A5050866789- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Orthopedic Infections and Treatments
- Ginseng Biological Effects and Applications
- Electrospun Nanofibers in Biomedical Applications
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Diabetic Foot Ulcer Assessment and Management
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Hip disorders and treatments
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Hematological disorders and diagnostics
- Caveolin-1 and cellular processes
- Advanced Breast Cancer Therapies
- Skin and Cellular Biology Research
- Nitric Oxide and Endothelin Effects
- Circular RNAs in diseases
- FOXO transcription factor regulation
The University of Texas MD Anderson Cancer Center
2020-2024
The University of Texas Health Science Center at Houston
2020-2022
Soonchunhyang University
2016-2019
Vietnam National University Ho Chi Minh City
2014-2017
Ho Chi Minh City University of Science
2015-2017
Inflammatory breast cancer (IBC), the most aggressive subtype, is driven by an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have limited efficacy. In a clinical trial (NCT01036087), anti-EGFR antibody combined with neoadjuvant chemotherapy produced highest pathological complete response rate ever reported in patients having triple-negative receptor status. We determined molecular and immunological mechanisms behind this superior outcome. Using novel humanized...
// Ita Novita Sari 1, * , Ying-Gui Yang Lan Thi Hanh Phi 1 Hyungjoo Kim 2 Moo Jun Baek 3 Dongjun Jeong Hyog Young Kwon Soonchunhyang Institute of Medi-bio Science (SIMS), University, Republic Korea Medical Research Institute, College Medicine, Department Surgery, Pathology, These authors contributed equally to this work Correspondence to: Kwon, email: hykwon@sch.ac.kr Jeong, juny1024@sch.ac.kr Keywords: IFITM1, colorectal cancer, prognosis, metastasis Received: June 06, 2016 Accepted:...
ABSTRACT Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside on metastasis colorectal cancer (CRC) remains unknown. Here, we found that decreased colony‐forming ability, migration, invasion, wound‐healing abilities CRC cells, although it did not affect cell proliferation. In addition, using an inverse‐docking assay, bound epidermal growth factor receptor (EGFR) with high binding affinity, inducing...
Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes, facilitating metastasis, a leading cause of cancer-related mortality. Hybrid epithelial-mesenchymal (E/M) cells, retaining both traits, exhibit heightened metastatic potential stemness. The intermediate filament, vimentin, is upregulated during EMT, enhancing the resilience invasiveness carcinoma cells. phosphorylation vimentin critical to its structure function. Here, we identify...
Ginsenoside Rb2, a saponin from Panax ginseng, has been shown to have many functions. However, the effect of ginsenoside Rb2 on metastasis colorectal cancer (CRC) remains unknown. CRC cell lines HT29 and SW620 were used determine effects colony-forming, migration, invasion, wound-healing abilities cells in vitro. Further, was given intraperitoneally at 5 mg/kg mouse body weight check its vivo. decreased colony-forming ability, wound healing vitro, although it did not affect proliferation. As...
Introductions: Joint replacements have considerably improved the quality of life patients with damaged joints. Over past 30 years, there has been much effort and investigations in ways to repair damages joints, including knee hip Materials for joint production also developed. Many improvements made replacement materials increase their biocompatibility longevity. This study is aimed at evaluating vitro vivo Ti-6Al-4V titanium alloy UHMWPE polymer used total replacements. Methods: were...
Cancer stem cells (CSCs) have been proposed as central drivers of cancer relapse in many cancers. In the present study, we investigated inhibitory effect 20(R)-Ginsenoside Rg3 (Rg3R), a major active component ginseng saponin, on CSC-like and Epithelial-Mesenchymal Transition (EMT) colorectal (CRC).The effects ginsenoside Rg3R colony-forming, migration, invasion, wound-healing abilities CRC were determined HT29 SW620 cell lines vitro. Further, was given intraperitoneally at 5mg/kg mouse body...
Although an immunosuppressive tumor microenvironment (TME) is key for progression, the molecular characteristics associated with TME remain unknown in triple-negative breast cancer (TNBC). Our previous functional proteomic study of TNBC tumors identified that C-JUN N-terminal kinase (JNK) pathway-related molecules were enriched a cluster inflammatory pathway. However, role JNK pathway still unclear.
Emerging data indicate that interferon-induced transmembrane protein 1 (IFITM1) plays an important role in many cancers. However, it remains unclear whether IFITM1 is functionally indispensable nonsmall cell lung cancer (NSCLC). Here, using NSCLC lines and patient-derived samples, we show essentially required for the progression of vitro vivo. Specifically, depletion resulted a significant reduction sphere formation, migration, invasion cells vitro; these events were inversely correlated...
Introduction: Bone marrow derived MSCs (BM-MSCs) and adipose (AD-MSCs) are among the types of stem cells most commonly studied. Our study aims to compare therapeutic efficacy allograft AD-MSCs versus BM-MSCs in a mouse model hindlimb ischemia. Methods: were isolated from belly fat femur bone marrow. They used treat mice with acute Treatment was compared 4 groups: injected BM-MSCs, AD-MSCs, non-treated phosphate buffered saline. Mice groups evaluated for following: necrosis grade leg, leg...
Introduction: Osteonecrosis of the femoral head is caused by various factors, including prolonged use steroid drugs, alcohol, vascular injuries and hemoglobinopathies. This study aims to develop a mouse model for glucocorticoid-induced avascular necrosis (AVN) head. Methods: Adult mice were randomly divided into two groups: experimental control. Group A (the group) was given (via intramuscular injection) 10 mg/kg lipopolysaccharide (LPS) 30 methylprednisolone (MPS). Each additionally...
Mesenchymal stem cells (MSCs) transplantation for the treatment of acute hindlimb ischemia is recently attracting attention many scientists. Identifying role donor in host a crucial factor improving efficiency treatment. This study evaluated injury repair xenogeneic adipose-derived cell (ADSC) mouse model. Human ADSCs were transplanted into limb ischemic mouse. The survival rate grafted and expression human VEGF-R2 CD31 positive assessed In addition, morphological functional recovery was...
Acute lower limb ischemia is a common peripheral artery disease whose treatment presents many difficulties. Stem cell transplantation considered novel and promising method of treating this disease. Umbili- cal cord blood (UCB) rich in stem cells, including hematopoietic cells (HSCs), mesenchymal (MSCs) endothelial progenitor (EPCs). However, historically, banked umbilical has been used mainly to treat blood-related diseases. Therefore, study compared the efficacy blood- derived mononuclear...
The adipose tissue contains a large numbers of stem cells; adipose-derived cells (ADSCs) can be em- ployed in regenerative medicine. This study was aimed at isolating ADSCs and evaluating the safety mouse models. Stromal vascular fraction (SVF) collected from using collagenase. were then isolated SVFs by vitro culture. stemness evaluated based on their self-renewal potential, po- tential to differentiate into osteoblasts, adipocytes, expression specific markers. Finally, tumor forma- tion...