A5100613172- Food Quality and Safety Studies
- Insect and Pesticide Research
- Healthcare and Venom Research
- Protein Hydrolysis and Bioactive Peptides
- Nutrition, Health and Food Behavior
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Biochemical effects in animals
- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Garlic and Onion Studies
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Immune Cell Function and Interaction
- Skin Protection and Aging
- T-cell and B-cell Immunology
- Muscle metabolism and nutrition
- Bee Products Chemical Analysis
- Phytochemistry and Biological Activities
- Bioactive Compounds in Plants
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Animal Genetics and Reproduction
Hanseo University
2009-2024
National Renewable Energy Laboratory
2024
Lawrence Livermore National Laboratory
2024
Kyungsung University
1998-2023
Argonne National Laboratory
2022-2023
Hoseo University
2022
National Cancer Institute
2012-2022
Center for Cancer Research
2019-2022
Lawrence Berkeley National Laboratory
2022
National Institutes of Health
2019-2021
Restriction digestion fragments of DNAs extracted from 14 representative strains Saccharomonospora azurea, "Saccharomonospora caesia," cyanea, glauca, and viridis six "Saccharomonospora"-like isolates were separated by electrophoresis, Southern blotted onto nylon membranes, hybridized using two rRNA gene probes cloned Streptomyces griseus subsp. KCTC 9080. The following four restriction endonucleases used: Bam HI, Sal I, Pvu II, Xho I. resultant five ribotype patterns considered species...
// Chae Hwa Kwon 1,* , Hye Ji Park Jin Choi 1 Ja Rang Lee Kyung Kim Hong-jae Jo 2 Hyun Sung Nahmgun Oh Geun Am Song 3 and Do Youn Department of Pathology, Pusan National University Hospital School Medicine, BioMedical Research Institute, Hospital, Seo-Gu, Busan, Korea Surgery, Internal * These authors have contributed equally to this work Correspondence to: Park, email: Keywords : colorectal cancer, snail, serpinA1, prognosis, fibronectin Received December 16, 2014 Accepted April 10, 2015...
In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on pheochromocytoma cell line (PC12) was investigated. The active component purified determined to be 2,4-di-tert-butylphenol. antioxidant capacity 2,4-di-tert-butylphenol measured by using 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine effects amyloid-beta peptide (Aβ1-42)-induced learning memory impairment in mice, vivo behavioral...
Targeted cancer therapy with natural compounds is more effective than nontargeted therapy. Nobiletin a flavonoid derived from citrus peel that has anticancer activity. Cluster of differentiation 36 (CD36) member the class B scavenger receptor family involved in importing fatty acids into cells. CD36 plays role tumor angiogenesis by binding to its ligand, thrombospondin-1 (TSP-1), and then interacting transforming growth factor beta 1 (TGFβ1). implicated metastasis through roles acid...
Ultraviolet-B (UVB) irradiation has been demonstrated to produce reactive oxygen species (ROS) in the cells and skin, which induces synthesis of matrix metalloproteinases (MMPs), causing skin photoaging. Using human fibroblast HS68 cell line present study, we investigated photoprotective effects aucubin from Eucommia ulmoides. Pretreatment with significantly inhibited production MMP-1 by 57% when compared UVB-irradiated cells. Additionally, senescence-associated beta-galactosidase (SA...
Purpose Both telomere length and mitochondrial function are accepted as reflective indices of aging. Recent studies have shown that dysfunction may influence impaired biogenesis function. However, there has been no study regarding the possible association between in humans. Therefore, purpose was to identify any relationships Methods The present included 129 community-dwelling, elderly women. leukocyte DNA copy number were measured using a quantitative real-time polymerase chain reaction...
Collagen hydrolysate (CH) has been reported to exhibit a positive effect on bone. In the present study, in vitro effects of CH (<3 kDa) were examined and vivo experiments confirmed ovariectomized (OVX) rats. Bone mineral density (BMD) was by DXA analysis. Scanning electron microscopic analysis quantitative 3D-color backscattered electrons imaging performed lumbar vertebrae. increased osteoblastic cell proliferation alkaline phosphatase activity dose-dependent manner. synthesis collagen,...
This study was performed to identify safe and more effective acetylcholinesterase (AChE) inhibitors in the treatment of Alzheimer's disease. The total methanol extract Citrus junos had a significant inhibitory effect on AChE vitro. By sequential fractionation C.junos, active component finally identified as naringenin. Naringenin inhibited activity dose-dependent manner. In this study, we also evaluated anti-amnesic naringenin, major flavanone constituent isolated from C. junos, vivo using...
We screened 50 Korean traditional natural plants to measure the activation effect on choline acetyltransferase and attenuation of scopolamine-induced amnesia. The methanolic extracts from Zizyphus jujuba among tested plants, showed highest activatory (34.1%) in vitro. By sequential fractionation jujuba, active component was finally identified as cis-9-octadecenoamide (oleamide). After isolation, oleamide a 65% effect. Administration (0.32%) mice significantly reversed memory and/or cognitive...
