A5037688368- Mycotoxins in Agriculture and Food
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Aortic Thrombus and Embolism
- Neurological Disease Mechanisms and Treatments
- Plant Pathogens and Fungal Diseases
- Cardiac tumors and thrombi
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrhythmias and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Nerve injury and regeneration
- Alcohol Consumption and Health Effects
University of Yamanashi
2023-2025
Nagoya Municipal Industrial Research Institute
2025
Juntendo University
2015-2024
University of Yamanashi Hospital
2023-2024
Dokkyo Medical University
2023
Juntendo University Urayasu Hospital
2013-2023
Jichi Medical University
2009-2023
National Cerebral and Cardiovascular Center
2023
Kyorin University
2023
Tokyo Women's Medical University
2023
The role of metabolic diseases in ischemic stroke has become a primary concern both research and clinical practice. Increasing evidence suggests that dysbiosis is associated with diseases. aim this study was to investigate whether the gut microbiota, as well concentrations organic acids, major products dietary fiber fermentation by are altered patients stroke, examine association between these changes host metabolism inflammation. We analyzed composition fecal microbiota acids 41 40 control...
Journal Article INVOLVEMENT OF GENETIC POLYMORPHISM ALCOHOL AND ALDEHYDE DEHYDROGENASES IN INDIVIDUAL VARIATION METABOLISM Get access YASUHIKO MIZOI, MIZOI *Departmetn of Legal Medicine, Osaka Medical College2-7 Daigaku-machi, Takatsuki, 569, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar KENJI YAMAMOTO, YAMAMOTO †Kobe University School TsukubaJapan YASUHIRO UENO, UENO TATSUSHIGE FUKUNAGAI, FUKUNAGAI ‡Shiga Science, SHOJI HARADA §Institute Community...
By adopting a single-spore isolation technique, 113 isolates of Gibberella zeae, the perfect stage Fusarium graminearum, were isolated from rice stubbles in barley and wheat fields tested for production trichothecenes zearalenone on grains. Of isolates, 93% produced trichothecenes, they could be subdivided into two chemotaxonomic groups: nivalenol fusarenon-X producers deoxynivalenol 3-acetyldeoxynivalenol producers. No cross these types was observed isolates. Zearalenone detected 68% but no...
MicroRNAs (miRNAs) regulate dendritogenesis and plasticity. However, the biological function of miRNAs in axons has not been extensively investigated. Here, using rat primary cortical neurons cultured a microfluidic chamber, we found that distal expressed miR-17–92 cluster, proteins production activity mature miRNAs, Dicer Argonaute 2, respectively, were present axons. Overexpression cluster substantially increased axonal outgrowth, whereas attenuation endogenous miR-19a, key miRNA with...
Background and Purpose— Axonal remodeling is critical to brain repair after stroke. The present study investigated axonal outgrowth stroke the signaling pathways mediating in cortical neurons. Methods— Using a rodent model of middle cerebral artery occlusion, we examined high-molecular weight neurofilament (NFH) immunoreactive axons myelin basic protein-positive oligodendrocytes peri-infarct area. In vitro, using cultured neurons microfluidic chamber challenged by oxygen-glucose deprivation...
Abstract As oligodendrocyte precursor cells (OPCs) are vulnerable to ischemia, their differentiation oligodendrocytes (OLG) is impaired in chronic cerebral hypoperfusion. Astrocyte–OLG interaction important for white matter homeostasis. Recently, reactive astrocytes were separated into two types, A1 (cytotoxic) and A2 (neurotrophic). However, role prolonged hypoperfusion remains unclear. We analyzed the effects of between A1–A2 OPC–OLG under hypoperfusion, focusing on mitochondrial...
Background and Purpose— Exosomes play a pivotal role in neurogenesis. In the peri-infarct area after stroke, axons begin to regenerate but are inhibited by astrocyte scar formation. The direct effect underlying molecular mechanisms of astrocyte-derived exosomes on axonal outgrowth ischemia not known. Methods— Using semaphorin 3A (Sema3A) inhibitor, we explored neuronal signaling during rats subjected middle cerebral artery occlusion cultured cortical neurons challenged with oxygen-glucose...
Lipopolysaccharide (LPS) is a major component of the outer membrane Gram-negative bacteria and potent inflammatory stimulus for innate immune response via toll-like receptor (TLR) 4 activation. Type 2 diabetes associated with changes in gut microbiota impaired intestinal barrier functions, leading to translocation microbiota-derived LPS into circulatory system, condition referred as metabolic endotoxemia. We investigated effects endotoxemia after experimental stroke transient middle cerebral...
A liquid chromatographic (LC) method for simultaneous determination of fumonisins B1 (FB1), B2 (FB2), and B3 (FB3) in corn was subjected to a collaborative study involving 12 participants from 10 countries, which the accuracy reproducibility characteristics were established. Mean analyte recoveries ranged 81.1 84.2% FB1 (at spiking range 500 8000 ng/g), 75.9 81.9% FB2 200 3200 75.8 86.8% FB3 100 1600 ng/g). The valid data statistically evaluated after exclusion outliers. Relative standard...
The proto-oncogene c-myb encodes a nuclear protein which binds to DNA.Here we find that bacterially synthesized one site of the simian virus 40 enhancer.
Twelve T-2 toxin-producing isolates and four fusarenon-X-producing of Fusarium species were examined for their ability to produce trichothecene mycotoxins in shake culture jar fermentation. toxin producers such as solani, F. sporotrichioides , tricinctum produced neosolaniol semisynthetic medium. solani M-1-1 the largest amount a nutrient medium consisting 5% glucose (or sucrose), 0.1% peptone, yeast extract either or fermentation at 24 27 C 5 days. None significant amounts fusarenon-X cultures.
Abstract Serum response factor (SRF) is a transcription that transactivates actin‐associated genes and has been implicated in oligodendrocyte (OL) differentiation. To date, it not investigated cerebral ischemia. We the dynamics of SRF expression after stroke vivo role OL differentiation vitro . Using immunohistochemistry, we found was upregulated OLs precursor cells (OPCs) stroke. Moreover, upregulation concurrent with downregulation micro‐RNAs (miRNAs) miR‐9 miR‐200 family ischemic white...
Chronic cerebral hypoperfusion causes white-matter lesions (WMLs) with oxidative stress and cognitive impairment. However, the biologic mechanisms that regulate axonal plasticity under chronic have not been fully investigated. Here, we investigated whether L-carnitine, an antioxidant agent, enhances oligodendrocyte expression, explored signaling pathways mediate in a rat model. Adult male Wistar rats subjected to ligation of bilateral common carotid arteries (LBCCA) were treated or without...
To evaluate the accuracy of recently proposed diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).We enrolled 42 patients hindbrain punctate and/or linear enhancements (<3 mm in diameter) and tested CLIPPERS criteria.After a median follow-up 50 months (IQR 25-82), 13 out were CLIPPERS-mimics: systemic central nervous system lymphomas (n=7), primary angiitis (n=4) autoimmune gliopathies (n=2). The sensitivity...
The correlation among degrees of alcohol intoxication, facial flushing, blood concentration (BAC) and acetaldehyde level was studied in 117 male alcoholic patients who underwent various tests to assess influence. Blood samples were collected levels determined. BACs ranged from 29 577 mg/dl all 200 299 48 them. Fifty-one could stand erect (mean BAC [+/- SD] = 189 +/- 80 mg/dl), while showed apparently normal reaction a walking turning test 192 78 mg/dl). Some the cases having over 300 still...
The procedure for biological and chemical detection of trichothecene-type mycotoxins its application to the screening Fusarium toxic strains were described.