A5026740377- Capital Investment and Risk Analysis
- Climate Change Policy and Economics
- Pluripotent Stem Cells Research
- Nanoparticles: synthesis and applications
- Water resources management and optimization
- Mesenchymal stem cell research
- Graphene and Nanomaterials Applications
- Histone Deacetylase Inhibitors Research
- Tissue Engineering and Regenerative Medicine
- Global Energy and Sustainability Research
- 3D Printing in Biomedical Research
- Genomics, phytochemicals, and oxidative stress
- Infrastructure Maintenance and Monitoring
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Phytochemicals and Antioxidant Activities
- Concrete Corrosion and Durability
- Renal and related cancers
- Pancreatic function and diabetes
- Fullerene Chemistry and Applications
- Curcumin's Biomedical Applications
- Caveolin-1 and cellular processes
- Sustainable Building Design and Assessment
- Signaling Pathways in Disease
- Retinoids in leukemia and cellular processes
Konkuk University
2014-2022
Wonkwang University
2018-2022
Yonsei University
2016-2018
Jusung Engineering (South Korea)
2012
Epithelial-mesenchymal transition (EMT) occurs in the tumor microenvironment and presents an important mechanism of cell intravasation, stemness acquisition, metastasis. During metastasis, cells enter circulation to gain access distant tissues, but how this fluid influences cancer biology is poorly understood. Here, we present both vivo vitro evidence that EMT-like also circulating (CTCs) as a result hydrodynamic shear stress (+SS), which promotes conversion...
Abstract Nano‐scale materials are noted for unique properties, distinct from those of their bulk material equivalents. In this study, we prepared spherical silver nanoparticles (AgNPs) with an average size about 30 nm and tested potency to induce neuronal differentiation SH‐SY5Y cells. Human neuroblastoma cells considered ideal in vitro model studying neurogenesis, as they can be maintained undifferentiated state or induced differentiate into neuron‐like phenotypes by several...
This paper identifies 31 critical success factors (CSFs) and suggests a framework for effective stakeholder management in long-term complex megaconstruction (LCM) projects that require more than 10 years multipurpose development. The results of survey on the prioritization these CSFs reveal LCM involve stakeholders do general construction correspondingly wider range changes during each project. To identify systematic strategic approaches to projects, was developed through factor analysis...
Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 overexpressed may play crucial role in tumorigenic transformation. our previous study, we revealed the of as signaling component mediated Wnt/NOTCH crosstalk through NUMB transcription breast cancer. Here, investigated function cancer reprogramming drug resistance cells. We found that expression was attenuated patients-derived...
An understanding of the impacts climate change on infrastructure is important in context reducing future socioeconomic losses. Previous research has introduced models based empirical and mechanical analyses to predict behavior considering change. However, uncertainty unavailability information regarding prevent widespread use these previous models. This paper presents a method for developing impact-assessment system using fuzzy inferences alteration service life. Fuzzy enable an...
Valproic acid (VPA), a well-known histone deacetylase (HDAC) inhibitor, is used as an anti-cancer drug for various cancers, but the synergistic effect of VPA and doxorubicin (DOX) combination treatment its potential underlying mechanism in hepatocellular carcinoma (HCC) remain to be elucidated. Here, we evaluate mono- combination-therapy effects DOX HCC identify specific efficient, anti-proliferative cells, especially HepG2 cells; this was not apparent MIHA normal hepatocyte cell line. The...
Mesenchymal stromal cells (MSCs) release extracellular vesicles (MSC-EVs) containing various cargoes. Although MSC-EVs show significant therapeutic effects, the low production of EVs in MSCs hinders MSC-EV-mediated development. Here, we developed an advanced three-dimensional (a3D) dynamic culture technique with exogenous transforming growth factor beta-3 (TGF-β3) treatment (T-a3D) to produce potent MSC-EVs. Our system enabled preparation a highly concentrated EV-containing medium for...
The availability of autologous adult stem cells is one the essential prerequisites for human cell therapy. Urine-derived (USCs) are considered as desirable sources therapy because donor-specific USCs easily and non-invasively obtained from urine. Efficient isolation, expansion, differentiation methods necessary to increase their availability. Here, we developed a method efficient isolation expansion using Matrigel, rho-associated protein kinase (ROCK) inhibitor, Y-27632. prepared showed...
Abstract Nano‐scale materials are noted for unique properties, distinct from those of their bulk material equivalents. In this study, we prepared spherical silver nanoparticles (AgNPs) with an average size about 30 nm and tested potency to induce neuronal differentiation SH‐SY5Y cells. Human neuroblastoma cells considered ideal in vitro model studying neurogenesis, as they can be maintained undifferentiated state or induced differentiate into neuron‐like phenotypes by several...
Breakthroughs in stem cell technology have contributed to disease modeling and drug screening via organoid technology. Organoid are defined as three-dimensional cellular aggregations derived from adult tissues or cells. They recapitulate the intricate pattern functionality of original tissue. Insulin is secreted mainly by pancreatic β Large-scale production insulin-secreting cells crucial for diabetes therapy. Here, we provide a brief overview organoids focus on recent advances protocols...
The economic feasibility of hydropower depends on the level energy production, which in turn weather conditions. Changes runoff volumes directly influence production. Therefore, decision makers should take into account different climate change scenarios when making investment decisions for existing plants. authors propose a real options-based framework to assess benefit adapting plants change. enables evaluation impacts hydropower. A case study South Korea shows that adaptation projects...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and it thus critical to identify novel molecular biomarkers HCC prognosis elucidate the mechanisms underlying progression. Here, we show that G-protein-coupled receptor 50 (GPR50) in overexpressed GPR50 knockdown may downregulate cancer cell progression through attenuation Notch signaling pathway. was found reduce by inactivating ligand-independent manner disintegrin metalloproteinase metallopeptidase domain...
Pluripotent stem cells (PSCs) offer a promising tool for regenerative medicine. The clinical application of PSCs inevitably requires large-scale culture in highly defined environment. present study aimed to devise coating materials the efficient adhesion and proliferation human (hPSCs). We tested activity seven fibronectin-derived peptides three laminin-derived attachment hPSCs through their immobilization on bottom dishes by creating fusion protein with mussel protein. Among extracellular...