A5100356996- Nutritional Studies and Diet
- Nitric Oxide and Endothelin Effects
- Immune Response and Inflammation
- Hearing, Cochlea, Tinnitus, Genetics
- Environmental DNA in Biodiversity Studies
- Employee Performance and Leadership
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Dental materials and restorations
- Renal Diseases and Glomerulopathies
- Ginseng Biological Effects and Applications
- Forest Insect Ecology and Management
- Nutrition, Health and Food Behavior
- Energy and Environmental Systems
- Dental Research and COVID-19
- Inflammasome and immune disorders
- Endodontics and Root Canal Treatments
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Blood groups and transfusion
- Organizational and Employee Performance
- Immune Cell Function and Interaction
- Colorectal Cancer Screening and Detection
- Antimicrobial Peptides and Activities
- Inflammatory Biomarkers in Disease Prognosis
Pusan National University
2024
Hallym University Medical Center
2022
Seoul National University
2017-2020
Konyang University
2020
Sungkyunkwan University
2018
Wonkwang University
2010
In our previous study, we clearly demonstrated the roles of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6, subsequent reactive oxygen species (ROS) generation on pathogenesis cisplatin ototoxicity in vitro vivo . ROS cisplatin-treated HEI-OC1 auditory cells was also correlated with changing mitochondrial membrane potential. However, NADPH oxidase cisplatin-induced have not been fully elucidated. Herein, immunohistochemical studies that...
Abstract Dysfunction in immune surveillance during anticancer chemotherapy of patients often causes weakness the host defense system and a subsequent increase microbial infections. However, deterioration organ-specific function related to challenges cisplatin-treated has not yet been elucidated. In this study, we investigated cisplatin-induced TLR4 expression its binding LPS mouse cochlear tissues effect interaction on hearing function. Cisplatin increased transcriptional translational...
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process of cellular transdifferentiation by which endothelial cells (ECs) lose their characteristics and acquire mesenchymal properties, leading to cardiovascular remodeling complications in the adult diseases environment. Melatonin involved numerous physiological pathological processes, including aging, has anti-inflammatory antioxidant activities. This molecule an effective therapeutic candidate for preventing oxidative...
Activating transcription factor-3 (ATF3) in the ER stress pathway induces cytokine production and promotes survival during gram-positive bacterial infection. IL-17A is a critical that essential for clearance of Streptococcus pneumoniae. However, mechanism by which ATF3 remains unknown. Here, we show via NLRP3 inflammasome-dependent IL-1β secretion. Survival rates were comparable IL-17A-depleted KO mice but lower than WT treated with isotype control, indicating positively regulated...
Background: GV1001 is a human telomerase peptide vaccine that induces CD4/CD8 T-cell response against cancer cells, thereby affording an immunological anti-tumor effect. Here, we evaluated the efficacy and safety of in combination with chemotherapy patients metastatic colorectal who had failed first-line chemotherapy. Methods: This multicenter, non-randomized, single-arm phase II study recruited recurrent or measurable disease Patients received concomitantly based on pre-established...
Abstract We developed a diet and lifestyle score based on high sensitivity C-reactive protein (hsCRP), investigated its association with odds of adenoma. performed stepwise linear regression to develop the predicted hsCRP among 23,330 participants in Health Examinee Study examined colorectal adenoma 1,711 cross-sectional study estimated ratios (ORs) 95% confidence intervals (CIs) using logistic models. Variances explained by body mass index were 61.1% men 64.5% women prediction model. The...
Prevention of dental caries is a key research area, and improvement the pit fissure sealants used for prevention has been particular interest. This report describes results incorporating zwitterion, sulfobetaine methacrylate (SB), into photo-polymerized resin-based to enhance resistance cariogenic bacteria protein adhesion. Varying amounts (1.5-5 wt%) SB were incorporated sealant, flexural strength, wettability, depth cure, adhesion, bacterial viability, cell cytotoxicity resultant...
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease that often associated with genetic defects.Mutations of complement factor H (CFH) are the most common defects cause aHUS and result in end-stage renal disease.Since CFH mainly produced liver, liver transplantation (LT) has been performed patients defective CFH.Methods: The clinical courses four kidney allograft recipients who lost their native functions due to mutation were reviewed.Results: Subject A underwent (KT)...
Sogunjung-tang (SGJT) is traditional herbal prescriptions used to treat abdominal pain. In this study, we evaluated the effect on inflammation and gastritis through SGJT formulation development. composition medicine was boiled in water at 95~100℃ for 3 hours then concentrated. mix soft extract (STM) prepared using pharmaceutical excipients such as purified water, sodium benzoate, β-cyclodextrin CMC-Na. Anti-inflammatory experiment conducted STM lipopolysaccharide (LPS) RAW 264.7 cells. Cell...
The purpose of this study is to analyze 11-year cumulative survival rate on immediate implants placed between 2006 and 2016 at Seoul National University Dental Hospital by one periodontist (Y. K). With an aggregate 185 were calculated with Life table method assessed the effect predictor variables Kaplan-Meier analysis Cox proportional hazard model. After a mean follow-up time 4.67 years, 16 failed 169 survived among implants. overall rates 5 11 years 90% 90%, respectively. No statistically...