A5062491053- Pelvic floor disorders treatments
- Breast Cancer Treatment Studies
- Anorectal Disease Treatments and Outcomes
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Hernia repair and management
- biodegradable polymer synthesis and properties
- Conducting polymers and applications
- Polymer crystallization and properties
- Nutritional Studies and Diet
- 3D Printing in Biomedical Research
- Cervical Cancer and HPV Research
- Dielectric materials and actuators
- Gastrointestinal motility and disorders
- Advanced Welding Techniques Analysis
- Extracellular vesicles in disease
- Advanced Sensor and Energy Harvesting Materials
- Welding Techniques and Residual Stresses
- Periodontal Regeneration and Treatments
- Menstrual Health and Disorders
Konkuk University Medical Center
2009-2025
Chosun University
2003-2023
Konkuk University
2010-2021
Korea Research Institute of Bioscience and Biotechnology
2018
Hanyang University
2014
The University of Texas at Austin
2011
To clarify the effect of anaesthetic agents on cancer immunity, we evaluated effects propofol and sevoflurane natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts apoptosis rate in breast immune cells co-cultures from patients who underwent surgery. Venous blood samples were collected after inducing anaesthesia at 1 24 h postoperatively had undergone The allocated randomly to propofol- or sevoflurane-based groups. We counted detected NK cell CTL with by co-culture a line both also...
Epithelial-mesenchymal transition (EMT) occurs in the tumor microenvironment and presents an important mechanism of cell intravasation, stemness acquisition, metastasis. During metastasis, cells enter circulation to gain access distant tissues, but how this fluid influences cancer biology is poorly understood. Here, we present both vivo vitro evidence that EMT-like also circulating (CTCs) as a result hydrodynamic shear stress (+SS), which promotes conversion...
Bone tissue engineering scaffolds offer the merits of minimal invasion as well localized and controlled biomolecule release to targeted sites. In this study, we prepared injectable hydrogel systems based on visible light-cured glycol chitosan (GC) hydrogels containing bone morphogenetic protein-2 (BMP-2) and/or transforming growth factor-beta1 (TGF-β1) for formation in vitro vivo. The were characterized by storage modulus, scanning electron microscopy (SEM) swelling ratio analyses. developed...
This study aimed to develop a machine learning-based prediction model for predicting multi-gene assay (MGA) risk categories. Patients with estrogen receptor-positive (ER+)/HER2− breast cancer who had undergone Oncotype DX (ODX) or MammaPrint (MMP) were used the model. The development cohort consisted of total 2565 patients including 2039 tested ODX and 526 MMP. MMP utilized single XGBoost model, combined LightGBM, CatBoost, models through soft voting. Additionally, ensemble (MMP + ODX)...
Isoflavones are estrogen-like compounds found in plants and their health effects remain equivocal. We investigated dietary isoflavone intake its associated factors Korean breast cancer survivors, with a comparison to cancer-free women. The usual of survivors (n = 981, mean age 52 yrs) 9 hospitals between 2012 2019 was assessed using 3-day food records or frequency questionnaires (FFQs). They were age-matched 2,943 women who completed FFQs as part nationwide study conducted 2016. used the...
Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel doxorubicin⋅hydrochloride (DOX⋅HCl), called GC10/DOX, in vivo. Visible light irradiation increased storage modulus swelling ratio GC10/DOX precursor. The release DOX⋅HCl from...
The purpose of this study was to determine the benefits and limitations screening for breast cancer using mammography.Descriptive design with follow-up used in study. Data from health insurance claim data were used. population consisted all participants 2009 2014. Crude detection rate, positive predictive value sensitivity specificity and, incidence rate interval calculated.The crude per 100,000 increased 126.3 182.1 positives 741.2 1,367.9 negatives 51.7 76.3 sensitivities 74.6% 75.1% 2014...
Abstract The morphology, tensile, impact properties, and thermal expansion behavior of polycarbonate (PC)/acrylonitrile‐styrene‐butadiene (ABS)/talc composites with different compositions mixing sequences were investigated. From the studies morphology PC/ABS/talc composites, it was observed that some talc particles located in both PC ABS phases blend but most at interface between for every sequence. Aspect ratios determined by TEM image analysis reasonably matched values computed from...
We examined the effects of Rhizoma Dioscoreae Tokoronis extracts (RDTEs) on plasma lipids, body weight, and lipogenic enzymes. Mice were administered a standard chow diet, 60% high-fat or diet with RDTE. that fed containing RDTE found to have lower increases in epididymal adipose tissue weights lessened occurrence hepatic steatosis than mice diet. The decreased adiposity was induced by accounted for levels tumor necrosis factor-α, leptin, glucose higher level adiponectin. administration also...
Ovarian function suppression (OFS) has been shown to be effective as adjuvant endocrine therapy in premenopausal women with hormone receptor-positive breast cancer. However, it is currently unclear if addition of OFS standard tamoxifen after completion chemotherapy results a survival benefit. In 2008, the Korean Breast Cancer Society Study Group initiated ASTRRA randomized phase III trial evaluate efficacy treatment cancer patients who remain or regain status chemotherapy. Premenopausal...
Direct tissue imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization and time-of-flight (MALDI-TOF) has become increasingly important in biology medicine, because this technology can detect the relative abundance spatial distribution of interesting proteins tissues. Five thyroid cancer samples, along with normal tissue, were sliced transferred onto conductive glass slides. After scanning MALDI-TOF equipped a smart beam laser, images created for individual masses...
Poly(butylenes adipate) ionomers (PBAi) were synthesized using dimethyl 5-sulfoisophthalate sodium salt (DMSI) up to 5 mol% of diacid monomer. We have investigated electrical and dielectric properties the evaluate alternating current (AC) parameters such as impedance, conductance, constant, admittance, susceptance, loss, resistance by an impedance spectroscopy. It is seen that ionic conductances increase with increasing content DMSI. The AC conductance for was found vary ωs index s ≥ 1. A...
Distribution of A118G single nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) differs with ethnicity. We assessed distribution this SNP Korean women breast cancer and compared it that other ethnicities cancer. genotypes was as follows: 49.8% for AG genotype, 40.6% AA 9.6% GG genotype. Logistic regression analysis showed a negative association between presence G allele at position 118 OPRM1 studied population (odds ratios [OR], 0.635; p=0.002). However, were not...
The aim of this study was to examine the validity and reproducibility a food frequency questionnaire (FFQ) developed in Korea for breast cancer survivors.Ninety-nine survivors who completed an FFQ twice three 3-day dietary records (DRs) between 2016-2017 were included. Energy 14 nutrient intakes calculated from FFQs DRs. To determine FFQ, energy-adjusted de-attenuated Pearson correlations two assessments average DRs calculated, reproducibility, degrees agreement first second...
Abstract Photothermal therapy (PTT) is a targeted and non‐invasive therapeutic strategy for effective cancer treatment. Image‐guided PTT based on bifunctional near‐infrared (NIR) fluorophores has received significant attention recently the development of NIR advised imaging precise therapy. In this study, multivalent sorbitol‐conjugated fluorophore (4Sorbitol‐800) used as photothermal agent in vivo because high tumor‐targetability sorbitol moieties excellent properties heptamethine cyanine...