A5077104820- Telomeres, Telomerase, and Senescence
- Drug Transport and Resistance Mechanisms
- HER2/EGFR in Cancer Research
- Pharmacogenetics and Drug Metabolism
- Nuclear Structure and Function
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Alcohol Consumption and Health Effects
- Computational Drug Discovery Methods
- Gene expression and cancer classification
- Monoclonal and Polyclonal Antibodies Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet and metabolism studies
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
- Drug-Induced Hepatotoxicity and Protection
- Aldose Reductase and Taurine
- Cancer Risks and Factors
- Ginkgo biloba and Cashew Applications
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
Konkuk University
2014-2025
Konkuk University Medical Center
2010-2024
Kumoh National Institute of Technology
2018-2024
University of Cambridge
2023
Korea University of Science and Technology
2022
Korea Research Institute of Bioscience and Biotechnology
2022
Soonchunhyang University
2008-2021
Daegu University
2019
Kangbuk Samsung Hospital
2015-2016
Sungkyunkwan University
2012-2016
This study aimed to explore the effects of age, education and gender on performance eight tests in Korean version CERAD neuropsychological assessment battery provide normative information elderly. The was administered 618 healthy volunteers aged from 60 90. People with serious neurological, medical psychiatric disorders, including dementia, were excluded. Multiple linear regression analyses performed assess relative contribution demographic factors score each cognitive test. Age, education,...
Background Recent studies have demonstrated that activation of autophagy increases the lifespan organisms from yeast to flies. In contrast extension effect in lower organisms, it has been reported overexpression unc-51-like kinase 3 (ULK3), mammalian homolog autophagy-specific gene 1 (ATG1), induces premature senescence human fibroblasts. Therefore, we assessed whether would genuinely induce cells. Methodology/Principal Findings Depletion ATG7, ATG12, or lysosomal-associated membrane protein...
To determine whether an Internet-based tailored education program is effective for disease-free cancer survivors with cancer-related fatigue (CRF).We randomly assigned patients who had completed primary treatment within the past 24 months in any of four Korean hospitals and reported moderate to severe at least 1 week participate a 12-week, Internet-based, individually CRF or receive routine care. We based on guidelines National Comprehensive Cancer Network (NCCN) incorporated transtheoretic...
Abstract Arachidonic acid (AA) mainly released from the cell membrane by phospholipase A 2 (PLA ) is converted to eicosanoids action of cyclooxygenase (COX) and lipoxygenase (LO). In order find specific inhibitors AA metabolism especially PLA COX‐2, 300 plant extracts were evaluated for their inhibitory activity on PGD production cytokine‐induced mouse bone marrow‐derived mast cells in vitro . From this screening procedure, methanol extract Salvia miltiorrhiza was found inhibit ethyl acetate...
// Sangjeong Ahn 1, 6, * , Soomin 2, Michael Van Vrancken Minju Lee 1 Sang Yun Ha Hyuk 3 Byung-Hoon Min Jun Haeng Jae J. Kim Sunkyu Choi 4 Sin-Ho Jung Gew 5 Jun-Ho Tae Sung Sohn Moon Bae Kyoung-Mee 2 Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School Medicine, Seoul, Korea Center for Companion Diagnostics, Innovative Cancer Medicine Institute, Biostatistics and Clinical Epidemiology Surgery, 6 Present address: Pathology, Pusan National...
Therapy-induced senescence, an irreversible growth arrest, in cancer cells is regarded as a novel functional target that may improve therapy. 20(S)-ginsenoside Rg3 [20(S)-Rg3], chemical component extracted from Panax ginseng, has recently emerged effective anticancer medicine with evident antitumor effects and no observed toxic adverse reactions. We report here chronic treatment 20(S)-Rg3 sub-lethal concentration induced senescence-like arrest human glioma cells. Glioma treated showed high...
Abstract Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even reversing aging. We found that nintedanib, tyrosine kinase inhibitor, selectively induced the death primary human dermal fibroblasts undergoing RS. Similar ABT263, well-known agent, nintedanib triggered intrinsic apoptosis in cells. Additionally, at concentration producing effect, arrested cell cycle nonsenescent cells G1 phase without...
ABSTRACT Toll‐like receptor 5 (TLR5) plays a critical role beyond its traditional function in innate immunity, significantly impacting metabolic regulation and liver health. Previously, we reported that TLR5 activation extends the healthspan lifespan of aging mice. This study demonstrates deficiency leads to pronounced abnormalities with age, primarily affecting functions rather than intestinal inflammation. Comprehensive RNA sequencing analysis revealed induces gene expression changes...
Oxidative stress is detrimental to life process and particularly responsible for aging age-related diseases. Thus, most organisms are well equipped with a spectrum of biological defense mechanisms against oxidative stress. The major efficient antioxidative mechanism the glutathione system, operating redox cycling utilization, which consists its peroxidase reductase. However, this system mainly effective hydrophilic oxidants, while lipophilic oxidants require another scavenging system. Since...
Intensive glucose control increases the all-cause mortality in type 2 diabetes mellitus (T2DM); however, underlying mechanisms remain unclear. We hypothesized that strict diet to achieve euglycemia damages major organs, increasing risk. To evaluate effects on organs when is obtained by control, we generated a model of end-stage T2DM 13-week-old Sprague-Dawley rats subtotal pancreatectomy, followed ad libitum feeding for 5 weeks. divided these into two groups and subsequent 6 weeks provided...
To date, there have been several experimental studies to assess tissue viability of transverse rectus abdominis myocutaneous (TRAM) flaps. Botulinum toxin A (BoTA) has gained popularity in many clinical fields, for a variety therapeutic and aesthetic purposes. In addition, reports regarding the positive effect BoTA on flap survival by various mechanisms. this study, we hypothesized that pretreatment with could augment TRAM flaps via increased hypoxia-inducible factor (HIF)1α/vascular...
Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, role BLVRA in aging process remains unclear. To study process, we compared stress responses young and senescent human diploid fibroblasts (HDFs) reactive oxygen species (ROS) inducer, hydrogen peroxide (H2O2). H2O2 markedly induced activity HDFs, but not HDFs. Additionally, depletion reduced H2O2-dependent induction heme oxygenase-1...
Summary Hyporesponsiveness to external signals, such as growth factors and apoptotic stimuli, is a cardinal feature of cellular senescence. We previously reported that an aging‐dependent marked reduction in nucleocytoplasmic trafficking ( NCT )‐related genes could be responsible for this phenomenon. In searching the mechanism, we identified transcription factor, S p1, common regulator genes, including various nucleoporins, importins, exportins, R GTP ase cycle‐related genes. Sp1 knockdown...
Breast cancer survivors have slightly increased the risk of second primary cancers. Breast, colon, uterine, and ovarian cancers are common secondary in breast survivors. In this study, we assessed development Korea.Medical records patients with 3 tertiary medical institutions were reviewed retrospectively. We evaluated malignancy diagnosed at least 2 months after diagnosis. Based on International Classification Disease-9 codes malignancies, person-year adjustment. The standardized incidence...
A photoresponsive organic complementary inverter was fabricated and its light sensing characteristics studied. An circuit by integrating p-channel pentacene n-channel copper hexadecafluorophthalocyanine (F16CuPc) thin-film transistors (OTFTs) with a polymeric gate dielectric. The F16CuPc OTFT showed typical n-type strong photoresponse under illumination. Whereas illumination, the relatively weak p-type characteristics. of electro-optical could be controlled incident intensity, bias, or both....