A5018855985- Acute Myeloid Leukemia Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- SARS-CoV-2 and COVID-19 Research
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Kruppel-like factors research
- Immunodeficiency and Autoimmune Disorders
- Multiple and Secondary Primary Cancers
Hallym University Medical Center
2013-2022
Hallym University Sacred Heart Hospital
2009-2022
Hallym University
2009-2022
Incheon Medical Center
2021
Neighborhood Health
2020
Boston Medical Center
2020
Hallym University Kangnam Sacred Heart Hospital
2018
Kosin University
2010-2015
Korea Research Institute of Bioscience and Biotechnology
2015
Sungkyunkwan University
2009-2014
Metastatic colorectal cancer (CRC) patients with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are resistant to treatment cetuximab, a monoclonal antibody that targets the epidermal growth factor receptor. Statins have reported antitumor activity, but it is unknown whether simvastatin can reverse cetuximab resistance in KRAS mutant CRC. Human CRC cell lines (LS153, LS174T, DLD1, LoVo, SW403, SW480, SNU175, and LS1034) or v-raf murine B1 (BRAF) (DiFi, SW48, HT29, RKO)...
Annexin A2 (ANXA2) expression is highly upregulated in many types of cancer. Although cell surface localization ANXA2 has been reported to have a critical role the progression and metastasis variety tumors, including pancreatic cancer, biological intracellular not fully understood. Herein was investigated cancer line. We first determined whether involved NF-κB signaling pathways. bound p50 subunit calcium-independent manner, ANXA2-p50 complex translocated into nucleus. Furthermore, increased...
4001 Background: Adjuvant chemotherapy and/or chemoradiotherapy have been the standard of care in GC for years, supported by randomized trials. We compared efficacy different regimens and patients with D2-resected, stage II/III, node-positive GC. Methods: From Feb 2013 through Nov 2018, we randomly assigned, a 1:1:1 ratio, pathologically-staged II or III, node-positive, D2-resected GC, to receive adjuvant S-1 (40-60 mg twice daily 4-weeks-on/2-weeks-off) one year, (2-weeks-on/1-week-off)...
The impact of pretreatment nutritional status on the treatment outcome non-Hodgkin lymphoma has never been explored. Among 953 patients who were registered in a prospective cohort at Samsung Medical Center., we analyzed 262 had treated with Ruximab-cyclophosphamide, doxorubicin, vincristine, and prednisone for newly diagnosed diffuse large B-cell (DLBCL) whom data available regarding status. Nutritional diagnosis was assessed by triceps skin fold (TSF), mid-arm muscle circumference (MAMC),...
Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor non-small-cell cancer (NSCLC) with conflicting results. We conducted this meta-analysis gain better insight into the role patients only non-squamous (non-SQ) NSCLC. A systematic computerized search electronic databases including PubMed, PMC, EMBASE, Web Science, and Cochrane...
BackgroundPatients with diabetes are known to be at high risk for end-stage kidney disease (ESKD), but the accurate annual data new-onset ESKD is still limited. In South Korea, prevalence and incidence of increasing more rapidly compared global average. This study aimed determine rate (IR) by status from 2012 2022. MethodsUsing Korean National Health Insurance Service, we calculated IR hazard ratio (HR) newonset in general population. Individuals were categorized based on into nondiabetes,...
Diffuse large B-cell lymphoma (DLBCL) constitutes most primary central nervous system (CNS) (PCNSL), whereas T-cell, low-grade and Burkitt's lymphomas (BL) are rarely encountered. Due to the paucity of cases, little is known about clinical features treatment outcomes PCNSL other than DLBCL. The objective this study was describe characteristics for patients with Fifteen patients, newly diagnosed PCNSLs DLBCL between 2000 2010, were included. male female ratio 0.67:1 a median age diagnosis 31...
To examine whether hospital-based physical therapy is associated with functional changes and early hospital readmission among hospitalized older adults community-acquired pneumonia declining function. Study design was a retrospective observation study. Participants were community-dwelling admitted to medicine floor for (n = 1,058). Their function using Katz activities of daily living (ADL) Index declined between admission 48 hours since (Katz ADL 6→5). The intervention group those receiving...
