Endoscopic submucosal dissection (ESD) is a well-established method for the treatment of gastrointestinal epithelial tumors. However, gastric subepithelial tumors (SETs) that originate from muscularis propria layer still depends primarily on surgical techniques. We evaluated appropriate indications ESD in SETs layer.Thirty-five patients with who underwent were enrolled, and charts retrospectively reviewed to investigate parameters predictive complete resection complications.The mean age was...

DNA deacetylation by histone deacetylase (HDAC) is an important mechanism involved in the oncogenic tumorigenesis of breast cancer. Previous studies have reported association estrogen receptor (ER) with HDACs and demonstrated efficacy HDAC inhibitors for treatment cancers via vitro experiments. In this study, we examined expression clinicopathological parameters disease-specific survival. Immunohistochemical (IHC) analysis HDAC1, HDAC2, HDAC3, HDAC6 was performed using tissue microarrays 300...

MET, a cell surface receptor for hepatocyte growth factor, is involved in the development of triple-negative/basal-like breast cancer (TNBC/BLBC). However, its utility as therapeutic target this subtype poorly understood. To evaluate MET fully potential TNBC/BLBC, we investigated relationship between expression and clinical outcomes patients with functional effect inhibition. Using automated immunohistochemistry (Ventana), analyzed 924 relevant clinicopathologic parameters. BLBC showed...

<h3>Importance</h3> A connection between Meniere disease (MD) and migraine has been proposed, but the temporal association remains unknown. <h3>Objective</h3> To examine bidirectional of MD with migraine. <h3>Design, Setting, Participants</h3> This case-control study included participants 40 years or older from Korean National Health Insurance Service Screening Cohort 2002 to 2015. <h3>Main Outcomes Measures</h3> total 6919 patients were matched 27 676 control without for age, sex, income,...

Thyroid dysfunction is linked to an increased risk of cognitive impairment. However, studies on the relationships between thyroid diseases and Alzheimer's disease (AD) have reported conflicting results. We investigated associations several AD in a nested case-control study.

Background: Public health concerns regarding the potential link between osteoporosis and increased occurrence of Alzheimer's disease (AD) Parkinson's (PD) have been raised, but results remain inconsistent require further validation. Here, we investigated long-term relationship with AD/PD using data from a large-scale nationwide cohort. Methods: This longitudinal follow-up study included 78,994 patients controls Korean National Health Insurance Service-Health Screening Cohort database...

Esophageal cancer constitutes a global public health challenge. However, South Korean population-specific information on the association of lifestyle (smoking, alcohol consumption, and obesity status) with esophageal risk is sparse. This nested case–control study analyzed national screening cohort data (2002–2019) 1114 patients 4456 controls (1:4 propensity-score matched for sex, age, income, residential region). Conditional unconditional logistic regression analyses, after adjustment...

Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson’s disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing nested case-control design, study explored subsequent occurrences in Korean adults, leveraging validated national population-based dataset covering period from 2002 to 2019. It included 8794 patients 35,176 matched control individuals,...

Background: Radiomics is a non-invasive and cost-effective method for predicting the biological characteristics of tumors. In this study, we explored association between radiomic features derived from magnetic resonance imaging (MRI) genetic alterations in patients with breast cancer. Methods: We reviewed electronic medical records cancer available targeted next-generation sequencing data August 2018 May 2021. Substraction T1-weighted sequences was utilized. The tumor area on MRI segmented...

Objective: The association between periodontitis and benign prostatic hyperplasia (BPH) has been controversial. This study aimed to estimate the recurrent episodes occurrence of BPH in an adult male population Korea. Methods: analyzed data from 79,497 matched cases controls examine relationship BPH, using Korean National Health Insurance Service-Health Screening Cohort data. Conditional logistic regression was used calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting...

Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders, but their potential association with lung cancer risk and mortality remains underexplored debated. This study sought to investigate the between PPI use likelihood mortality, focusing on impact of exposure history duration. utilized data from 6795 patients, 27,180 matched controls, 4257 deceased 2538 surviving patients Korean National Health Insurance Service's Screening Cohort (2002-2019). Propensity...

Rapid, accurate preoperative imaging diagnostics of appendicitis are critical in surgical decisions emergency care. This study developed a fully automated diagnostic framework using 3D convolutional neural network (CNN) to identify and clinical information from patients with abdominal pain, including contrast-enhanced abdominopelvic computed tomography images. A deep learning model-Information Appendix (IA)-was developed, the volume interest (VOI) region corresponding anatomical location...

