A5020049566- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Xenotransplantation and immune response
- Phytochemistry and Biological Activities
- Medical Imaging Techniques and Applications
- Animal Genetics and Reproduction
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Breast Lesions and Carcinomas
- Head and Neck Anomalies
- Bone health and treatments
- MRI in cancer diagnosis
- Inflammatory mediators and NSAID effects
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Drug-Induced Hepatotoxicity and Protection
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Cancer Risks and Factors
Konkuk University Medical Center
2015-2025
Konkuk University
2015-2025
Korean Association of Thyroid and Endocrine Surgeons
2024
Cheongju University
2013-2022
Hanyang University
2015
Inje University Seoul Paik Hospital
2011-2013
Inje University
2011
National Institute of Food and Drug Safety Evaluation
2006-2010
Ministry of Food and Drug Safety
2006-2010
United States Food and Drug Administration
2010
Kidney-type glutaminase (GLS) and liver-type (GLS2) are dysregulated in many cancers, making them appealing targets for cancer therapy. However, their use as prognostic biomarkers is controversial remains an active area of research. Here, we performed a systematic multiomic analysis to determine whether glutaminases function human cancers. Glutaminase expression methylation status were assessed prominent functional protein partners correlated genes identified using various web-based...
This study elucidated possible mechanisms for the different anti-inflammatory potencies exhibited by water extracts of Eucommia ulmoides bark and Plantago asiatica seeds, which contain various iridoids. Water both herbal materials were tested in vitro with a battery assay models: lipopolysaccharide-induced thromboxane B(2) cyclooxygenase-1 (COX-1), prostaglandin E(2) cyclooxygenase-2 (COX-2), translocation nuclear factor-kappaB (NF-kappaB), tumor necrosis factor alpha (TNFalpha) nitric oxide...
Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration RK to male mice has been reported prevent high-fat diet-induced elevation in body weight and increase lipolysis white adipocytes. To elucidate possible mechanism for antiobesity action RK, its effects on expression secretion adiponectin, lipolysis, fatty acid oxidation 3T3-L1 were investigated. Treatment with 10 µM increased significantly differentiated cells. An immunoassay showed that both...
BRCA1/2 are breast cancer susceptibility genes that involved in DNA repair and transcriptional control. They dysregulated cancer, making them attractive therapeutic targets. Here, we performed a systematic multiomics analysis to expound functions as prognostic biomarkers cancer. First, using different web-based bioinformatics platforms (Oncomine, TIMER 2.0, UALCAN, cBioportal), the expression of was assessed. Then, R package used analyze diagnostic value patients. Next, determined...
To verify the anti-inflammatory potency of iridoids, seven iridoid glucosides (aucubin, catalpol, gentiopicroside, swertiamarin, geniposide, geniposidic acid and loganin) an aglycone (genipin) were investigated with in vitro testing model systems based on inhibition cyclooxygenase (COX)-1/-2 enzymes, tumor necrosis factor-α (TNF-α) formation nitric oxide (NO) production. The hydrolyzed-iridoid products (H-iridoid) β-gludosidase treatment only showed inhibitory activities, revealed different...
Context: Raspberry ketone (RK) is a natural phenolic compound of red raspberry. The dietary intake RK has been reported to exert anti-obese actions and alter the lipid metabolism in vivo human studies.Objective: To elucidate possible mechanism for RK, effects on adipogenic lipogenic gene expression 3T3-L1 adipocytes were investigated.Materials methods: maturing pre-adipocytes treated from day 2 8 differentiation mature 24 h 12 with 1, 10, 20, 50 μM RK. Triacylglycerols assessed by...
Abstract Background The incidence of bladder cancer (BCa) is approximately four times higher in men than women. To develop effective BCa treatments, there an urgent need to understand the differences control mechanisms based on gender. Our recent clinical study showed that androgen suppression therapy using 5α-reductase inhibitors and deprivation affects progression, but underlying are still unknown. Methods mRNA expression levels receptor (AR) SLC39A9 (membrane AR) T24 J82 cells were...
RAS mutations are the most common in thyroid nodules with indeterminate cytology by fine-needle aspiration (FNAC), and mutually exclusive BRAF mutations. However, diagnostic utility of mutation analysis is uncertain. We evaluated nodules.A total 155 (90 benign 65 indeterminate) negative for BRAF(V) (600E) on FNAC were analysed codon 61 using pyrosequencing methods. accuracy predicting malignancy based surgical pathologic diagnosis.Among -negative identified FNAC, 25 (38·5%) exhibited point...
Purpose: Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis.However, drugs to treat aggressive types of thyroid such as poorly differentiated or anaplastic have not yet been established.To that end, we analyzed effects berberine on human cell lines determine whether this compound useful treatment cancer.Materials Methods: The two 8505C TPC1, under adherent culture conditions, were for changes growth, cycle duration, degree apoptosis.Results:...
Tweety family member 3 (TTYH3) is a calcium-activated chloride channel with non-pore-forming structure that controls cell volume and signal transduction. We investigated the role of TTYH3 as cancer-promoting factor in bladder cancer. The mRNA expression cancer patients was using various bioinformatics databases. results demonstrated increasingly greater worsened prognosis knockdown lines were constructed by their properties measured. significantly reduced proliferation sphere formation. Cell...
Background Shear-wave elastography (SWE) has the potential to improve diagnostic performance of conventional ultrasound (US) in differentiating benign from malignant breast masses. Purpose To investigate false positive or negative results SWE masses and analyze clinical imaging characteristics with findings. Material Methods From May October 2013, 166 lesions 164 consecutive women (mean age, 45.3 ± 10.1 years) who had been scheduled for biopsy were included. Conventional US performed all...
Follicular variant of papillary thyroid carcinoma (FVPTC), particularly the encapsulated subtype, often causes a diagnostic dilemma. We reconfirmed molecular profiles in large number FVPTCs and investigated efficacy preoperative mutational analysis indeterminate nodules. BRAF V600E/K601E RAS was performed on 187 FVPTCs. Of these, 132 (70.6%) had point mutation one V600E (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The anticancer property and cytoprotective role of selenium in chemotherapy have been reported. However, the combination effects on for advanced breast cancer not yet clearly defined. purpose this study was to investigate combined using docetaxel cell lines.Under adherent culture conditions, two lines, MDA-MB-231 MCF-7, were treated with at 500pM 100nM, 1µM, or 10µM. Changes growth, cycle duration, degree apoptosis after 72 hours each group evaluated.In cells, therapy (docetaxel plus 10µM)...
The aim of this study is to know whether silibinin has an anticancer effect on triple negative breast cancer xenograft model using MDA-MB-468 cells.To establish the model, we injected cells into female Balb/c-nude mice. After establishing a oral was administered tested mice in way 200 mg/kg for 45 days. difference mean tumor volume between fed and control analyzed. epidermal growth factor receptor (EGFR) phosphorylation analyzed by Western blotting. expression VEGF, COX-2, MMP-9 genes tissue...