Purpose Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Recently, overexpression programmed cell death 1 (PD-1) and PD-1 ligand (PD-L1) has been shown to correlate with poor prognosis in many cancers. However, expression PD-L1 or 2 (PD-L2) clinical outcomes have not fully investigated HCC. Materials Methods Formalin-fixed paraffin-embedded samples were obtained from 85 patients HCC who underwent surgery. The PD-Ls (PD-L1, PD-L2) was evaluated by immunohistochemical...

Microporous calcium phosphate based synthetic bone substitutes are used for defect healing. Different growth factor loading has been investigated enhanced regeneration. The platelet is a cellular component of blood which naturally contains pool necessary factors that mediate initiation, continuation, and completion mechanism In this work, we have the encapsulation immobilization platelet-rich plasma (PRP) with natural polymers like hyaluronic acid (HA) gelatin (Gel) them in biphasic (BCP)...

TAC chemotherapy is a standard adjuvant treatment for early-stage breast cancer, with G-CSF recommended preventing febrile neutropenia (FN). This study investigates the optimal initiation timing daily filgrastim to prevent FN in patients undergoing chemotherapy, subject not fully explored existing guidelines. Sixty cancer receiving were randomly assigned start either on Day 2 (Day group, n = 30) or 5 30). The primary outcome was incidence of FN. Secondary outcomes included duration and...

Purpose: Recently, the neutrophil-to-lymphocyte ratio (NLR), an inflammatory response marker, has been reported to be associated with prognosis in patients various type of cancer.However, there have no studies until now that explored prognostic role combined detection NLR and CEA synchronous liver-limited colorectal metastases (sCRLM).Methods: Eighty-three who histologically diagnosed as sCRLM were selected.Their laboratory clinical data collected retrospectively.Using receiver operating...

Purpose Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis several malignancies. Hence, we estimated the increased expression relative Ang-1 patients colorectal cancer our finding prognosis order investigate relationships between expressions Ang-1/Ang-2/Tie-2 receptor clinical parameters or overall survival such patients....

Astrocyte elevated gene-1 (AEG-1) plays important roles in tumorigenesis such as proliferation, invasion, metastasis, angiogenesis, and chemoresistance. We examined the expression of AEG-1 patients with hepatocellular carcinoma (HCC).Eighty-five samples were collected from HCC who underwent surgery histopathologically confirmed to have HCC. Two independent pathologists, experienced evaluating immunohistochemistry blinded clinical outcomes patients, reviewed all samples. They determined...

Cystic lymphangiomas of the adrenal gland are rare.A 79-year-old female presented in emergency room with epigastric discomfort, and an immovable mass was palpated her abdomen upon physical examination.Imaging studies revealed a large cystic lesion pancreatic tail.The radiologic impression ruled out possibility mucinous neoplasm, or pseudocyst pancreas.The operative findings demonstrated that originated left gland.A laparoscopic excision performed, immunohistochemistry confirmed this...

Internal biliary fistula (IBF) is occurred spontaneously due to the disease in most cases. Bilioenteric, biliobiliary, bronchobiliary, and vasculobiliary type of IBF have been reported literature. We herein describe our experience with an incidental cholecystojejunal fistula, a very rare bilioenteric laparoscopic cholecystectomy. A 61-year-old woman several years' history intermittent right upper abdominal pain was admitted Soonchunhyang University Cheonan Hospital. Abdominal CT scan showed...

Anastomotic leakage due to post-surgical suture line disruption is one of the crucial factors affecting patient's survival and quality life. To resolve poor healing surgical anastomosis protect sites leakage, fibrous membrane sealing patch was developed using a synthetic polymer (polycaprolactone (PCL)) biopolymer (gelatin). Electrospinning used develop architecture membranes fabricated in different ratios (15% (w/v) PCL: 15% gelatin mixing ratio 1:1, 1:2, 1:3 1:4). Experimental findings...

Post-operative pancreatic leakage is a severe surgical complication that can cause internal bleeding, infections, multiple organ damage, and even death. To prevent enhance the protection of suture lining tissue regeneration, dual-layer nanofibrous membrane composed synthetic polymer polycaprolactone (PCL) biopolymer gelatin was developed. The fabrication this (PGI-PGO) achieved through electrospinning technique, with inner layer (PGI) containing 2% PCL (w/v) 10% (w/v), outer (PGO) in mixing...

