A5084302861- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Textile materials and evaluations
- Muscle metabolism and nutrition
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Body Composition Measurement Techniques
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Liver physiology and pathology
- Heart Failure Treatment and Management
- Carcinogens and Genotoxicity Assessment
- Cardiac Ischemia and Reperfusion
- Frailty in Older Adults
- Heart Rate Variability and Autonomic Control
- Liver Disease and Transplantation
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Sphingolipid Metabolism and Signaling
Ehime University
2016-2025
Asahikawa Medical University
2011-2023
Ritsumeikan University
2019-2022
St. Marianna University School of Medicine
2021
Palmetto Hematology Oncology
2017
Aichi Medical University
2017
Hyogo Prefectural Nishinomiya Hospital
2017
National Center for Tumor Diseases
2016
Kyoto University
2014
National Center For Child Health and Development
2014
Background— Stratification of pediatric patients with congenital heart disease (CHD) has been based on their hemodynamics and/or functional capacity. Our purpose was to compare cardiac autonomic nervous activity (CANA) and neurohormonal activities (NHA) postoperative status in stable CHD biventricular physiology. Methods Results— We divided 379 subjects (297 patients, 28 dilated cardiomyopathy patient, 54 control subjects) into 4 subgroups according New York Heart Association (NYHA) class...
Abstract Background There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to development impairment unclear. We investigated possible muscle mass decline in cross‐sectional study 1518 subjects aged 55 years or above. also evaluated arterial stiffness white matter hyperintensities (WMHs) as mechanisms for this association. Methods Two sarcopenic indices were measured: thigh area (CSA; calculated by computed tomography)...
Plasma brain natriuretic peptide (BNP) is used as a marker of congestive heart failure. Moreover, plasma BNP levels are increased in patients with acute ischemic stroke, particular, cardioembolic stroke. We investigated whether the level can also be biological to differentiate specific stroke subtype, particular from other subtypes.Consecutive (total 200; 124 males, 76 females; mean age, 71.4 years) within 24 hours onset were prospectively enrolled. measured on admission. Patients divided...
We report a 10‐year‐old male with relapsing Ph‐like acute lymphoblastic leukemia (ALL) bearing ATF7IP/PDGFRB translocation. He was refractory to conventional therapy, and finally treated single‐agent second‐generation TKI dasatinib. The therapeutic response prompt, the disappearance of minimum residual disease (MRD) based on genomic PCR analysis within 3 months, he has maintained complete molecular remission for 12 months. This case describes an early‐phase monotherapy ALL, technical tips...
MYC activation at modest levels has been frequently found in hepatocellular carcinoma. However, its significance hepatocarcinogenesis remained obscure. Here we examined the role of Myc mouse liver tumours induced by hepatocytic expression myristoylated AKT (AKT) and/or mutant HRASV12 (HRAS) via transposon-mediated gene integration. or HRAS alone required 5 months to induce tumours, whereas their combination generated carcinoma within 8 weeks. Co-introduction and lipid-laden preneoplastic...
One-leg standing time (OLST) has been frequently used physical performance measure; however, what muscular characteristics OLST represents remains uncertain. This cross-sectional study aimed to investigate the association between and muscle clarify possibility of using as a measure. Study participants comprised 1144 older adults aged 65 years or older. Computed tomography images provided mid-thigh skeletal area mean attenuation value. was measured for maximum 60 s. Static postural...
An incomplete circle of Willis (CoW) is associated with ischemic stroke severity and patient prognosis. However, the clinical significance an CoW in healthy adults remains unclear. We examined association between cognitive decline community-dwelling, apparently healthy, older adults. A cross sectional study 829 functionally independent ≥50 years (mean age: 67.4 ± 8.2 years) who voluntarily participated health checkup program provided by Anti-Aging Center Ehime University Hospital. Variations...
Objective: Increasing blood pressure (BP) variability is reported to be a cardiovascular risk factor. However, the clinical implications of postprandial hypotension (PHYPO), commonly observed BP in elderly persons, are poorly understood. Here, we investigated possible associations between decline and asymptomatic cerebral damage community residents. Methods: Study participants consisted 1308 general residents (65 ± 9 years old). Postprandial change was calculated from SBP measured just...
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared mRNA expression profiles of mouse hepatocellular tumors induced by repeated injection CC l 4 a single diethylnitrosamine ( DEN ) using cDNA microarray. We identified tumor‐associated genes that were expressed differentially cirrhotic model H19 , Igf2 Cbr3 and Krt20 non‐cirrhotic Tff3 Akr1c18 Gpc3 Afp Abcd2 as well...
Activation of the phosphoinositide 3-kinase–AKT, Yes-associated protein (YAP), and MYC pathways is involved in human liver cancers, including hepatocellular carcinoma (HCC) cholangiocarcinoma (CC). However, nature interactions among these has remained poorly understood. Herein, we demonstrate coordination during formation mouse tumors induced by hepatocyte-specific somatic integration myristoylated AKT, mutant YAP, Myc, or their combinations. Although introduction YAP Myc alone was...
Background and Purpose We investigated whether the plasma brain natriuretic peptide (BNP) level on admission can serve as a biological marker of in-hospital death in patients with acute ischemic stroke. Methods prospectively enrolled 335 consecutive (125 females; mean age, 72.3 years) stroke within 24 hours onset measured BNP admission. Patients were divided into two groups: deceased group, who died during hospitalization; survival group. The factors associated by multivariate logistic...
Background and purpose: We investigated whether the brain natriuretic peptide (BNP) level can serve as a predictive biological marker of delayed atrial fibrillation (AF). Methods: Two hundred thirty seven consecutive patients admitted to our institution with acute ischaemic stroke or transient attack (TIA) within 24 h onset were enrolled. The classified according presence absence AF upon admission [AF sinus rhythm (SR) groups]. SR group was subdivided based on development after (new‐ non‐AF...
Asymptomatic cerebral small-vessel disease (cSVD) in elderly individuals are potent risk factors for stroke. In addition to common clinical factors, postural instability has been postulated be associated with cSVD older frail patients. Here, we conducted a cross-sectional study understand the possible link between and asymptomatic further, namely periventricular hyperintensity, lacunar infarction, microbleeds, as well cognitive function, middle-aged general population (n=1387).Postural was...
We observed a 41-year-old woman with severe central pontine myelinolysis (CPM) and unusually extensive extrapontine (EPM), but without evidence of hyponatremia. Increased alcohol consumption in prior months was the main cause her CPM/EPM. However, general, EPM is rare accompaniment alcoholic patients CPM With regard to our patient, widespread; magnetic resonance imaging (MRI) brain showed multiple hyperintense lesions on T2-weighted images distributed symmetrically bilateral caudate nuclei,...
<b><i>Background and Purpose:</i></b> Our previous retrospective study demonstrated that a brain natriuretic peptide (BNP) level of >140 pg/ml on admission was useful to distinguish cardioembolism (CE) from non-CE. The aim the present prospectively investigate utility this predefined threshold. <b><i>Method:</i></b> Two hundred twenty-one consecutive patients were enrolled. On admission, BNP levels measured classified according low (≤140.0...
LEOPARD syndrome (LS) is an autosomal dominant inherited multisystemic disorder. Most cases involve mutations in the PTPN11 gene, which encodes protein tyrosine phosphatase Src homology 2-containing 2 (SHP2). LS frequently causes severe hypertrophic cardiomyopathy (HCM), even from fetal period. However, molecular pathogenesis has not been clearly elucidated. Here, we analyzed roles of LS-type SHP2 mutant Gln510Glu (Q510E), showed most type HCM LS, cardiomyocyte differentiation, and...