A5101821991- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Cancer and Skin Lesions
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Breast Implant and Reconstruction
- Diverse Approaches in Healthcare and Education Studies
- Pelvic floor disorders treatments
- Medical Imaging Techniques and Applications
- Neutropenia and Cancer Infections
- Pancreatic and Hepatic Oncology Research
- Urological Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- Advanced Breast Cancer Therapies
Soonchunhyang University
2016-2025
Pusan National University
2023
Soonchunhyang University Hospital
1999-2022
Hanyang University
2021-2022
Hanyang University Seoul Hospital
2021
Kangbuk Samsung Hospital
2021
Samsung Medical Center
2021
Chonnam National University Hospital
2021
Pusan National University Hospital
2021
Catholic University of Korea
2003-2021
PURPOSE The addition of ovarian function suppression (OFS) for 5 years to tamoxifen (TAM) treatment premenopausal patients with breast cancer after completion chemotherapy has beneficial effects on disease-free survival (DFS). This study evaluated the efficacy adding 2 OFS TAM in hormone receptor–positive who remain a state or resume chemotherapy. PATIENTS AND METHODS We enrolled 1,483 women (age ≤ 45 years) estrogen treated definitive surgery completing adjuvant neoadjuvant Ovarian was...
To determine the updated long-term outcomes of Addition Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial.This study is a post-trial follow-up ASTRRA trial, involving 1,483 premenopausal women younger than 45 years treated with definitive surgery after completing adjuvant neoadjuvant chemotherapy for estrogen receptor-positive breast cancer. Patients were randomly assigned...
The interaction of programmed death receptor 1 (PD-1) and its ligand, ligand (PD-L1), negatively regulates immune responses. This study aimed to clarify PD-L1 expression levels in breast cancer through immunohistochemistry (IHC) evaluate associations between these findings clinicopathologic variables, including prognosis. was analyzed using IHC on tissue microarrays 465 invasive carcinomas. High demonstrated 63 tumors (13.5%). significantly associated with high histologic grade (p<0.001),...
Breast cancer is the second most common malignancy among Korean women. The 2002 National Cancer Center screening guideline breast was revised via an evidence-based approach to provide medical personnel with a standard protocol of cancer. There moderate-level evidence that biennial mammography in asymptomatic women aged 40 69 reduces mortality, while low-level suggests 70 years or older does not reduce mortality. committee concluded current insufficient assess benefits and harms either...
TAC chemotherapy is a standard adjuvant treatment for early-stage breast cancer, with G-CSF recommended preventing febrile neutropenia (FN). This study investigates the optimal initiation timing daily filgrastim to prevent FN in patients undergoing chemotherapy, subject not fully explored existing guidelines. Sixty cancer receiving were randomly assigned start either on Day 2 (Day group, n = 30) or 5 30). The primary outcome was incidence of FN. Secondary outcomes included duration and...
Prevalence and phenotype of BRCA mutation can vary by race. The purpose this study is to evaluate the prevalence BRCA1/2 mutations in non-familial breast cancer patients with high risks Korea. A subset 758 was selected for from KOHBRA nationwide multicenter prospective cohort study. Mutations genes were tested using fluorescent-conformation sensitive gel electrophoresis, denaturing performance liquid chromatography or direct sequencing. Mutation identified 65 (8.6%) among total [BRCA1...
Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose this study was to evaluate nuclear expression ARID1A cancers by immunohistochemistry (IHC) and correlate findings clinicopathologic variables prognostic significance. IHC performed on tissue microarrays 476 cases Associations between characteristics molecular subtype were retrospectively analyzed. Low found 339...
The enhancer of zeste homologue 2 (EZH2) is a catalytic subunit the polycomb repressive complex 2, highly conserved histone methyltransferase. EZH2 overexpression has been implicated in various malignancies, including breast cancer, where associated with poor outcomes. This study aims to clarify nuclear expression levels cancers using immunohistochemistry (IHC) and correlate these findings clinicopathologic variables, prognostic significance. IHC was performed on tissue microarrays 432...
Abstract Background The objective of this study was to investigate the prognostic value 2-Deoxy-2-[ 18 F]fluoro-D-glucose ([ F]FDG) uptake bone marrow (BM) and metabolic parameters primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer. Methods Pretreatment [ F]FDG PET/CT images 345 cancer were retrospectively evaluated. Maximum standardized value, volume, total lesion glycolysis (TLG) marrow-to-liver ratio...
Purpose:The aim of the present study aimed to evaluate effect testosterone on cardiovascular disease by using Framingham Risk Score (FRS) in patients with sexual dysfunction. Materials and Methods:A total 308 men dysfunction were enrolled this study.Clinical assessments included 15-item International Index Erectile Function (IIEF), blood pressure measurement, clinical laboratory indexes.The FRS, which predicts incidence rate diseases next 10 years, was calculated basis age, gender,...
Ovarian function suppression (OFS) has been shown to be effective as adjuvant endocrine therapy in premenopausal women with hormone receptor-positive breast cancer. However, it is currently unclear if addition of OFS standard tamoxifen after completion chemotherapy results a survival benefit. In 2008, the Korean Breast Cancer Society Study Group initiated ASTRRA randomized phase III trial evaluate efficacy treatment cancer patients who remain or regain status chemotherapy. Premenopausal...
506 Background: Addition of Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial, at 63 months median follow-up, showed that the addition 2 years ovarian function suppression (OFS) (TAM) significantly improved disease-free survival (DFS) compared with TAM alone patients hormone receptor–positive breast cancer who remain a premenopausal state resume after chemotherapy. We...
To compare the outcomes between laparoscopic total extraperitoneal (TEP) repair and prolene hernia system (PHS) for inguinal hernia.A retrospective analysis of 237 patients scheduled TEP or PHS groin from 2005 to 2009 was performed.The mean age 52.3 years in group 55.7 group. Of 119 cases, 98 were indirect hernia, 15 direct type, 5 femoral 1 complex hernia; 118 100 indirect, 18 type. All performed under general anesthesia 64% spinal epidural anesthesia. Preoperatively, 10 cases recurrent...
502 Background: The role of adding ovarian function suppression (OFS) to tamoxifen (T) for premenopausal patients with breast cancer after completing (neo) adjuvant chemotherapy is uncertain. prospective randomized phase III trial was conducted evaluate the efficacy OFS T in hormone receptor-positive who remain status or resume (NCT00912548). primary and key secondary endpoints were compare 5-year disease-free survival overall survival, respectively, between received those OFS. Methods: We...
The purpose of this study was to evaluate the prognostic significance computed tomography (CT)-attenuation tumor-adjacent breast adipose tissue for predicting recurrence-free survival (RFS) in patients with cancer. We retrospectively enrolled 287 cancer who underwent pretreatment 18F-fluorodeoxyglucose (FDG) positron emission (PET)/CT. From non-contrast-enhanced CT images PET/CT, CT-attenuation values (TAT HU) and contralateral (CAT were measured. Difference (HU difference) percent...
We investigated whether textural parameters of peritumoral breast adipose tissue (AT) based on F-18 fluorodeoxyglucose (FDG) PET/CT could predict axillary lymph node metastasis in patients with cancer. A total 326 cancer preoperative FDG were retrospectively enrolled. images visually assessed and the maximum uptake nodes (LN SUVmax) was measured. From AT, 38 features PET imaging extracted. The diagnostic ability visual analysis, LN SUVmax, AT for predicting using area under receiver...