A5100611463- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Minimally Invasive Surgical Techniques
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Thyroid and Parathyroid Surgery
- Breast Lesions and Carcinomas
- Biosimilars and Bioanalytical Methods
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Surgical Sutures and Adhesives
- Venous Thromboembolism Diagnosis and Management
- Adrenal and Paraganglionic Tumors
- Mast cells and histamine
- Transgenic Plants and Applications
- Advanced Breast Cancer Therapies
- Botulinum Toxin and Related Neurological Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Genetically Modified Organisms Research
Hallym University Sacred Heart Hospital
2018-2025
Deleted Institution
2023
Hallym University
2019
Mount Sinai Medical Center
2011
Background: Radiomics is a non-invasive and cost-effective method for predicting the biological characteristics of tumors. In this study, we explored association between radiomic features derived from magnetic resonance imaging (MRI) genetic alterations in patients with breast cancer. Methods: We reviewed electronic medical records cancer available targeted next-generation sequencing data August 2018 May 2021. Substraction T1-weighted sequences was utilized. The tumor area on MRI segmented...
Background: The prognostic relevance of the PIK3CA mutation together with PD-L1, c-Met, and mismatch repair deficiency (dMMR) have not been fully investigated in Asian women breast cancer (BC) who undergone postoperative adjuvant chemotherapy. Methods: We analyzed mutations via peptide nucleic acid (PNA)-mediated real-time PCR assay, PD-L1/c-Met expression immunohistochemistry (IHC), microsatellite instability (MSI) status using IHC, 191 resected BCs from 2008 to 2011. Cancer Genome Atlas...
The relationship between cancer and venous thromboembolism (VTE) has long been described. risk of VTE in Asian patients with breast remains largely unknown. This study described the incidence factors Korean cancer. Data were collected from a retrospective database who underwent surgery 2011 2020 at single institution. Cox proportional-hazards model was used to identify associated occurrences. Among 2246 cancer, 48 (2.1%) developed during median follow-up period 53 months. average 459 per...
Few studies have reported on the clinical utility of targeted next-generation sequencing (NGS) for breast cancer in Korea. We retrospectively reviewed NGS data 219 patients with who underwent surgical resection between August 2018 and April 2021. Here, we described mutational profiles examined their prognostic implications. The most frequently mutated gene was PIK3CA (n = 97/219, 44.3%), followed by TP53 79/219, 36.1%), AKT1 23/219, 10.5%), GATA3 20/219, 9.1%). mutations were associated...
During transoral endoscopic thyroidectomy vestibular approach (TOETVA), the mental nerve can be injured by lateral ports. Mental injury is a worrisome complication, which minimized using single-port platform. A 56-year-old woman was diagnosed with 5-mm sized papillary thyroid carcinoma on isthmus. horizontal 21-mm incision made mucosa at lower lip, followed vertical dissection from mentalis muscles down to mandibular area. Subsequent hydrodissection widened working space. For procedure,...
Prediction of malignant behavior pheochromocytoma (PC) or paraganglioma (PG) is limited value. The Cancer Genome Atlas (TCGA) and the French ‘Cortico et Médullosurrénale: les Tumeurs Endocrines’ (COMETE) network in Paris (France) facilitate accurate differentiation PC/PG based on genetic information. Therefore, objective this transcriptome analysis to identify prognostic genes underlying TCGA COMETE databases. carries data pertaining multigenomic 173 surgical resection samples while cohort...
Background: Breast cancer is the most common among women. The Korean Genome and Epidemiology Study (KoGES) a large cohort study that available to public. Using this study, we aimed unravel relationship between breast development family history of in Korea. Methods: This relied on data from KoGES 2001 through 2013. A total 211,725 participants were screened. Of these, 129,374 women evaluated. They divided into two groups, including with without cancer. logistic regression model was used...
