including anti-tumor, anti-ulcer, anti-inflammatory, anti-viral, cardiotonic activities. The effect of SL on breast cancer metastasis, however, is unknown. Cell migration invasion are crucial in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, major component cell invasion. viability was...
Sophorae Flos (SF) is a composite of flowers and buds Styphnolobium japonicum (L.) Schott has been used in traditional Korean Chinese medicine for the treatment hemostasis inflammation. Previous studies reported that SF possesses anti-obesity properties, as well anti-allergic, anti-proliferative, anti-inflammatory activities. However, effect bone resorption not studies. In this study, we examined potential extract (SFE) to inhibit receptor activator NF-κB ligand (RANKL) -induced osteoclast...
Cancer cell invasion is crucial for metastasis. A major factor in the capacity of cancer activation matrix metalloproteinase‑9 (MMP‑9), which degrades extracellular matrix. Salvia miltiorrhiza has been used as a promotion blood circulation to remove stasis. Numerous previous studies have demonstrated that S. extracts (SME) decrease lipid levels and inhibit inflammation. However, mechanism behind effect SME on breast not identified. The inhibitory effects 12‑O‑tetradecanoylphorbol‑13‑acetate...
Bruton's agammaglobulinemia tyrosine kinase (BTK) is an important cytoplasmic involved in B‑lymphocyte development, differentiation, and signaling. Activated protein C (PKC), turn, induces the activation of mitogen‑activated (MAPK) signaling, which promotes cell proliferation, viability, apoptosis, metastasis. This effect associated with nuclear factor‑κB (NF‑κB) activation, suggesting anti‑metastatic BTK inhibitors on MCF‑7 cells that leads to downregulation matrix metalloproteinase (MMP)‑9...
Fisetin is a flavonoid found in plants and has been reported to be effective various human diseases. However, the mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated protective fisetin regarding UVA-induced dermal fibroblasts (HDFs) epidermal keratinocytes (HEKs) damages. showed cytoprotective effect against UVA irradiation suppressed matrix metalloproteinases (MMPs), MMP-1, MMP-3 expression. addition, was rescued, which decreased mRNA...
Ultraviolet B (UVB) radiation induces photoageing by upregulating the expression of matrix metalloproteinases (MMPs) in human skin cells. Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which active component oats. Although anti-inflammatory, anti-atherosclerotic and antioxidant effects have been reported, antiphotoageing DHAvD are yet be understood. In this study, we investigated inhibitory on UVB-induced production reactive oxygen species (ROS)...
The rhizome of Alisma orientale (Alismatis rhizome) has been used in Asia for promoting diuresis to eliminate dampness from the lower-jiao and expel heat. In this study, an ethanol extract (AOE) was prepared its effects on adipocyte differentiation OP9 cells were investigated. Treatment with AOE a medium 5 days resulted dose-dependent inhibition lipid droplet formation cells. Furthermore, significantly inhibited by downregulating expression master transcription factor adipogenesis,...
Decursin, a coumarin compound, was first isolated from the roots of Angelica gigas almost four decades ago. It found to exhibit cytotoxicity against various human cancer cells and possess anti-amnesic activity in vivo through inhibition AChE activity. However, effect decursin on breast invasion is unknown. Matrix metalloproteinase-9 (MMP-9) known be an important factor for cell invasion. Therefore, this study, we investigated inhibitory 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced...
This study was performed to assess the antioxidant activities and whitening effects of Agrimonia pilosa Ledeb on melanin synthesis. The water extracts were examined by in vitro mushroom tyrosinase assay B16BL6 melanoma cells. We assessed inhibitory effect extract expression melanogenic enzyme proteins including tyrosinase, tyrosinase-related protein 1 (TRP-1) tyrosinaserelated 2 (TRP-2) Inhibitory onto free radical generation determined measuring DPPH hydroxyl scavenging activitie. Our...
Metastatic cancers spread from their site of origin (the primary site) to other parts the body. Matrix metalloproteinase-9 (MMP-9), which degrades extracellular matrix, is important in metastatic as it plays a major role cancer cell invasion. The present study examined inhibitory effect an ethanol extract Peucedanum japonicum Thunb. (PJT) on MMP-9 expression and invasion MCF-7 breast cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Western blot analysis, gelatin zymography,...
The flower of chrysanthemum, used worldwide as a medicinal and edible product, has shown various bioactivities, such anti-inflammatory, antioxidant, anti-tumorigenic, hepatoprotective activities, well cardiovascular protection. However, the effect Chrysanthemum morifolium Ramat. on regulation osteoclast differentiation not yet been reported. In this study, we aimed to investigate inhibitory water extract (CME) RANKL-induced in mouse bone marrow-derived macrophages (BMMs). Bone (BMMs)...
Periodontitis is a Gram-negative bacterial infectious disease. Numerous inflammatory cytokines, including interleukin-1
The constituents of Peucedanum japonicum Thunb. (PJ) exhibit biological and pharmacological activities, including anti-obesity, anti-oxidant anti-allergic activities. aim the present study was to examine in vitro effects PJ RANKL-induced signaling pathways, which determine osteoclast differentiation. ethanol extract (PEE) exhibited anti-osteoporotic activity by disrupting phospholipase C (PLC)-Ca2+-c-Fos/cAMP response element-binding protein (CREB)-nuclear factor activated T cells,...
Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion and metastasis. Matriptase is highly expressed in breast cancer associated with poor patient outcome. However, cellular mechanism by which matriptase mediates remains unknown. The present study aimed to determine role protein kinase C (PKC)‑mediated metastasis MCF‑7 human cells. small interfering RNA‑mediated knockdown significantly attenuated...
본 연구에서는 정공피 물 추출물의 미백 효과를 확인하기 위하여 항산화 효능을 검증하였고, 멜라닌 생성의 첫 단계인 tyrosinase 활성, mouse melanoma B16BL6 세포 생존율 및 TRP-1, TRP-2 mRNA 발현 정도를 측정하였다. 추출물은 DPPH hydroxy 라디칼 소거 작용을 통하여 높은 나타내었고, tyrosinase, TRP-2의 활성을 효과적으로 억제하는 것을 확인하였다. 이는 추출물이 직접적으로 세포의 단백질의 저해시킴으로써 생성을 억제하는데 효과적임을 의미한다. 결론적으로 활성과 효과가 우수하여 기능성 화장품의 천연 소재로서 활용 가능성이 매우 것으로 판단된다.
Protaetia brevitarsis (PB)-derived bioactive substances have been used as food and medicine in many Asian countries because of their antioxidant, antidiabetic, anti-cancer, hepatoprotective properties. However, the effect PB extracts (PBE) on osteoclast differentiation is unclear. In this study, we investigated PBE RANKL-induced osteoclastogenesis mouse bone marrow-derived macrophages (BMMs). To investigate cytotoxicity PBE, viability BMMs was confirmed via MTT assay. Tartrate-resistant acid...