Fibroblast growth factor receptor-2 (FGFR2) protein expression by immunohistochemistry has been reported in up to 60% of patients with gastric cancer (GC). However, the clicopathological impacts high FGFR2 have not consistent among studies. We conducted this meta-analysis evaluate pathological and prognostic significance overexpression GC. A systematic search electronic databases including PubMed, PMC, EMBASE, Google Scholar was performed. From ten studies, 4,294 were included pooled...
Everolimus is a novel inhibitor of the mammalian target rapamycin pathway, which aberrantly activated in cancer cell. We conducted phase I study capecitabine plus everolimus (RAD001) refractory gastric patients.Patients with metastatic and progression after prior chemotherapy were eligible. Four dose levels planned as follows: Level 1, 5 mg bid/day (D1-D21) 500 mg/m(2) (D1-14); 2, 750 3, 1000 4, 10 (D1-14). Treatment was repeated every 3 weeks until disease progression, patient refusal, or...
For patients with refractory bone and soft tissue sarcoma (STS), treatment options have been limited. Ifosfamide is an alkylating agent well-demonstrated efficacy against STS, dose-dependent activity. The aim of this retrospective study was to evaluate the response rate, progression-free survival (PFS), rate (PFR), median duration high-dose ifosfamide (HDI) as at least second-line chemotherapy for advanced STS.Thirty metastatic, unresectable who were treated HDI between May 1999 November...
Although gemcitabine plus cisplatin has been established as the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC), overall prognosis remains poor. We investigated efficacy of a novel triplet combination oxaliplatin, irinotecan, and S-1 (OIS) BTC.Chemotherapy-naive patientswith histologically documented unresectable or metastatic BTC were eligible this multicenter, single-arm phase II study. Patients received 65 mg/m2 oxaliplatin (day 1), 135 irinotecan 40...
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a rare complex of structural abnormalities the female urogenital tract. A 17-year-old girl with uterine didelphys associated OHVIRA presented progressive development cyclic lower abdominal discomfort large abdominopelvic mass. We describe findings from ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), first case report this to examine all three different modalities in single patient. also review...
Background: GV1001 is a human telomerase peptide vaccine that induces CD4/CD8 T-cell response against cancer cells, thereby affording an immunological anti-tumor effect. Here, we evaluated the efficacy and safety of in combination with chemotherapy patients metastatic colorectal who had failed first-line chemotherapy. Methods: This multicenter, non-randomized, single-arm phase II study recruited recurrent or measurable disease Patients received concomitantly based on pre-established...
Aberrations in the fibroblast growth factor receptor2 (FGFR2) gene, including genetic alterations and chromosomal rearrangements, lead to development progression of cancer with poor prognosis. However, mechanisms underlying FGFR2 signaling pathway facilitate FGFR2-targeted therapies have not been fully explored. Here, we examined clinicopathological features amplification fusion gastrointestinal tract/genitourinary tract cancers. were identified approximately 1.5% 1.1% all types 1,373...
Low prevalence and prognostic relevance of KRAS mutations in Korean pancreatic ductal adenocarcinomas (PDACs) need to be validated with sensitive detection method.Peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping was used precisely detect mutation 72 paraffinized tumor samples by cell lines compare the efficiency direct sequencing.The PNA-mediated PCR detected mutant allele proportions as low 0.5% against a background wild-type DNA 20-fold more than sequencing...
This study aimed to examine whether muscle force and tendon stiffness in a muscle-tendon complex alter synchronously following 8-week whole-body vibration (WBV) training older people. Forty women aged 65 years were randomly assigned into control (CON, n = 15) groups (exposure time, 13; intensity, 12). For the groups, 4-week detraining period was completed period. Throughout training/detraining period, of medial gastrocnemius (MG) Achilles assessed four times (0, 4, 8, 12 weeks) using...