A5056699162- Cancer Cells and Metastasis
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
- Photodynamic Therapy Research Studies
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Skin and Cellular Biology Research
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
California State University, Northridge
2019-2024
Brown University
2023-2024
Baylor University
2023
Epithelial-mesenchymal transition (EMT) is often linked with carcinogenesis. However, EMT also important for embryo development and only reactivates in cancer. Connecting how occurs during embryonic cancer could help us further understand the root mechanisms of diseases. There are key regulatory elements that contribute to induction maintenance stem cell properties embryogenesis, tissue regeneration, Here, we explore implications different stages embryogenesis development. We especially...
Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes, facilitating metastasis, a leading cause of cancer-related mortality. Hybrid epithelial-mesenchymal (E/M) cells, retaining both traits, exhibit heightened metastatic potential stemness. The intermediate filament, vimentin, is upregulated during EMT, enhancing the resilience invasiveness carcinoma cells. phosphorylation vimentin critical to its structure function. Here, we identify...
Extracellular matrix (ECM) protein expression/deposition within and stiffening of the breast cancer microenvironment facilitates disease progression correlates with poor patient survival. However, mechanisms by which ECM components control tumorigenic behaviors responses to therapeutic intervention remain poorly understood. Fibronectin (FN) is a major controlling multiple processes. In this regard, we previously reported that DHPS-dependent hypusination eIF5A1/2 necessary for...
Abstract Extracellular matrix (ECM) protein expression/deposition within and stiffening of the breast cancer (BC) microenvironment, facilitates disease progression correlates with poor patient survival. However, mechanisms by which ECM components control tumorigenic behaviors responses to therapeutic intervention remain poorly understood. Fibronectin (FN) is a major controlling multiple processes related metastasis. In this regard, we previously reported that DHPS-dependent hypusination...
Abstract One of the main drivers for drastic reduction in survival rates caused by metastatic breast cancer is attributed to Epithelial-to-Mesenchymal Transition (EMT). During embryonic development and wound healing, EMT plays a vital role during pathogenesis, cells reactivate this program gain plasticity, migration, invasion promoting metastasis. In addition, also crucial generating subpopulation highly resilient tumor known as stem (CSCs). Moreover, following conventional treatment,...
Abstract Breast cancer ranks first among female cancer-related deaths in 2021, and fewer than 20% of patients survive five years after metastasis. Triple negative breast (TNBC or basal) is highly aggressive particularly difficult to treat due the lack therapeutic target receptors. Notably, elevated fibronectin expression within microenvironment TNBC an indicator advanced disease stage. In this regard, we previously reported that two-step, hypusination reaction activates eukaryotic initiation...