A5100661922- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Acute Myeloid Leukemia Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Lymphocytic Leukemia Research
- Diabetes Management and Research
- Peptidase Inhibition and Analysis
- SARS-CoV-2 detection and testing
- Cancer Risks and Factors
- Bacterial Genetics and Biotechnology
- Hematopoietic Stem Cell Transplantation
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Cervical Cancer and HPV Research
- Multiple Myeloma Research and Treatments
- Diabetes Treatment and Management
- Chronic Myeloid Leukemia Treatments
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Histone Deacetylase Inhibitors Research
Kangdong Sacred Heart Hospital
2017-2024
Hallym University
2017-2024
Seoul National University Bundang Hospital
2024
Yeungnam University
2010-2023
Yeungnam University College
2010-2023
Yeungnam University Medical Center
2007-2023
Korea University
2017-2022
Celltrion (South Korea)
2021
Hallym University Sacred Heart Hospital
2020
Yonsei University
2012-2019
The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between TyG and arterial stiffness in adults. Therefore, we evaluated relationship measured based on brachial ankle pulse wave velocity (baPWV) Korean adults.A total 3587 subjects were enrolled this study. Anthropometric cardiovascular risk factors measured. was calculated ln[fasting triglycerides(mg/dl) × fasting...
The triglyceride glucose (TyG) index has been considered a simple surrogate marker of insulin resistance. However, few studies have investigated the relationship between TyG and coronary artery calcification (CAC). Thus, we CAC in healthy Korean adults. In total, 4319 participants who underwent cardiac computed tomography (CT) health promotion center were enrolled. Anthropometric profiles multiple cardiovascular risk factors measured. was calculated as ln [fasting triglycerides (mg/dL) ×...
Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance which is well-known pathogenic factor in nonalcoholic fatty liver disease (NAFLD).However, few studies have investigated relationship between TyG and NAFLD.Thus, we NAFLD effectiveness compared with homeostasis model assessment (HOMA-IR) identifying Korean adults.Methods: Participants 4,986 who underwent ultrasonography health promotion center were enrolled.The was...
Abstract The immediate and well‐documented benefits of carbohydrate restriction include improved glycemic control in individuals with diabetes mellitus. Starch, a significant source carbohydrates, is categorized as rapidly digestible, slowly or resistant starch (RS). RS, which non‐viscous fermentable fiber, has shown promise animal studies for antidiabetic effects by improving glucose metabolism. Although the exact mechanism RS affects metabolism remains unclear, it expected to positively...
Neutralizing antibodies can reduce SARS-CoV-2 cellular entry, viral titers, and pathologic damage. CT-P59 (regdanvimab), a neutralizing monoclonal antibody, was examined in 2 randomized, double-blind, placebo-controlled, single ascending dose, Phase I studies.In study 1.1, healthy adults were sequentially enrolled to receive 10, 20, 40, or 80 mg/kg placebo. In 1.2, adult patients with mild infection Primary objectives of both studies safety tolerability up day 14 after infusion. Secondary...
Although body mass index (BMI) is the most widely accepted parameter for defining obesity, recent studies have indicated a unique set of patients who exhibit normal BMI and excess fat (BF), which termed as weight obesity (NWO). Increased BF an established risk factor atherosclerosis. However, it unclear whether NWO subjects already higher degree vascular inflammation compared to lean (NWL) subjects; moreover, association with in largely unknown. NWL (n = 82 each group) without any history...
The cardio-ankle vascular index (CAVI) reflects overall arterial stiffness from the aorta to ankle, independent of blood pressure. We aimed investigate association fat burden assessed by visceral adipose tissue (VAT), subcutaneous (SAT) and epicardial (EAT) with CAVI in an asymptomatic population.A total 260 Korean individuals who had CAVI, abdominal computed tomography (CT) coronary CT were evaluated retrospectively. VAT, SAT, EAT SAT VAT ratio (SVR) measured for correlation CAVI.Different...
