Axon regenerative capacity diminishes with aging and differences in the condition of peripheral nerves between young elderly individuals have been reported. However, underlying pathology remains unclear. The expression repressor element‑1 silencing transcription factor (REST) increases age is reported to suppress axon regeneration. present study investigated potential treatment reduced using REST‑regulated cells a mouse model. This examined molecular janus kinase 1 (JAK1)/signal transducer...

Summary: Robotics allows up to 40× visual magnification and 10× of the surgeon's movements, eliminates physiologic tremors. These properties should allow development mini-invasive limb surgery, especially brachial plexus. The purpose this work was test feasibility restoration elbow flexion according technique Oberlin using a da Vinci robot. authors' series included four patients (average age, 31 years) presenting with paralysis. They were operated on 8 months after injury S In three...

Journal Article Increased neutral protease and collagenase activity in recessive dystrophic epidermolysis bullosa Get access K. TAKAMORI, TAKAMORI Department of Dermatology, School Medicine, Juntendo University, Tokyo 113, Japan Kenji Takamori, M.D., Ph.D., 2‐1‐1 Hongo, Bunkyo‐ku, Japan. Search for other works by this author on: Oxford Academic Google Scholar NAITO, NAITO A. TANEDA, TANEDA H. OGAWA British Volume 108, Issue 6, 1 June 1983, Pages 687–694,...

Collagen is an extracellular matrix protein present in the skin, tendon, cartilage and bone. peptides (CP) are produced by hydrolysis of gelatin (heat-denatured collagen) proteases utilized as a component nutraceuticals. The current study investigated effect CP on articular OA evaluating serum levels biomarkers (CTX-II for type II collagen degradation CPII synthesis), histopathological changes (Mankin score, based toluidine blue staining proteoglycans), immunohistochemical metalloproteinase...

The management of distal radius fractures has dramatically improved due to the development a locking plate system. In addition, mini-invasive surgery been performed in lot surgical fields recent years. aim present study is investigate possibility fixation fracture with volar through 10 mm approach. Eighteen patients (mean age: 66 y; range, 28 88 8 males and females) were operated on using plate. incision for plating was always long. clinical, cosmetic, radiologic outcomes investigated. At 3...

To evaluate the biological changes in tendons during aging process, present study examined effect of on tendon structure, distribution collagen types I and III, expression tendon‑associated genes, using flexor a mouse model. Histological assessment structure III were performed, genes was evaluated digitorium longus young (8 weeks) aged (78 female C57BL/6 mice. The results indicated that Soslowsky score, based analysis cellularity, fibroblastic changes, fiber orientation disruption,...

The current tendency of microsurgery is heading toward supermicrosurgery and assisted by robotics. aim this work was to study the feasibility a free hallux hemipulp transfer with surgical robot in cadaveric model. We used human body. intervention realized Da Vinci SI^® (Intuitive Surgical™, Sunnyvale, CA) two stages: first taking off medial hemipulp, then transferring radial thumb hemipulp. lasted 1 hour 59 minutes, exclusively robot, without any interruption or outside...

The treatment of ulnar nerve compression at the elbow remains controversial. No single technique has yet proven its superiority. We describe a combining advantages mini-invasive approach with those transposition. present results 30 patients, mean age 52 years, who underwent anterior subcutaneous transposition using follow-up more than six months. incision measures 3 cm. were evaluated by measuring pain intensity, quick disabilities arm shoulder and hand (DASH), grip strength pinch, McGowan...

The specific factors which induce blister formation in recessive dystrophic epidermolysis bullosa (RDEB) and simplex (EBS) were studied by culturing normal human skin with fluid from patients RDEB EBS. When a healthy person was cultured fluid, it developed clean subepidermal histology similar to that of blister. factor(s) induced this inactivated heat (60°C, 30 min), trypsin digestion treating EDTA, EGTA, α2‐macroglobulin, soybean inhibitor (SBTI) or N‐ethylmaleimide (NEM), but not affected...

In the present study, effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides type II collagen (CTX‑II), propeptides procollagen (CPII), N‑terminal I (NTx) alkaline phosphatase (BAP). The results indicate that CPII (a marker synthesis) not substantially changed, however, CTX‑II degradation) reduced by administration, particularly at a...

In the present study, thenar muscles were evaluated using magnetic resonance imaging (MRI), in addition, correlations between muscle changes, clinical findings and electrodiagnostic results from patients with carpal tunnel syndrome investigated. The subjects 13 (17 wrists) who clinically diagnosed syndrome. all patients, a medical history was obtained physical examination performed, addition to assessment Kapandji scoring system, visual analogue scale (VAS), quick-disabilities of arm,...

Brachial plexus surgery requires extensive incisions. They are esthetically unsightly and compromise the quality of recovery after nerve repair surgery. We present a new approach to brachial using mini-invasive robot-assisted perform biopsy an intraneural perineurioma right in 12-year-old girl.

Organ cultures of normal human skin incubated with blister fluid from a patient epidermolysis bullosa simplex (EBS) produced clean intra-epidermal histology similar to that an EBS blister.

The influence of aging on the induction nerve regeneration in artificial conduits has yet to be clarified. In present study, conduit transplantation and histological analysis using sciatic young elderly mice were performed. Using 20 male C57BL/6 mice, an was transplanted at 8 weeks (Young group) or 70 age (Aged group), evaluated histologically 1, 4 12 after surgery. hematoxylin eosin staining, state evaluated. Additionally, immunohistochemical staining used investigate angiogenic marker...

Treatment of volar-displaced distal radius fractures (DRF) accompanied by marginal rim fragment has recently been actively discussed. It is difficult to obtain a sufficient buttress effect on this fragment. Therefore, we apply volar locking plate (DVLP) with Here, report the treatment outcomes and caveats surgery

It is usual to stop the intake of oral anticoagulants (anti-vitamin K) before surgery. Some authors have shown that during minimal surgery, relay with low molecular weight heparin (LMWH) may lead more thromboembolic complications. We present a prospective comparative study while evaluating results stopping or continuing in surgery for carpal tunnel syndrome.Our series included 21 patients (24 hands) taking on long-term basis. For first nine (group I), treatment was stopped following 12 II),...

Background: The upper limb surgery under the ultrasound-guided brachial plexus block is becoming popular due to its safety, effectiveness, and convenience. However, uneven distribution of anesthesiologists become a social problem. Ultrasound-guided by surgeons has been widespread especially in hand surgeons. We report surgical treatment distal radius fractures performed our hospital. Methods: subjects were 101 patients (41 males 60 females, average age 61.6 years) who underwent for...

The origin and properties of the blister formation factor in recessive dystrophic epidermolysis bullosa (RDEB) fluids were investigated. Organ cultures normal human skin incubated with RDEB dermis extract or fibroblast culture medium (FCM) produced a clear subepidermal histology similar to that vivo. injection into guinea-pig also induced dermal-epidermal separation lesions patients. forming activity FCM which induces was inactivated by heat (60 degrees C for 30 min), trypsin digestion...

Introduction : Although vascularized bone grafting (VBG) using 1, 2 intercompartmental supraretinacular artery (1, ICSRA) is effective for scaphoid nonunion, dorsal intercalated segment instability (DISI) deformity persists even after correction of humpback (HD). The purpose this retrospective study was to evaluate the HD and DISI ICSRA VBG nonunion. Methods We treated 18 patients (mean age: 25.8, 16 males females) with nonunion a 2-ICSRA between January 2010 December 2018. average time from...