A variety of synthetic materials are currently in use as bone substitutes, among them a new calcium phosphate-based multichannel, cylindrical, granular substitute that is showing satisfactory biocompatibility and osteoconductivity clinical applications. These cylindrical granules differ their mechanical morphological characteristics such size, diameter, surface area, pore porosity. The aim this study to investigate whether the sizes these resultant inter-granular spaces formed by filling...

Hepatocellular carcinoma (HCC) is one of the most common malignancies in world, with high frequency rates Asia. Many patients have unresectable disease at time diagnosis, and early detection surgical resection best hope for survival. But, if HCC presenting as an extrahepatic mass, diagnosis difficult. Herein, we report a case primary masquerading pelvic mass. A 74-year-old woman was admitted to our hospital due palpable mass lower abdomen. CT scan detected approximately 15.0×13.4×11.4...

Alimentary tract duplications are uncommon congenital anomalies that usually present during the first decade of life. Complete duplication colon in adults is very rare and difficult to diagnose preoperatively. We report a case 40-year-old female with complete tubular which was initially misdiagnosed as salpingeal abscess due colovaginal fistula.

Recently, microRNA (miRNA) has been evaluated to provide a new diagnostic and therapeutic modality hepatocellular carcinoma (HCC) other tumors. They are small non-coding RNA molecules that function as transcriptional post-transcriptional regulators of gene expression by silencing target genes. The aim this study was evaluate the clinical significance microRNA-18a, 221 (miR-18a, miR-221) in HCC formalin-fixed paraffin-embedded (FFPE) tissue.miR-18a miR-221 expressions were assessed reverse...

Purpose: This study set out to identify the association between intraperitoneal CO 2 concentrations and postoperative pain by dividing participants into a control group experimental groups receiving irrigation (1 L L), directly measuring their with gas detector.Methods: A total of 101 patients, American Society Anesthesiologists physical status classification I II patients aged 18-65 years were enrolled in study.Group 1 did not receive normal saline, while 3 admin istered respectively, after...

Laparoscopic cholecystectomy (LC) is one of the most commonly performed surgeries in world today. However, there no consensus regarding whether LC can be patients with acute cholecystitis while on antithrombotic therapy. The objective our study was to describe postoperative outcomes who underwent emergent without interruption therapy.We a retrospective review for therapy from 2010 2015 at Soonchunhyang Universtiy Cheonan Hospital. Patients were divided into 2 groups as and elective LC.A...

Primary malignant peripheral nerve sheath tumor (MPNST) in a young female patient, not associated with neurofibromatosis type-I is extremely rare the liver. A 33-year-old was admitted right flank pain for weak. The CT scan showed 12.5-cm-sized mass located at hepatic lobe. At laparotomy, about 20.0-cm-sized on lobe attachment to diaphragmatic pleura. Right and adherent part of pleura were resected. On histology immunohistochemistry, it diagnosed MPNST. Adjuvant radiotherapy adjuvant...

Spontaneous rupture of PLA (pyogenic liver abscess) is an extremely rare and life-threatening event. Ruptured very difficult to distinguish from malignant HCC (hepatocellular cancer) or cholangiocarcinoma on CT (computed tomography) scan.We describe the case a 71-year-old man with fever, right upper abdominal pain, nausea intermittent vomiting, general fatigue. He had no medical surgical history.CT scan showed hypodense mass in hepatic lobe MRI (magnetic resonance imaging) revealed...

Backgrounds/Aims: Systematic investigations into the prognostic impact of longitudinal tumor location in gallbladder cancer (GBC) remain insufficient.To address limitations our pilot study, we conducted a multicenter investigation to clarify on oncological outcomes GBC.Methods: A retrospective study was 372 patients undergoing radical resections for GBC from January 2010 December 2019 across seven hospitals that belong Daejeon-Chungcheong branch Korean Association Hepato-Biliary-Pancreatic...

Immune checkpoint inhibitors (ICIs) have been shown significant oncological improvements in several cancers. However, ICIs are still their infancy hepatocellular carcinoma (HCC). Programmed cell death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), and epithelial-mesenchymal transition (EMT) known as prognostic factors HCC. Therefore, we focused on identifying the molecular mechanisms between each marker to evaluate a predictive role.Formalin-fixed paraffin-embedded samples were...

The perineal defect in female genitalia results from multiple etiologies, including obstetric injury, sexual assaults, and trauma.Untreated defects may lead to significant physical, functional, esthetic complaints.Numerous reconstruction methods are used for a defect, but various complications, such as fecal impaction, incontinence, wound disruption, introduced.We report case of 40-yr-old woman with cloaca-like who was treated reconstructive surgery the recovered good anatomical functional outcome.