A5021149057- Histone Deacetylase Inhibitors Research
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Wheat and Barley Genetics and Pathology
- RNA Interference and Gene Delivery
- Genetics and Plant Breeding
- Wnt/β-catenin signaling in development and cancer
- Sulfur Compounds in Biology
- Mangiferin and Mango Extracts
- Signaling Pathways in Disease
- Fungal and yeast genetics research
- Natural Antidiabetic Agents Studies
- Skin and Cellular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Phytochemicals and Antioxidant Activities
Yunnan Academy of Agricultural Sciences
2022
Konkuk University
2016-2019
Celltrion (South Korea)
2019
Although Keratin 19 (KRT19) has been reported as a tumor cell marker and found to interact with other proteins that modulate cancer properties, its role in prognosis remains be fully elucidated. We KRT19 expression was increased both colon breast cancer, but knockdown of showed opposing effects on properties. In resulted suppression via downregulation Wnt/Notch signaling without altering NUMB transcription. led an increase properties because attenuated Wnt enhanced Notch signaling....
Valproic acid (VPA), a well-known histone deacetylase (HDAC) inhibitor, is used as an anti-cancer drug for various cancers, but the synergistic effect of VPA and doxorubicin (DOX) combination treatment its potential underlying mechanism in hepatocellular carcinoma (HCC) remain to be elucidated. Here, we evaluate mono- combination-therapy effects DOX HCC identify specific efficient, anti-proliferative cells, especially HepG2 cells; this was not apparent MIHA normal hepatocyte cell line. The...
Eui Man Jeong, Ji-Woong Shin, Jisun Lim, Ju Hwan Kim, Hyewon Kang, Yingfu Yin, Hye-Mi YongHwan Sun-Gi Heun-Soo Dong-Myung Kihang Choi, In-Gyu Kim. IJSC 2019;12:367-79. https://doi.org/10.15283/ijsc18151
We evaluated the mono- and combination-therapy effects of valproic acid (VPA) doxorubicin (DOX) in hepatocellular carcinoma (HCC) identified a specific efficient, synergistic anti-proliferative effect VPA DOX combination HCC cells, especially HepG2 cells; this was not apparent MIHA normal hepatocyte cell line. The calculation coefficient drug interaction confirmed significant treatment. Concurrently, apoptotic death caused by treatment Hoechst nuclear staining western blot analysis caspase-3...
Ear-kernel size and weight are crucial components of grain yield in maize ( Zea mays L.). A nested association mapping (NAM) population was created by crossing a common founder Ye107 (male parent) with seven diverse donor parents which had huge ear-kernel differences. Genome-wide study (GWAS) were conducted for the NAM using 264,694 high quality single nucleotide polymorphisms (SNPs) generated genotyping-bysequencing method. total 11, 22 SNPs, identified GWAS, significantly associated ear...