The aim of this study was to evaluate the antidiabetic properties collagen hydrolysates (CHs). CHs exhibited dipeptidyl peptidase-IV inhibitory activity and stimulated glucagon-like-peptide-1 (GLP-1) secretion in vitro. We also determined whether improve glucose tolerance normal mice. Oral administration suppressed glycemic response during oral intraperitoneal tests (OGTT IPGTT), but effects were weaker IPGTT than OGTT. had no effect on gastric emptying rate. A pretreatment with GLP-1...

Objective The various functionalities of collagen peptides have generated a large interest in utilizing the bioactive as nutritional therapy to ameliorate physiological degenerative conditions. Collagen are observed reduce pain and aligned difficulties with respect osteoarthritis. Here we report enhanced ameliorating property novel high-functional “Wellnex” Type J following double-blind randomized active placebo-controlled 5-arm clinical trial ( n = 100) by using it supplement subjects knee...

Abstract Collagens act as cellular scaffolds in extracellular matrixes, and their breakdown products may also have important biological functions. We hypothesize that collagen dipeptide Pro-Hyp induces favorable healing activities examined the effects of administered via different routes on wound using our novel murine model, which an advanced fibrosis-prone scar lesion was developed abdominal muscle wall under skin. After excising a part wall, free-drinking experiment performed solutions...

This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49-63 years. The primary outcome measures were healthcare quotients based gray matter volume (GM-BHQ) fractional anisotropy (FA-BHQ). secondary changes in scores between week 0 word list memory (WLM) standard verbal paired associate learning (S-PA) tests as well physical,...

In this randomized, double-blind, placebo-controlled study, we investigated the effects of collagen peptides (CP) containing high concentrations prolyl-hydroxyproline and hydroxyprolyl-glycine on advanced glycation end products (AGEs) levels in skin subcutaneous blood vessel walls. A total 31 individuals aged 47-87 years were randomly assigned to receive either 5 g/day fish-derived CP or a placebo for 12 weeks. Body compositions AGEs measured at beginning study. No adverse events observed,...

We examined the effect of 5.0 g/day collagen peptide (CP) or fermented with Aspergillus sojae (FCP) on skin pigmentation in healthy participants.In this randomized, double-blind, placebo-controlled study, 44 men and women aged 25-63 years were placed into three groups by stratified random allocation treated CP, FCP, placebo (PL) at for 3 months. Their condition was measured monthly from baseline to months intake.No adverse events identified any group. The CP group showed a significant...

Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute an innovative class of oral agents for the treatment Type 2 Diabetes Mellitus (T2DM). DPP-4 increase glucagon-like peptide-1 (GLP-1) availability and correct “incretin defect” seen in T2DM patients. Peptides derived from collagen have been reported to inhibitory properties. A double blind randomized trial has conducted evaluate effectiveness Collagen peptides (CPT) as nutritional supplement subjects with T2DM. Resistant dextrin (RD), a...

본 연구에서는 Tilapia fish에서 얻은 콜라겐 펩타이드 (TFCP)의 섭취가 UVB를 조사한 무모생쥐에서 어떠한 효과를 나타내는지 확인하고자 하였다. 무모생쥐에 1주일에 3번 조사하여 광노화를 유도하였고, TFCP 545, 1090 mg/kg을 매일 총 12주간 경구투여 후, 주름생성, 피부 두께, 홍반, 수분량, 하이드록시프롤린, MMPs 및 filaggrin의 발현량을 측정하였다. UVB만 조사 한 군과 비교하여 조사하고 펩타이드를 섭취시킨 군에서 두께 홍반이 감소하였고 수분량은 증가하였다. 또한, 콜라젠 양과 하이드록시프롤린의 양도 TFCP를 섭취한 UVB 조사군에 비해 유의하게 회복되는 것을 확인하였다. 자외선에 의해 활성화되는 MMP-2, MMP-9 뿐만 아니라 MMP-3, MMP-13의 mRNA 발현량이 억제됨을 확인하였고, 단백질 발현량도 이러한 결과들을 통하여 TFCP의 섭취는 의한 주름 생성을 억제하고 손상을 회복시킨다는 따라서, TFCP는 피부미용식품...

Hypertrophic scars found on the human body rarely develop in experimental animals, possibly due to their looser skin structure. This makes it difficult understand genesis of scar lesions. Therefore, appropriate animal models are urgently needed. In this study, we established a novel model scar-forming wound by resecting small portion abdominal muscle wall lower center abdomen C57BL/6N mice, which exposed contractive forces surrounding tissue. As low-tension control, back excision was used...

This study was conducted to evaluate the efficacy of different doses Bioactive Collagen Peptide (BACP) in Monoiodo Acetic Acid (MIA) induced Osteoarthritis (OA) rats comparison with conventional (CP).Animals were supplemented daily CP (1033 mg/kg) and BACPs a dosage 1033mg/kg, 517mg/kg, 258 mg/kg, 103mg/kg which are equivalent human 10g, 5g, 2.5g 1g respectively.Etoricoxib (10mg/kg) used as reference drug.Different parameters such Rotarod fall latency, heat hyperalgesia, cold...

Abstract Active collagen oligopeptides are bioactive collagen-derived peptides detected by a recently-established ELISA. To facilitate studies of the function and metabolism these products, this study aims to determine which is recognized novel anti-ACOP antibody used in We then investigate effect peptide (CP) ingestion exercise on urinary ACOP concentrations cohort university student athletes using colorimetric, LC-MS/MS, observed that showed strong cross-reactivity Pro-Hyp Gly-Pro-Hyp weak...

Abstract Active collagen oligopeptides (ACOP) are bioactive collagen-derived peptides detected by a recently-established ELISA. To facilitate studies of the function and metabolism these products, this study aims to determine which is recognized novel anti-ACOP antibody used in We then investigate effect peptide (CP) ingestion exercise on urinary ACOP concentrations cohort university student athletes using colorimetric, LC–MS/MS, observed that showed strong cross-reactivity Pro-Hyp...

Oral ingestion of collagen hydrolysate has various benecial effects. We developed a novel fermented peptide (FCP), different from the conventional peptides, by fermenting gelatin with Aspergillus sojae. This study aimed to investigate effect FCP in inhibiting fat accumulation under high-fat loading. Male C57BL/6J mice were fed low- or diet, diet including 5% for 28 d. Body weight, visceral adiponectin levels, leptin concentration, fatty acid synthase (FAS) activity, and carnitine...

Abstract Scar tissue formation is a result of excess healing reactions after wounding. Hypertrophic scars scarcely develop in mouse. In the present study, we established novel experimental model scar-forming wound by resecting small portion abdominal wall on lower center abdomen, which exposed contractive forces surrounding muscle tissue. As tension-less control, back-skin excision was used with splint fixed onto excised skin edge, and granulation formed facia supported back skeleton. One...

Abstract Collagens act as cellular scaffolds in extracellular matrixes, and their breakdown products may also have important biological functions. We hypothesize that collagen dipeptide Pro-Hyp induces favorable healing activities examined the effects of administered via different routes on wound using our novel murine model, which an advanced fibrosis-prone scar lesion was developed abdominal muscle wall under skin. After excising a part wall, free-drinking experiment performed solutions...