The interaction of programmed death receptor 1 (PD-1) and its ligand, ligand (PD-L1), negatively regulates immune responses. This study aimed to clarify PD-L1 expression levels in breast cancer through immunohistochemistry (IHC) evaluate associations between these findings clinicopathologic variables, including prognosis. was analyzed using IHC on tissue microarrays 465 invasive carcinomas. High demonstrated 63 tumors (13.5%). significantly associated with high histologic grade (p<0.001),...

TAC chemotherapy is a standard adjuvant treatment for early-stage breast cancer, with G-CSF recommended preventing febrile neutropenia (FN). This study investigates the optimal initiation timing daily filgrastim to prevent FN in patients undergoing chemotherapy, subject not fully explored existing guidelines. Sixty cancer receiving were randomly assigned start either on Day 2 (Day group, n = 30) or 5 30). The primary outcome was incidence of FN. Secondary outcomes included duration and...

Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose this study was to evaluate nuclear expression ARID1A cancers by immunohistochemistry (IHC) and correlate findings clinicopathologic variables prognostic significance. IHC performed on tissue microarrays 476 cases Associations between characteristics molecular subtype were retrospectively analyzed. Low found 339...

The enhancer of zeste homologue 2 (EZH2) is a catalytic subunit the polycomb repressive complex 2, highly conserved histone methyltransferase. EZH2 overexpression has been implicated in various malignancies, including breast cancer, where associated with poor outcomes. This study aims to clarify nuclear expression levels cancers using immunohistochemistry (IHC) and correlate these findings clinicopathologic variables, prognostic significance. IHC was performed on tissue microarrays 432...

Breast cancer survivors have slightly increased the risk of second primary cancers. Breast, colon, uterine, and ovarian cancers are common secondary in breast survivors. In this study, we assessed development Korea.Medical records patients with 3 tertiary medical institutions were reviewed retrospectively. We evaluated malignancy diagnosed at least 2 months after diagnosis. Based on International Classification Disease-9 codes malignancies, person-year adjustment. The standardized incidence...

Abstract Background The objective of this study was to investigate the prognostic value 2-Deoxy-2-[ 18 F]fluoro-D-glucose ([ F]FDG) uptake bone marrow (BM) and metabolic parameters primary tumor on positron emission tomography/computed tomography (PET/CT) for predicting distant recurrence in patients with breast cancer. Methods Pretreatment [ F]FDG PET/CT images 345 cancer were retrospectively evaluated. Maximum standardized value, volume, total lesion glycolysis (TLG) marrow-to-liver ratio...

Background: Although international guidelines recommend bone screening for premenopausal breast cancer patients taking adjuvant tamoxifen, the effects of tamoxifen on osteoporosis and related risks remain controversial. The objective this study was to investigate incidence risk factors osteoporotic fractures in younger patients. Methods: A nationwide retrospective cohort conducted using South Korea Health Insurance Review Assessment Service claims data. rates fracture were calculated as...

To compare the outcomes between laparoscopic total extraperitoneal (TEP) repair and prolene hernia system (PHS) for inguinal hernia.A retrospective analysis of 237 patients scheduled TEP or PHS groin from 2005 to 2009 was performed.The mean age 52.3 years in group 55.7 group. Of 119 cases, 98 were indirect hernia, 15 direct type, 5 femoral 1 complex hernia; 118 100 indirect, 18 type. All performed under general anesthesia 64% spinal epidural anesthesia. Preoperatively, 10 cases recurrent...

The purpose of this study was to evaluate the prognostic significance computed tomography (CT)-attenuation tumor-adjacent breast adipose tissue for predicting recurrence-free survival (RFS) in patients with cancer. We retrospectively enrolled 287 cancer who underwent pretreatment 18F-fluorodeoxyglucose (FDG) positron emission (PET)/CT. From non-contrast-enhanced CT images PET/CT, CT-attenuation values (TAT HU) and contralateral (CAT were measured. Difference (HU difference) percent...

PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated expression gastric cancer explored the relationships between level clinicopathological features as well survival patients.We examined tissue microarray 178 adenocarcinomas by immunohisto-chemistry reviewed patients' medical records.In our study, 112 patients displayed positive expression. Overexpression was correlated with low grade differentiation (P=0.001),...

We investigated whether textural parameters of peritumoral breast adipose tissue (AT) based on F-18 fluorodeoxyglucose (FDG) PET/CT could predict axillary lymph node metastasis in patients with cancer. A total 326 cancer preoperative FDG were retrospectively enrolled. images visually assessed and the maximum uptake nodes (LN SUVmax) was measured. From AT, 38 features PET imaging extracted. The diagnostic ability visual analysis, LN SUVmax, AT for predicting using area under receiver...

Purpose: Primary prophylaxis with granulocyte colony-stimulating factor can effectively prevent febrile neutropenia (FN) during breast cancer treatment.The aims of this study were to evaluate the incidence FN and ANC profile in patients under going chemotherapy pegfilgrastim primary prophylaxis.Methods: Patients receiving 6 cycles adjuvant docetaxel, doxorubicin, cyclophosphamide (TAC) included study.Pegfilgrastim was administered analgesics 24 hours after treatment.Laboratory tests...

The aim of this study was to predict the success 131I ablation using preablative 99mTc pertechnetate salivary scintigraphy and a postablative dual scan in differentiated thyroid cancer (DTC).A total 168 DTC patients who underwent with (early delayed) were enrolled. For scintigraphy, remnant uptake visually assessed. scan, background ratios (TBRs) on early delayed scans measured percentage change TBR (TBRΔ) calculated.Thyroid seen 69 (41%) 162 (96%) scan. rate higher negative (86%) than...

This study aimed to evaluate the association between abdominal-to-gluteofemoral adipose tissue (AT) distribution and recurrence-free survival (RFS) in breast cancer patients. Staging F-18 fluorodexoyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images of 336 women with were retrospectively analyzed. From CT images, volume CT-attenuation visceral (VAT), abdominal subcutaneous (SAT), gluteofemoral AT measured ratio abdomen-to-gluteofemoral (AG ratio) was calculated....

Transducin-like enhancer of split 1 (TLE1) is a member the TLE family transcriptional co-repressors that control transcription wide range genes. We investigated prognostic significance TLE1 protein expression in breast cancers by using immunohistochemistry and explored relationship with clinicopathological parameters. Immunohistochemistry was performed on 456 cases cancer tiled tissue microarrays. The between normal specimens ductal carcinoma situ (DCIS) also analyzed. highly expressed 57...

Interdigitating dendritic cell sarcoma (IDCS) is a very rare disease around the world and its prognosis known to be aggressive. This reports case diagnosed as IDCS of axillary region treated in Soonchunhyang University Hospital. A 57-year-old female visited Hospital with left mass. The mass was hard fixed. Computed tomography observed 7 cm lymph node at axilla, core biopsy suspected sarcoma. In another study, there no specific finding except lesion. Left dissection (level I, II) conducted...

A 53-year-old woman was diagnosed with gastrointestinal stromal tumor (GIST) of the stomach. Computed tomography (CT) revealed a huge mass (12 cm in diameter), likely to invade pancreas and spleen. In operation field, an unresectable state. The patient then started on imatinib therapy for 4 months. On follow-up imaging studies, almost disappeared. We performed total gastrectomy splenectomy upon which two small-sized residual tumors were found microscopy. this paper, we describe case...

High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought determine whether long-term survivors had an elevated risk low bone density compared the general population.Long-term who treated for more than 5 years were selected study. Data obtained from medical records using a questionnaire Korea National Health Nutrition Examination Survey (KNHANES). An...

Whole-body bone scans and whole body (18)F-fluorodeoxyglucose positron emission tomographic/computed tomographic are sensitive for detecting metastasis in patients with breast cancer. However, it is often difficult to discriminate between other nonmalignant lesions. Polyostotic fibrous dysplasia a rare disorder characterized by the osteoid medullary cavity filling tissue causing bony expansion. We report case of 42-year-old female patient ductal carcinoma situ, which appeared have multiple...