Chronic periodontitis (CP) has been linked to an increased risk of sudden sensorineural hearing loss (SSNHL). This study aimed delineate the causal relationships between CP and SSNHL. Data from 40-year-old participants in Korean National Health Insurance Service-Health Screening Cohort 2002 through 2019 were used. The data 13,769 patients with SSNHL collected matched those 55,076 control terms demographic socioeconomic variables. incidence before onset was recorded. odds ratios (ORs) for...

Background: Previous reports suggest a connection between gout and asthma; however, additional research is required to clarify this link. This study explores the relationship asthma using data from Korean National Health Insurance Service-Health Screening Cohort. Methods: Participants were selected according medical claim codes, individuals diagnosed with paired control subjects at 1:4 ratio. Variables, including demographic characteristics, health-related information, history, incorporated...

IDH mutation and MGMT promoter methylation are reliable prognostic predictive biomarkers in grade II-IV diffuse gliomas. Recurrent mutations the region of telomerase reverse transcriptase (TERTp) gene have also been found However, effects TERTp on or status largely unknown. IDH1/2 mutations, as well statuses, were examined via peptide nucleic acid-mediated PCR clamping methylation-specific 67 paraffinized tumor samples, respectively. was associated with older patients (≥60 years) frontally...

Postoperative neutrophil-to-lymphocyte ratio change (NLRc) reflects the dynamic of balance between host inflammatory response and immune after treatment. In gastric cancer, an elevated initial NLR (iNLR) is reported to be a prognostic predictor, but clinical application NLRc remains unclear. The was assessed in 734 patients undergoing total/subtotal gastrectomy endoscopic submucosal dissection for adenocarcinoma. iNLR were recorded within 10 days first diagnosis 3-6 months surgery,...

High expression of glucose transporter family members, which augment uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation survival tumor cells, contributing energy supply, biosynthesis homeostasis cancer cells. Among many solute carrier 2 member 1 (SLC2A1) encodes transporter, GLUT1, that is critical metabolism glucose, an source for cell growth contributes progression development. The aim this study was analyze genetic changes/immune profiles patients with...

Abstract Cancer-associated fibroblasts (CAFs) participate in critical processes the tumor microenvironment, such as extracellular matrix remodeling, reciprocal signaling interactions with cancer cells and crosstalk infiltrating inflammatory cells. However, relationships between CAFs survival are not well known lung cancer. The aim of this study was to reveal correlations rates, genetic alterations immune activities. This reviewed histological features 517 patients adenocarcinoma from Cancer...

Abstract Background Safety concerns against the use of proton pump inhibitors (PPIs) based on risk dementia, especially Alzheimer’s disease (AD), remain controversial. Here, we investigated likelihood AD depending previous PPI exposure, duration, and generation. Methods This nested case–control study comprised 17,225 patients who were 1:4 matched with 68,900 controls for age, sex, income, region residence from Korean National Health Insurance Service-Health Screening Cohort data between 2002...

Acute nephrotoxicities of melamine (MEL), cyanuric acid (CA), and a mixture both (MC) were comparatively investigated in male Sprague-Dawley rats at 5 doses each with 10-fold dose interval as follows: MEL 0.0315, 0.315, 3.15, 31.5, 315 mg/kg; CA 0.025, 0.25, 2.5, 25, 250 mg/kg, MC: [1×: (0.0315 + 0.025), 10×: (0.315 0.25), 100×: (3.15 2.5), 1000×: (31.5 25), (315 250) mg/kg]. No marked adverse effects renal function observed animals treated alone or alone, but evidence related to...

Background Matrix metalloproteinase-9 (MMP-9) is associated with remodelling of the extracellular matrix and invasion in various cancers. Identifying proteins connected to high MMP-9 expression important explaining its mechanisms. Our study aims shed light on genes discuss their clinical impact breast cancer. Methods We evaluated 173 cancer cases from Kangbuk Samsung Hospital, 1964 Molecular Taxonomy Breast Cancer International Consortium database serving as a validation cohort. investigated...

Rectal neuroendocrine tumors (NETs) are the most common gastrointestinal (GI) NETs with an uncertain malignant potential despite their small size. There limited data about driver mutations in rectal NETs, which may explain tumors' unexpected behavior or histologic morphology other GI-NETs. Here, we investigated clinically and pathologically relevant of nonrectal compared frequency clinical significance detected between them. We sequenced 84 primary GI-NETs (69 rectal, 7 gastric, 5...