A5100615128- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Thermoregulation and physiological responses
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Anorectal Disease Treatments and Outcomes
- Sexual function and dysfunction studies
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Neurotoxicity Research
- Optical Imaging and Spectroscopy Techniques
- Liver physiology and pathology
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Gastrointestinal motility and disorders
- Mesenchymal stem cell research
Konkuk University Medical Center
2017-2025
Dankook University
2023
CHA University
2023
CHA Bundang Medical Center
2023
Weill Cornell Medicine
2021
Institut Pasteur Korea
2020-2021
Konkuk University
2019-2021
Cornell University
2021
Seoul Medical Center
2018-2019
Busan TechnoPark
2018
Urinary tract infections (UTIs) account for almost 25% of in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance bacteriuria after antibiotics. To elucidate the basis these bacteria-independent bladder symptoms, we examined bladders rUTI. We noticed a notable increase neuropeptide content lamina propria indications enhanced nociceptive activity. In mice subjected to rUTI, observed sensory nerve sprouting that was...
Aims To assess the distinct histopathological characteristics and their clinical significance between non‐Hunner‐type Hunner‐type interstitial cystitis (IC)/bladder pain syndrome (BPS). Methods results We prospectively enrolled classified IC/BPS patients, on basis of cystoscopic findings, as having IC IC. Specimens obtained from posterior wall in cases during hydrodistension or Hunner/non‐Hunner lesions transurethral resection were evaluated. Stress urinary incontinence patients with...
Abstract Abuse of the hallucinogenic drug ketamine promotes development lower urinary tract symptoms that resemble interstitial cystitis. The pathophysiology ketamine-induced cystitis (KC) is largely unknown and effective therapies are lacking. Here, using a KC rat model, we show therapeutic effects human umbilical cord-blood (UCB)-derived mesenchymal stem cells (MSCs). Daily injection to Sprague-Dawley rats for 2-weeks resulted in defective bladder function, indicated by irregular voiding...
Abstract Interstitial cystitis/bladder pain syndrome (IC/BPS) is an intractable disease characterized by severe pelvic and urinary frequency. Mesenchymal stem cell (MSC) therapy a promising approach to treat incurable IC/BPS. Here, we show greater therapeutic efficacy of human embryonic (hESC)-derived multipotent cells (M-MSCs) than adult bone-marrow (BM)-derived counterparts for treating IC/BPS also monitor long-term safety in vivo properties transplanted M-MSCs living animals. Controlled...
Abstract Background The incidence of bladder cancer (BCa) is approximately four times higher in men than women. To develop effective BCa treatments, there an urgent need to understand the differences control mechanisms based on gender. Our recent clinical study showed that androgen suppression therapy using 5α-reductase inhibitors and deprivation affects progression, but underlying are still unknown. Methods mRNA expression levels receptor (AR) SLC39A9 (membrane AR) T24 J82 cells were...
Tweety family member 3 (TTYH3) is a calcium-activated chloride channel with non-pore-forming structure that controls cell volume and signal transduction. We investigated the role of TTYH3 as cancer-promoting factor in bladder cancer. The mRNA expression cancer patients was using various bioinformatics databases. results demonstrated increasingly greater worsened prognosis knockdown lines were constructed by their properties measured. significantly reduced proliferation sphere formation. Cell...
Mesenchymal stromal cells (MSCs) release extracellular vesicles (MSC-EVs) containing various cargoes. Although MSC-EVs show significant therapeutic effects, the low production of EVs in MSCs hinders MSC-EV-mediated development. Here, we developed an advanced three-dimensional (a3D) dynamic culture technique with exogenous transforming growth factor beta-3 (TGF-β3) treatment (T-a3D) to produce potent MSC-EVs. Our system enabled preparation a highly concentrated EV-containing medium for...
Functional bladder disorders including overactive and interstitial cystitis may induce problems in many other parts of our body such as brain gut. In fact, diagnosis is often less accurate owing to their complex symptoms. To have correct these diseases, we need understand the pathophysiology behind overlapped clinical presentation. First, focused on reviewing literatures that reported link between brain, patients with frequently accompanied mood depression anxiety. Second, reviewed described...
Purpose To evaluate the therapeutic effect of human embryonic stem cell (hESC)-derived multipotent mesenchymal cells (M-MSCs) on ketamine-induced cystitis (KC) in rats. Methods induce KC, 10-week-old female rats were injected with 25-mg/kg ketamine hydrochloride twice weekly for 12 weeks. In sham group, phosphate buffered saline (PBS) was instead ketamine. One week after final injection ketamine, indicated doses (0.25, 0.5, and 1×106 cells) M-MSCs (KC+M-MSC group) or PBS vehicle (KC directly...
The availability of autologous adult stem cells is one the essential prerequisites for human cell therapy. Urine-derived (USCs) are considered as desirable sources therapy because donor-specific USCs easily and non-invasively obtained from urine. Efficient isolation, expansion, differentiation methods necessary to increase their availability. Here, we developed a method efficient isolation expansion using Matrigel, rho-associated protein kinase (ROCK) inhibitor, Y-27632. prepared showed...
Purpose: Current guidelines recommend clean intermittent catheterization (CIC) at regular time intervals for patients with spinal cord injuries; however, many experience difficulties. Performing time-based CIC outside the home is a significant burden patients. In this study, we aimed to overcome limitations of current by developing digital device monitor bladder urine volume in real-time.Methods: The optode sensor near-infrared spectroscopy (NIRS)-based wearable intended be attached skin...
This study assessed the functional role of WNT genes and association between signalling cascades fibrosis in interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Twenty-five patients (3 males, 22 females; mean age 59.7 ± 10.9 years), included 7 non-Hunner-type IC (NHIC), 18 Hunner-type (HIC), 5 non-IC (control) groups. The expression sonic hedgehog, gene family, previously reported as biomarkers for IC/BPS were examined using RT-PCR biopsy specimens from mucosa submucosa layer...
The complexity of interstitial cystitis/bladder pain syndrome (IC/BPS) has led to considerable uncertainty in terms diagnosis and prevalence the condition. Here, we try identify IC/BPS-associated genes through an integrated analysis Gene Expression Omnibus (GEO) datasets confirm experimentally predict pathologic IC/BPS. Data mining GEO (GSE621, GSE11783, GSE28242, GSE57560) revealed a total 53 (51 upregulated two downregulated) common differentially expressed (DEGs) A protein-protein...
To determine the efficacy of intravesical hyaluronic acid (HA) instillation in treating patients with refractory interstitial cystitis/painful bladder syndrome (IC/PBS) and to identify any related factors that influence its therapeutic effect.Thirty-three female IC/PBS who demonstrated poor or unsatisfactory responses previous treatments between December 2010 October 2012 were enrolled. Despite treatments, enrolled had visual analogue scale (VAS) pain scores ≥4 total (symptom bother scores)...
Stress urinary incontinence (SUI) is a highly prevalent health condition that significantly impacts the quality of life. Traditional methods treatment for SUI, such as pubovaginal sling and Burch colposuspension, have been replaced by midurethral because its high efficacy, low complication morbidity rates, short learning curve. Although multiple behavioral operative treatments exist, slings are gold standard SUI in women. However, several reports raised concerns about complications caused...