A5075822021- Protein Hydrolysis and Bioactive Peptides
- Osteoarthritis Treatment and Mechanisms
- Skin Protection and Aging
- Diagnosis and Treatment of Venous Diseases
- Pressure Ulcer Prevention and Management
- Collagen: Extraction and Characterization
- Muscle metabolism and nutrition
- Peptidase Inhibition and Analysis
- Biotin and Related Studies
- Tendon Structure and Treatment
- Advanced Glycation End Products research
- Peroxisome Proliferator-Activated Receptors
- Contact Dermatitis and Allergies
- Protein purification and stability
- Cell Adhesion Molecules Research
- Diabetes Treatment and Management
- Body Contouring and Surgery
- Knee injuries and reconstruction techniques
- Consumer Attitudes and Food Labeling
- Neurological Disorders and Treatments
- Chemical Synthesis and Analysis
- Muscle Physiology and Disorders
- Meat and Animal Product Quality
- Textile materials and evaluations
- Dermatology and Skin Diseases
Peptide Institute (Japan)
2011-2016
Recent studies show that enzymatically hydrolysed collagen, the collagen peptide, is absorbed and distributed to joint tissues has analgesic anti-inflammatory properties. A double-blind, placebo-controlled, randomised trial with peptides isolated from pork skin (PCP) bovine bone (BCP) sources was carried out study effectiveness of orally supplemented peptide control progression osteoarthritis in patients diagnosed knee osteoarthritis. Improvement treatment assessed reduction Western Ontario...
BACKGROUND Several human studies have demonstrated occurrence of two major collagen peptides, prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly), in peripheral blood. Some vitro that Pro-Hyp Hyp-Gly exert chemotaxis on dermal fibroblasts enhance cell proliferation. Additionally, enhances the production hyaluronic acid by fibroblasts. These findings suggest amounts blood are important factors to show efficacy hydrolysates skin health. RESULTS We conducted a randomised...
A number of studies have shown that oral administration collagen hydrolysate (CH) results in the absorption di- and tri-peptides. In order to understand dynamics CH metabolism, molecular profiles hydroxyproline (Hyp) Hyp-containing peptides (HCPs) were analyzed by situ perfusion rat intestine liver. The total amount absorbed HCPs during 1 h was 16.6 μmol, which significantly higher than free Hyp (6.6 μmol). addition, also reliably detected hepatic perfusate at level Hyp. Thus, demonstrated...
The aim of this study was to evaluate the antidiabetic properties collagen hydrolysates (CHs). CHs exhibited dipeptidyl peptidase-IV inhibitory activity and stimulated glucagon-like-peptide-1 (GLP-1) secretion in vitro. We also determined whether improve glucose tolerance normal mice. Oral administration suppressed glycemic response during oral intraperitoneal tests (OGTT IPGTT), but effects were weaker IPGTT than OGTT. had no effect on gastric emptying rate. A pretreatment with GLP-1...
Abstract We conducted a double blind, multi-centric, placebo-controlled, randomized trial to compare the Pressure Ulcer Scale for Healing (PUSH) and Sore Status Tool (PSST) scores wound area measurements at 16 weeks of subjects with pressure ulcers who were given standard care plus one two types collagen hydrolysate (CH-a), which contained low levels prolylhydroxyproline (Pro-Hyp) hydroxyprolylglycine (Hyp-Gly), CH-b, high Pro-Hyp Hyp-Gly) placebo group. A total 120 stage II or III entered...
Collagen is an extracellular matrix protein present in the skin, tendon, cartilage and bone. peptides (CP) are produced by hydrolysis of gelatin (heat-denatured collagen) proteases utilized as a component nutraceuticals. The current study investigated effect CP on articular OA evaluating serum levels biomarkers (CTX-II for type II collagen degradation CPII synthesis), histopathological changes (Mankin score, based toluidine blue staining proteoglycans), immunohistochemical metalloproteinase...
This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49-63 years. The primary outcome measures were healthcare quotients based gray matter volume (GM-BHQ) fractional anisotropy (FA-BHQ). secondary changes in scores between week 0 word list memory (WLM) standard verbal paired associate learning (S-PA) tests as well physical,...
Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute an innovative class of oral agents for the treatment Type 2 Diabetes Mellitus (T2DM). DPP-4 increase glucagon-like peptide-1 (GLP-1) availability and correct “incretin defect” seen in T2DM patients. Peptides derived from collagen have been reported to inhibitory properties. A double blind randomized trial has conducted evaluate effectiveness Collagen peptides (CPT) as nutritional supplement subjects with T2DM. Resistant dextrin (RD), a...