A5067962215- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Reconstructive Surgery and Microvascular Techniques
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Lymphatic System and Diseases
- Metastasis and carcinoma case studies
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Genomic variations and chromosomal abnormalities
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- AI in cancer detection
Seoul National University Bundang Hospital
2015-2024
Seoul National University
2007-2024
National University College
2024
New Generation University College
2007-2024
Seoul St. Mary's Hospital
2017
Korea Institute of Radiological and Medical Sciences
2010-2016
Inje University Busan Paik Hospital
2016
Seoul National University Hospital
2008
Korea Institute of Science and Technology
2002
Although radiotherapy resistance is associated with locoregional recurrence and distant metastasis in breast cancers, clinically relevant molecular markers critical signaling pathways of radioresistant cancer are yet to be defined. Herein, we show that HER2-STAT3-survivin regulation HER2-positive cancers. Depletion HER2 by siRNA sensitized cells irradiation decreasing STAT3 activity survivin, a target gene, expression cells. Furthermore, inhibition activation or depletion survivin also...
Abstract Background Following sentinel lymph node biopsy (SLNB), the axillary recurrence rate is very low although SLNB has a false-negative of 5–10%. In ACOSOG Z0011 trial, non-sentinel positive-lymph nodes were found in more than 20% dissection group; only group did not have higher rate. These findings raised questions about direct therapeutic effect SLNB. post-surgical complications including lymphedema. Considering advances imaging modalities and adjuvant therapies, role early breast...
We sought to determine the significance of Ki-67, one tumor cell proliferation markers, as a useful prognostic factor in early breast cancer. A total 1080 consecutive patients with stage I or II cancer that underwent surgery between 1998 and 2003 were enrolled. Patients categorized on basis 2007 St. Gallen consensus Adjuvant! Online. The expression Ki-67 was assayed by immunohistochemistry (cutoff value, 10%). Univariate analysis determined size, lymph node involvement, histologic grade,...
Abstract Background Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients postmenopausal breast cancer. Preclinical and clinical studies have the antidiabetic drug metformin anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed evaluate direct effect non-diabetic women estrogen-receptor (ER) positive Methods/Design Patients meeting inclusion criteria...
Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its activity not well understood. In present study, we investigated combined effects melatonin and arsenic trioxide (ATO) on cell death human breast cancer cells. enhanced ATO-induced apoptotic via changes protein levels Survivin, Bcl-2, Bax, thus affecting cytochrome c release from mitochondria to cytosol. Interestingly, found that induced by co-treatment with ATO was...
Although microinvasive carcinoma is distinct from ductal in situ (DCIS), the clinical significance of microinvasion DCIS remains elusive. The purpose this study to evaluate clinicopathological features and outcomes compared with pure DCIS. We assessed 613 cases that were consecutively resected 2003 2014 analyzed variables, expression standard biomarkers such as estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), p53, Ki-67, tumor recurrence. Among cases, 136...
The management of benign intraductal papilloma (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial. This study was performed to evaluate the rate upgrading malignancy or high-risk lesions after excision and identify factors associated with using a large series IDP cases atypia.
Background Recent studies suggest that US-guided directional vacuum-assisted removal (DVAR) is a satisfactory alternative to surgery for benign papilloma of the breast and recommend discretionary diagnostic US follow-up without intervention. Purpose To compare outcomes atypia diagnosed with core needle biopsy (CNB) in patients who underwent DVAR, intervention, or surgery. Materials Methods This retrospective review included consecutive CNB between January 2005 September 2015. Five hundred...
A girl (age, 12 years 11 months) consulted the pediatric endocrinology clinic because of a rapidly growing right breast mass over 13 cm observed during preceding 3 months. surgical excision was performed, and diagnosed as giant juvenile fibroadenoma. Giant fibroadenomas are rare, usually occurring between 10 18 age, characterized by massive rapid enlargement an encapsulated mass. The etiology is believed to be end-organ hypersensitivity normal levels estrogen. We report case fibroadenoma...
Abstract Background Human epidermal growth factor receptor 2 (HER2)-low status has recently gained attention because of the potential therapeutic benefits antibody–drug conjugates (ADCs) in breast cancer patients. We aimed to investigate concordance HER2 between core needle biopsy (CNB) and subsequent surgical resection specimens focusing on HER2-low status. Methods This retrospective study was conducted 1,387 patients with invasive whose evaluated both CNB specimens. The discordance rates...
To investigate the preoperative factors associated with upstage to invasive cancer in patients core needle biopsy (CNB) diagnosis of ductal carcinoma situ (DCIS) by ultrasound guidance alone.Between 2000 and 2007, 201 DCIS diagnosed at 11- or 14-gauge CNB alone were examined. Preoperative all analyzed correlate presence after definitive resection. The Pearson chi-square test stratified analysis Mantel-Haenszel chi-squire used assess association between cancer.Compared overall underestimation...
Breast cancer patients undergoing axillary lymph node dissection (ALND) are at risk of lymphedema (LE). Successful management LE relies on early diagnosis using sensitive modalities. In the current study, we explored effectiveness a surveillance program for (SLYM) compared to standard care. who underwent ALND in Seoul National University Bundang Hospital from January 2008 December 2015 were included this prospective study. The SLYM commenced May 2011. outcomes treated prior initiation with...
This study investigated whether hypofractionated adjuvant radiotherapy (RT) increased breast-related complication(s) compared to conventional fractionated RT in reconstructed breast cancer patients.We conducted a retrospective review including 349 patients who underwent immediate reconstruction following mastectomy or breast-conserving surgery (BCS) between 2009 and 2018 at two institutions. All were treated with via either regimen. We defined major complication as toxic event requiring...
Abstract We tried to establish models that predict systemic recurrence in breast cancer by selecting marker clones with DNA copy number alterations (CNAs) using an array comparative genomic hybridization (CGH). Array CGH containing 4,044 human bacterial artificial chromosome was used assess CNAs 62 primary tissues from 31 patients within 5 years after surgery and clinicopathologically well matched who had no evidence of disease for at least 5years. Fourteen significant (11 showing gain 3...