To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective against oxidative stress-induced cytotoxicity PC12 cells. Administration also significantly reversed amyloid beta peptide (Abeta)-induced impaired performance a Y-maze test. Taken altogether, results reported here suggest that further investigation is warranted influence on pathways...
ABSTRACT Recombinant formate dehydrogenase from the acetogen Clostridium carboxidivorans strain P7 T , expressed in Escherichia coli shows particular activity towards NADH-dependent carbon dioxide reduction to due relative binding affinities of substrates and products. The enzyme retains over 2 days at 4°C under oxic conditions.
5-Hydroxymethylfurfural (5-HMF) is a common Maillard reaction product; the occurs during heat-processing and preparation of many types foods beverages. Although 5-HMF has been proposed to have harmful effects, recently, its beneficial including antioxidant, cytoprotective antitumor effects become increasingly apparent. It was found recently that chloroform extract aged black garlic shows antiinflammatory properties when administered human umbilical vein endothelial cells (HUVECs). This study...
Ultraviolet (UV) irradiation generates reactive oxygen species (ROS) in the cells, which induces cellular senescence and photoaging. The present study investigated protective effects of garlic on photo-damage UVB-exposed human keratinocytes, HaCaT cells. An vitro cell free system was used to examine scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals nitric oxide (NO). effect extract ROS formation, MMP-1 protein mRNA expressions, cytokines such as interleukin (IL)-1β IL-6,...
Instant coffee mixes that contain sugar and non-dairy creamer account for 80–90% of the total market in Korea. The objective this study was to investigate relationship between consumption obesity Korean women. We included 5995 women who participated a health screening examination at National Cancer Center 2007 2016. Daily use evaluated using 106-item food frequency questionnaire. Obesity assessed by body mass index (BMI), abdominal waist circumference (WC). A multiple logistic regression...
Although body mass index (BMI) is the most widely accepted parameter for defining obesity, recent studies have indicated a unique set of patients who exhibit normal BMI and excess fat (BF), which termed as weight obesity (NWO). Increased BF an established risk factor atherosclerosis. However, it unclear whether NWO subjects already higher degree vascular inflammation compared to lean (NWL) subjects; moreover, association with in largely unknown. NWL (n = 82 each group) without any history...
Opuntia ficus-indica var. saboten (OFS) has been used in traditional medicine for centuries to treat several illnesses, including diabetes. However, detailed mechanisms underlying hypoglycemic effects remain unclear. In this study, the mechanism activity of OFS was evaluated using vitro and vivo systems. treatment inhibited α-glucosidase intestinal glucose absorption assessed by Na⁺-dependent uptake brush border membrane vesicles. AMP-activated protein kinase (AMPK) is widely recognized as...
UV exposure is associated with oxidative stress and the primary factor in skin photoaging. UV-induced reactive oxygen species (ROS) cause up-regulation of metalloproteinase (MMPs) degradation dermal collagen elastic fibers. Garlic its components have been reported to exert antioxidative effects. The present study investigated protective effect garlic on photoaging MMPs regulation hairless mice. was supplemented diet, Skh-1 mice were exposed irradiation five days/week for eight weeks. Mice...
The anti-diabetic and antioxidative effect of amaranth grain (AG) its oil fraction (AO) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into four groups after induction STZ-diabetes: normal control; diabetic-AG supplement (500 g kg(-1) diet); diabetic-AO (100 diet) fed experimental diets for 3 weeks. Serum glucose, insulin, activities serum marker enzymes liver function cytosolic antioxidant measured. AG AO significantly decreased the glucose...
The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration TP significantly reversed scopolamine-induced retention deficits both step-through passive avoidance spontaneous alternation behavior tasks. Furthermore, exhibited a dramatic inhibitory acetylcholinesterase activity. This finding suggests that might be useful the treatment Alzheimer's disease.
Several nanoporous aluminophosphates (AlPOs) have been used to analyze the effect of pore diameter on hydrogen adsorption characteristics. The heat and capacity per unit micropore volume increase with decreasing size. AlPOs smaller micropores favorably adsorb at relatively low pressures. This work demonstrates that small size large are beneficial for high uptake.
Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, pathological characteristics of GISTs have not been made clear yet.Furthermore, concrete diagnostic criteria malignant are still uncertain.We collected pathology reports 1,227 from 38 hospitals Korea between 2003 2004 evaluated efficacy NIH AFIP classification schemes as well prognostic factors among pathologic findings.The incidence is about 1.6 to 2.2 patients per...
This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d treatment. After administering TMT for 3 d, each mouse performed Y-maze passive avoidance tests check immediate working performance function. The results showed that administration attenuated TMT-induced injury decline activity mice. suggests might be useful...