A5101794541- Connective Tissue Growth Factor Research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Effects and risks of endocrine disrupting chemicals
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Animal testing and alternatives
- Acute Myeloid Leukemia Research
- Caveolin-1 and cellular processes
- Thyroid Cancer Diagnosis and Treatment
- Kruppel-like factors research
- Biomarkers in Disease Mechanisms
- Macrophage Migration Inhibitory Factor
- Lipid metabolism and disorders
Hanyang University
2017-2025
Samsung Medical Center
2016-2024
Sungkyunkwan University
2016-2024
Stanford University
2024
Yeungnam University Medical Center
2023
Korea Institute of Radiological and Medical Sciences
2019
Soonchunhyang University
2012-2018
Life University
2017
Korea University
2014
Elevated glucose levels in cancer cells can be attributed to increased of transporter (GLUT) proteins. Glut1 expression is human malignant cells. To investigate alternative roles breast cancer, we silenced triple-negative breast-cancer cell lines using a short hairpin RNA (shRNA) system. silencing was verified by Western blotting and qRT-PCR. Knockdown resulted decreased proliferation, uptake, migration, invasion through modulation the EGFR/ MAPK signaling pathway integrin β1/Src/FAK...
Multiple cancers, including colorectal cancer (CRC), are more frequent and often aggressive in individuals with obesity. Here, we showed that macrophages accumulated within tumors of patients obesity CRC obese mice they promoted accelerated tumor growth. These changes were initiated by oleic acid accumulation subsequent cell–derived production driven macrophage signaling through the acid-sensing receptor GPR65. We found a similar role for GPR65 hepatocellular carcinoma (HCC) mice. Tumors or...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer. TNBC patients typically exhibit unfavorable outcomes due to its rapid growth and metastatic potential. Here, we found overexpression CCN3 in patients. We identified that knockdown diminished stem cell formation, metastasis, tumor vitro vivo. Mechanistically, ablation reduced activity EGFR/MAPK pathway. Transcriptome profiling revealed induces glycoprotein nonmetastatic melanoma protein B (GPNMB)...
Nidogen-1 (NID1) is a secreted glycoprotein widely distributed in basement membranes. NID1 interacts with extracellular matrix proteins such as collagen and laminin has been implicated the progression of various cancers. However, study on role breast cancer scarce inconsistent. In this work, we found that expression significantly lower tissue than normal tissue. addition, correlated negatively poor prognosis for patients. Based those findings, speculated might act suppressor cancer. To...
// KeeSoo Nam 1 , Seog-ho Son Sunhwa Oh Donghwan Jeon Hyungjoo Kim Dong-Young Noh 2 Sangmin 3 Incheol Shin 1, 4 Department of Life Science, Hanyang University, Seoul, 133-791, Korea Cancer Research Institute, Seoul National University College Medicine, 110-744, Surgery, Samsung Medical Center, 135-710, Natural Science Correspondence to: Shin, email: incheol@hanyang.ac.kr Keywords: galectin-1, integrin β1, STAT3, survivin, drug resistance Received: November 25,...
Other SectionsABSTRACTINTRODUCTIONNORMAL BIOLOGICAL FUNCTIONS OF THE CCN PROTEINSCCN PROTEIN IN TUMORIGENESISCONCLUSIONACKNOWLEDGEMENTSCONFLICTS INTERESTFIGURETABLEREFERENCES
Colorectal cancer is one of the most common cancers and fourth leading cause death in Korea. Mortality colorectal strongly associated with metastatic spread disease. As such, it important to find characterize signaling pathways involved colon metastasis. We investigated functional importance RhoA using human cell lines as well 150 patient-derived samples remains unclear whether functions either an oncogene or a tumor suppressor cancer. was highly expressed lines. Although proliferation only...
// Ita Novita Sari 1, * , Ying-Gui Yang Lan Thi Hanh Phi 1 Hyungjoo Kim 2 Moo Jun Baek 3 Dongjun Jeong Hyog Young Kwon Soonchunhyang Institute of Medi-bio Science (SIMS), University, Republic Korea Medical Research Institute, College Medicine, Department Surgery, Pathology, These authors contributed equally to this work Correspondence to: Kwon, email: hykwon@sch.ac.kr Jeong, juny1024@sch.ac.kr Keywords: IFITM1, colorectal cancer, prognosis, metastasis Received: June 06, 2016 Accepted:...
Abstract Background Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function an oncogene or tumour suppressor, depending on origin cancer. Only few studies have reported expression colorectal In this study, we assessed 251 cancers with clinical follow up. Methods We examined 6 cancer cell lines (HT29, Colo205, Lovo, HCT116, SW480, SW620) 20 sets paired...
ABSTRACT About 70% of breast cancers overexpress estrogen receptor α (ERα, encoded by ESR1). Tamoxifen, a competitive inhibitor that binds to ER, has been widely used as treatment for ER-positive cancer. However, 20–30% cancer is resistant tamoxifen treatment. The mechanisms underlying resistance remain elusive. We found Yes-associated protein (YAP; also known YAP1), connective tissue growth factor (CTGF; CCN2) and cysteine-rich angiogenic inducer 61 (Cyr61; CCN1) are overexpressed, while...
Abstract Cysteine-rich angiogenic inducer 61 (CYR61) is a protein from the CCN family of matricellular proteins that play diverse regulatory roles in extracellular matrix. CYR61 involved cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence. Here, we show induces chemoresistance triple-negative breast cancer (TNBC). We observed overexpressed TNBC patients, expression correlates negatively with survival patients who receive chemotherapy. knockdown reduced sphere...
Basal-like breast cancer (BLBC) has a clinically aggressive nature. It is prevalent in young women and known to often relapse rapidly. To date, the molecular mechanisms regarding aggressiveness of BLBC have not been fully understood. In present study, involving EGFR and/or HER2 expression interactions between tumor tumor-associated macrophages (TAMs) were explored. The prognosis patients who underwent surgery at Samsung Medical Center was analyzed. found that co-expression associated with...
Papillary thyroid carcinoma (PTC) of the is most common endocrine malignancy. High prevalence an activating point mutation BRAF gene, BRAF(V600E), has been reported in PTC. We assessed efficiency peptide nucleic acid clamp real-time polymerase chain reaction (PNAcqPCR) for detection BRAF(V600E) PTC comparison with direct sequencing (DS).A total 265 lesions including 200 PTCs, 5 follicular carcinomas, 60 benign and 10 normal tissues were tested by PNAcqPCR DS.The sensitivity accuracy method...
This study aimed to evaluate the prognostic impact of age at diagnosis, and pretreatment hematologic markers, including lymphocyte percentage neutrophil-to-lymphocyte ratio (NLR), in patients with locally advanced cervical cancer (LACC) treated definitive radiotherapy (RT).A total 392 LACC (stage IIb IVa) cisplatin-based concurrent chemoradiotherapy or RT alone between 2001 2012 were retrospectively enrolled. Clinical data complete blood counts extracted from electronic medical records...
Astrocyte elevated gene-1 (AEG-1) plays important roles in tumorigenesis such as proliferation, invasion, metastasis, angiogenesis, and chemoresistance. We examined the expression of AEG-1 patients with hepatocellular carcinoma (HCC).Eighty-five samples were collected from HCC who underwent surgery histopathologically confirmed to have HCC. Two independent pathologists, experienced evaluating immunohistochemistry blinded clinical outcomes patients, reviewed all samples. They determined...