A5061469732- Cancer Cells and Metastasis
- Gut microbiota and health
- Identification and Quantification in Food
- Marine and fisheries research
- Berberine and alkaloids research
- Marine Bivalve and Aquaculture Studies
- Marine and Coastal Research
- Cephalopods and Marine Biology
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Genetic diversity and population structure
- Immunotherapy and Immune Responses
- Alkaloids: synthesis and pharmacology
- Prostate Cancer Treatment and Research
- Anesthesia and Pain Management
- PI3K/AKT/mTOR signaling in cancer
- Ichthyology and Marine Biology
- Reproductive biology and impacts on aquatic species
- Traditional and Medicinal Uses of Annonaceae
- Technology and Data Analysis
- MicroRNA in disease regulation
- Plant-based Medicinal Research
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- Vascular Malformations and Hemangiomas
Christchurch Hospital
2022
Ewha Womans University
2017-2021
Dongwha Pharm (South Korea)
2021
Ewha Womans University Medical Center
2018-2019
National Institute of Fisheries Science
2010-2017
Seoul National University
2007-2013
Konkuk University
2012
American Academy of Cosmetic Surgery
2012
Korea Fisheries Resources Agency
2010
Chosun University
2001
Invasion of cancer cell induced by matrix metalloproteinase-9 (MMP-9) is one pivotal steps in metastasis. Herein, we investigated how invasion was regulated berberine (BBR), an isoquinoline derivative alkaloid compound, MDA-MB-231 human breast cells. The basal level MMP-9 activity and expression dose-dependently increased TNF-alpha, while TNF-a-induced gelatinase decreased BBR. To investigate regulatory mechanism TNF-alpha-induced expression, pretreated cells with UO126 (MEK inhibitor),...
Purpose: Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis.However, drugs to treat aggressive types of thyroid such as poorly differentiated or anaplastic have not yet been established.To that end, we analyzed effects berberine on human cell lines determine whether this compound useful treatment cancer.Materials Methods: The two 8505C TPC1, under adherent culture conditions, were for changes growth, cycle duration, degree apoptosis.Results:...
: The microbiome is important in the development and progression of breast cancer. This study investigated effects derived from Klebsiella on endocrine therapy cancer using MCF7 cells. bacterial extracellular vesicles (EVs) that affect were established through experiments focused tamoxifen efficacy.
MEK-ERK pathway plays major roles in the progression of thyroid cancer, while use inhibitors has been limited by its toxicity. We investigated effect sodium selenite as an adjunct for to avoid toxicity ERK inhibitors.TPC1, 8505C and HTori-3 cells were treated with U0126 (MEK-ERK inhibitor) cell viability was counted Neubauer chamber. The synergistic effects also measured. expression ERK, p-ERK, p90RSK determined western blot.Treatment inhibited proliferation TPC1 a dose-dependent manner....
The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12–34% despite demonstrated effectiveness on improving the survival of patients HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play cytoprotective role normal cells. This study investigated selenium mechanism in relation Tz. cell lines, SK-BR-3 as trastuzumab-sensitive cells, JIMT-1 Tz-resistant were treated Tz sodium selenite...
Cancer recurrence is the main cause of chemotherapeutic treatment failure. The mechanisms driving cancer may be due to very rare subpopulation cells, stem-like cells (CSCs). Therefore, early detection and better are great interest. In this study, we investigated how eliminate side population (SP), which have characteristics also show chemotherapy resistance. Fluorescence-activated cell sorting (FACS) were used sort SP non-SP from human liver cancers, Huh-7 Hyaluronic acid (HA), an abundant...
Side population (SP) cells represent a rare among breast cancer cells. SP have been reported to act as stem‑like cells, and participate in the development of multidrug resistance via modulating expression ATP-binding cassette subfamily G member 2 (ABCG2). Dexamethasone is corticosteroid drug that has used an adjuvant treatment enhance efficacy chemotherapeutic agents; however, its effects yet be thoroughly investigated. In present study, dexamethasone were investigated using human MCF‑7 cell...