Total gastrectomy with Roux-en-Y esophagojejunostomy is a common surgical treatment for early gastric cancer; however, postoperative complications such as anastomotic leaks remain serious risk. This report details 59-year-old female who underwent total cancer, followed by percutaneous embolization esophagojejunal (EJ) leakage. Despite initial drainage fluid accumulation at the EJ site, subsequent CT revealed significant dehiscence. Endoscopic was ineffective and intervention posed high risk...
The trastuzumab biosimilar CT-P6 is approved for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer (EBC), metastatic (MBC), and gastric (MGC). objective of this post-marketing surveillance (PMS) study was to evaluate the real-world safety effectiveness in patients with HER2-positive cancers.
Abstract Background With the positive outcomes associated with Ovarian Function Suppression (OFS) treatment as reported in ASTRRA study, which compare two therapeutic strategies, tamoxifen alone and ovarian function suppression premenopausal patients after chemotherapy, role of OFS has getting important. However, considering increased risk bone density reduction postmenopause women, understanding these effects is crucial devising strategies that not only effectively combat cancer but also...
There is limited evidence regarding the impact of coronavirus disease 2019 (COVID-19) pandemic on epidemiology thoracic and cardiovascular diseases. This study aimed to investigate changes in medical visits for these conditions during COVID-19 pandemic.
This study aimed to compare the complication rates of non-absorbable suture (NAS) and n-butyl-2-cyanoacrylate (NBCA) skin adhesive for closure during totally implantable venous access devices (TIVADs) implantation.Between March 2020 February 2021, 586 consecutive patients who underwent TIVAD implantation were retrospectively analyzed. Two groups with NAS (n = 299) or NBCA 287) followed up 18 months occurrence infection, thrombosis, non-thrombotic malfunction. A total 364 cases extracted...
The aim of our study was to present an abdominal wall closure technique using barbed suture V-Loc™ 90 after single incision laparoscopic appendectomy (SILA) and compare perioperative outcomes with conventional layer by SILA.
Purpose Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC cancer. Methods From a multicenter database, retrospectively enrolled 611 (355 men 256 women) who had undergone potentially curative resection for adenocarcinoma between 2003 2011. The primary end-point was 5-year DFS. Results median age 62 years; 213 398...
Other SectionsAbstractINTRODUCTIONMATERIALS AND METHODSRESULTSDISCUSSIONCONCLUSIONCONFLICT OF INTERESTFUNDINGACKNOWLEDGMENTSReferences
Adipose-derived stem cells (ADSCs) are potential therapeutics considering their self-renewal capacity and ability to differentiate into all somatic cell types in vitro. The ideal ADSC-based therapy is a direct injection the relevant organs. objective of this study was investigate viability safety intra-organ human ADSC (h-ADSC) xenotransplants vivo. Subcutaneous adipose tissue from abdominal area 10 patients sampled. h-ADSCs were isolated samples identified using immunofluorescence...
e13025 Background: CT-P6 is a biosimilar trastuzumab product approved in many countries worldwide, including the European Union and United States. This study aims to confirm safety effectiveness of routine clinical practice settings for indications HER2-positive metastatic breast cancer (MBC), early (EBC), gastric (MGC) Republic Korea. Methods: The observational, prospective, multi-center, post-marketing surveillance (PMS) was conducted from October 5, 2018 4, 2022, on Korean patients...
Abstract Targeting appropriate driver genes is crucial in cancer precision medicine. To find oncogenic drivers, targeted next-generation sequencing becoming widely used the clinical field. Using sequencing, we aimed to detect targetable genetic alterations and characterize mutational profiles of breast cancer. We analyzed biopsy specimens using customized 50-gene panel. In total, 196 patients primary operable were selected from single institution South Korea. Among patients, 22 kinds...
Purpose: Breast and thyroid cancers are the two most commonly diagnosed in women.Many studies have described an increased risk of cancer breast patients.This may be related to hormonal exposure, genetic susceptibility, detection bias, treatment.We thus performed a retrospective descriptive study which aimed assess incidence prevalence patients.Methods: We reviewed electronic medical records patients who had undergone surgery between January 2013 December 2017 single tertiary...