The cardio-ankle vascular index (CAVI) is an of arterial stiffness. We investigated the association CAVI with severity coronary artery calcification (CAC) and stenosis by computed tomography angiography (CTA) in asymptomatic population.A total 549 Korean individuals who underwent CTA were analyzed retrospectively. CAC measured assessed for correlation CAVI.The degree demonstrated a significant (r= 0.187, p<0.001 r= 0.212, score stenosis, respectively). After adjustment potential confounders,...
Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD). Recently, atherogenic index of plasma (AIP) has been proposed as novel predictive marker CVD, and few cross sectional studies have demonstrated relationship between AIP coronary artery disease. The present study investigated the association progression calcification (CAC) in Korean adults without CVD. A total 1124 participants who had undergone CAC measurement at least twice by multi-detector computed tomography (CT)...
This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according obesity phenotypes.
Thyroid dysfunction has been implicated as a potential pathophysiological factor in glucose homeostasis and insulin resistance (IR). This study aimed to identify the correlation between thyroid IR. We used data from sixth Korean National Health Nutrition Examination Survey evaluate total of 5727 participants. The triglyceride (TyG) index model assessment (HOMA-IR) were calculated represent Correlation analysis was performed log-transformed TSH (LnTSH) free T4 significantly correlated with...
Cardiovascular disease is a leading cause of death in postmenopausal women, and nonalcoholic fatty liver (NAFLD) has been known to be associated with cardiovascular disease. However, little information regarding the relationship between NAFLD coronary artery calcification (CAC) women available. The aim this study was investigate association CAC women.Among 4,377 participants who underwent cardiac computed tomography health promotion center, 919 were enrolled. Anthropometric profiles multiple...
The plasma atherogenic index (AIP) has been suggested as a useful independent predictor of cardiovascular diseases (CVDs) in high CV risk patients. We investigated the association between AIP and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) healthy adults. A total 3468 subjects without any metabolic or were enrolled. Anthropometric factors measured. was defined base 10 logarithm ratio concentration triglycerides to high-density lipoprotein-cholesterol. Subjects...
Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the arterial stiffness in healthy adults. A total of 2932 subjects were enrolled this study. Anthropometric biochemical profiles including measured. The was measured using brachial-ankle pulse wave velocity (baPWV). Serum levels classified into quartiles baPWV values gradually increased with each quartile. Multiple regression analysis showed that...
Abstract The coiled-coil (CC) domain is a very important structural unit of proteins that plays critical roles in various biological functions. major oligomeric state CCs dimer, which can be either parallel or antiparallel. orientation each α-helix CC for the molecular function CC-containing proteins, but cannot determined easily by sequence-based prediction. We developed biochemical method assessing differences between and antiparallel homodimers named it ACCORD ( A ssessment tool...
Diabetic kidney disease (DKD) is one of the major microvascular complications diabetes and leading cause end-stage renal (ESRD) risk factors cardiovascular (CVD).
Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated relationship between TyG and fibrosis subjects with NAFLD. Thus, we Korean adults. Methods: In total, 5158 participants who underwent ultrasonography health promotion center were enrolled. Anthropometric profiles multiple metabolic risk...
We investigated the clinical outcome of bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL) who received rituximab-based therapy.A total 567 consecutive newly diagnosed DLBCL treated rituximab-CHOP (RCHOP) between November 2001 and March 2010 were included current study. All underwent a BM study at initial staging characteristics prognosis these or without analyzed retrospectively.The cohort patients. The overall incidence was 8.5%. With median follow-up...
Purpose: To evaluate the events leading to a diagnosis of glaucoma.Methods: Medical records 484 subjects (223 women, 261 men; mean age, 55.3 years) who visited glaucoma clinic without previous were reviewed.Events classified into: 1) glaucoma-related symptoms, such as ocular pain accompanied by intraocular pressure elevation or visual disturbance other abnormalities except glaucoma, 2) examination an ophthalmologist for 3) routine health examination, 4) patient request due family history...