Lactobacillus casei (L. casei) is known to exert anti-proliferation effects on many types of cancer cells. However, the effect L. liver has not been reported. Accordingly, aim this study was determine anti-cancer extract Huh7 ATCC393 prepared and purified. After treatment cells, cell viability, cycle arrest death were analyzed by flow cytometry. The expression levels tumor necrosis factor-α receptor 1 (TNFR1) 3 (DR3) mRNA related with extrinsic apoptosis assessed reverse transcription...
Fishes were caught by a set net in the coastal waters off Yosu, Korea from April to October, 2001, and seasonal variation of abundance species composition studied. Fifty two identified as fish <TEX>$(89\%)\;cephalopods\;(10\%)\;and\;crustaeans\;(1\%).$</TEX> Of fishes Engraulis japonicus, Trachurus japonicus Trichiurus lepturus dominant representing <TEX>$64.1\%$</TEX> total number individuals. The was high spring low summer; individuals autumn. diversity index (H') 0.4-0.7 fluctuated...
Dendritic cells (DC) are a class of bone marrow-derived found in the blood, epithelia, and lymphoid tissues, most efficient antigen presenting cells. The number function DC can change dramatically cancer patients. aim this study is to correlate levels circulating subsets with clinical characteristics breast patients.Peripheral blood samples were collected from 53 untreated patients before surgery between January 2013 November 2013. Forty-one healthy, age-matched volunteers served as control...
Human adipose tissue or derived cells have been used clinically in several fields. Animal serum is storing and culturing human cells. Thus far, few problems associated with these sera current research However, animal may cause some clinical applications because of the toxic viruses proteins that can be present sera. plasma resolve serum. In this study, we investigated effects as a cryopreservation solution for tissues. We observed adherent from tissues were isolated effectively by...
Papillary thyroid cancer (PTC) has a high incidence of BRAFV600E mutation. The purpose this study was to evaluate the potential relationship between thyroiditis and mutation status in patients with PTC. We investigated how selective inhibitor PLX4032 affects proliferation inflammatory cytokine levels cancer.Two cell lines TPC1 8505C were treated PLX4032, an analysis done on growth, cycle, degree apoptosis, cytokines. To identify functional links BRAF, we used STRING database.Docking results...
Abstract Four specimens of unknown Coilia sp. were collected for the first time from Yellow Sea in 2008 and compared with mystus nasus. showed similar morphology to C. nasus, but differed that its tail was considerably shorter. We conducted an analysis morphological genetic characteristics effort clarify taxonomic position In counts measurements, well distinguished nasus by number scutes (42–44 vs. 40–45 45–55 nasus), ratio dorsal base length head (43.4–47.6 37.9–47.6 33.0–41.0), eye...
The family Ocythoidae is found throughout the temperate and subtropical waters of world's ocean contains a single species, Ocythoe tuberculata. Recently, female specimen rare pelagic species O. tuberculata was collected off Uljin in East Sea/Sea Japan Korea by squid jigging for first time. appearance this could be considered as evidence changes distribution sea surface. However, further studies are required to investigate whether phenomenon temporary or continuous.
Age and growth of purpulish Washington clam (Saxidomus purpuratus) was investigated from 480 samples monthly collected January to December 2002 in Jinhae Bay, Korea. Examination outer margins the shell revealed that translucent zone formed once a year March April, it can be used as annulus. Ages were determined ring radius shell, maximum age 9 years. The spawning period May October, main occurred July. relationship between length (SL) height (SH)...
This study investigated purplish Washington clam, Saxidomus purpuratus on its gonadal development, reproductive cycle and shell length (age) at 50% female group maturity from January to December 2011 in Jinhae Bay, Korea. species is dioecious. The gonad index (GI) began increase January, reached the maximum value May decrease June, minimum September then slowly October again. of clams can be divided into five successive stages: early active stage (Ea, February March), late (La, March...
We investigated the effects of fusidic acid (FA) on human cervical, thyroid, and breast carcinoma cell lines to determine potential usefulness FA in cancer treatment.Six (cervical cancer: Caski, HeLa; thyroid 8505C, TPC1; MCF-7, MDA-MB-231) were treated with FA. Furthermore changes growth, cycle duration, extent apoptosis analyzed.After treatment, cells showed a decrease growth rate. In death assay, populations similar each type after treatment FA, indicating that inhibition by was not...