A5080844931- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Medical Imaging Techniques and Applications
- Cancer and Skin Lesions
- Pluripotent Stem Cells Research
- Vascular Malformations Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Digital Radiography and Breast Imaging
- Lymphoma Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Acupuncture Treatment Research Studies
- Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Lanthanide and Transition Metal Complexes
- Pain Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Oral and Maxillofacial Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
Gyeongsang National University Hospital
2013-2024
Gyeongsang National University
2011-2024
University of California, San Diego
2024
Gachon University
2011-2021
Gachon University Gil Medical Center
2012-2020
Korea National Institute of Health
2017-2019
Kyung Hee University
2012-2019
Seoul National University Bundang Hospital
2019
Chungbuk National University
2017-2018
Ewha Womans University
1999-2017
To examine the catabolic pathways mediated by Toll-like receptor (TLR) ligands in human osteoarthritic (OA) chondrocytes.The presence of TLRs OA and non-OA articular cartilage was analyzed immunohistochemistry. The regulation TLR messenger RNA (mRNA) interleukin-1 (IL-1) tumor necrosis factor alpha (TNFalpha) reverse transcription-polymerase chain reaction. For stimulation TLR-2 TLR-4, chondrocytes were treated with Staphylococcus aureus peptidoglycan lipopolysaccharides (LPS), respectively....
After spinal cord injury, the disruption of blood–spinal barrier by activation matrix metalloprotease is a critical event leading to infiltration blood cells, inflammatory responses and neuronal cell death, contributing permanent neurological disability. Recent evidence indicates that fluoxetine, an anti-depressant drug, shown have neuroprotective effects in ischaemic brain but precise mechanism underlying its protective largely unknown. Here, we show fluoxetine prevented via inhibition...
To investigate the effect of combined use ultrasonographic (US) elastography and color Doppler US on accuracy radiologists in distinguishing benign from malignant nonpalpable breast masses making decision for biopsy recommendations at B-mode US.This prospective study was conducted with institutional review board approval; written informed consent obtained. A cohort 367 biopsy-proved cases 319 women (age range, 22-78 years; mean age, 48.6 years) US, elastographic, images included. Five...
The disruption of blood-spinal cord barrier (BSCB) after spinal injury (SCI) elicits an intensive local inflammation by the infiltration blood cells such as neutrophils and macrophages, leading to cell death permanent neurological disability. SCI activates matrix metalloprotease-9 (MMP-9), which is known induce BSCB disruption. Here, we examined whether valproic acid (VPA), a histone deacetylase inhibitor, would attenuate inhibiting MMP-9 activity, improvement functional outcome SCI. After...
Both oxidative stress and endoplasmic reticulum (ER) are known to contribute secondary injury, ultimately leading cell death after spinal cord injury (SCI). Here, we showed that valproic acid (VPA) reduced of motor neurons by inhibiting cytochrome c release mediated ER SCI. After SCI, rats were immediately injected with VPA (300 mg/kg) subcutaneously further every 12 h for an indicated time period. Motor neuron at early SCI was significantly attenuated treatment. Superoxide anion (O2-)...
The corpus callosum (CC) is the largest white matter structure in brain, consisting of more than 200-250 million axons that provide a large connection mainly between homologous cerebral cortical areas mirror image sites. posterior end CC thickest part, which called splenium. Various diseases including congenital to acquired lesions anomalies, traumatic lesions, ischemic diseases, tumors, metabolic, toxic, degenerative, and demyelinating can involve splenium their clinical symptoms signs are...
To evaluate whether artificial intelligence (AI) for detecting breast cancer on mammography can improve the performance and time efficiency of radiologists reading mammograms.A commercial deep learning-based software was validated using external data collected from 200 patients, 100 each with without (40 benign lesions 60 lesions) one hospital. Ten readers, including five specialist (BSRs) general (GRs), assessed all images a seven-point scale to rate likelihood malignancy in two sessions,...
We screened active compounds from natural marine products able to increase PPARα/γ transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic (SHQA) Sargassum yezoense were identified as novel dual agonists. The binding affinity of SQA with PPARγ was higher than that the specific agonist troglitazone, leading an activation In parallel, treatment 3T3‐L1 cells SHQA led in adipocyte differentiation increased expression adipogenic marker genes such aP2, PPARγ, resistin, adiponectin,...
Purpose To investigate the value of combined use elastography and color Doppler ultrasonography (US) with B-mode US for evaluation screening US-detected breast masses in women dense breasts. Materials Methods This prospective, multicenter study included asymptomatic breasts who were referred between November 2013 December 2014. Eligible had a newly detected mass at conventional screening, which performed. The following outcome measures compared combination US, elastography, US: area under...
Background Recent studies suggest that US-guided directional vacuum-assisted removal (DVAR) is a satisfactory alternative to surgery for benign papilloma of the breast and recommend discretionary diagnostic US follow-up without intervention. Purpose To compare outcomes atypia diagnosed with core needle biopsy (CNB) in patients who underwent DVAR, intervention, or surgery. Materials Methods This retrospective review included consecutive CNB between January 2005 September 2015. Five hundred...
This study analyzed the color and power Doppler signals in solid breast masses assessed their value differentiating malignant from benign lesions.One hundred twenty-nine biopsy-proven (54 75 benign) were evaluated with and/or sonography using a 7-MHz linear-array transducer. We retrospectively location, shape, penetration of vascular masses. The location was categorized as central, peripheral, or both. shape linear, irregular, branching, single dot. A penetrating vessel defined continuous...
Background It has been reported that ultrasound (US)-elastography is helpful in differentiation of benign and malignant solid masses reducing biopsy procedures for the supplemental breast US addition to screening mammography. Furthermore, potential application US-elastography distinguishing cystic lesions which known be a major source results suggested. Purpose To describe aliasing artifact on mimic masses. Material Methods We retrospectively reviewed 13 showed blue-green-red pattern women...
The purpose of this study was to determine the roles sonography and sonographically guided fine-needle aspiration biopsy core-needle for initial axillary staging breast cancer.Of 220 patients with cancer who underwent preoperative or prechemotherapy staging, 52 cortical thickening a compressed hilum lymph nodes on were prospectively enrolled. Sonography biopsy/core-needle findings compared final pathologic results from sentinel node dissection.Forty-eight met criteria; we excluded 4 had...
A biofeedback-based balance training system can be used to provide the compromised sensory information subjects in order retrain their sensorimotor function. In this study, design and evaluation of low-cost, intuitive biofeedback developed at Gyeongsang National University is extended multimodal for by utilization visual haptic modalities. The consists a smartphone attached waist subject about tilt torso, personal computer running purpose built software process data means dedicated monitor...
Abstract Background: The excision of breast lesions using an ultrasound‐guided vacuum‐assisted biopsy device (VABD) is a widely used technique for the diagnosis and treatment disease, but results long‐term follow‐up after VABD benign tumours have not been reported. purpose this study was to evaluate complete VABD. Methods: This retrospective clinical study. Between January 2001 December 2004, patients who had undergone followed up by examination ultrasonography 2 years or more were included....
We compared the diagnostic performance of B-mode ultrasound, shear wave elastography (SWE), and combined ultrasound SWE in small breast lesions (≤ 2 cm), evaluated factors associated with false results.A total 428 cm) 415 consecutive patients between August 2013 February 2017 were included. The each set was using area under receiver operating characteristic curve (AUC) analysis. Histologic diagnosis used as reference standard. Multivariate logistic regression analyses identified results.Of...
Eccrine spiradenomas are rare, benign, cutaneous tumors that originate in the sweat glands. breast very rare and only a few cases have been reported. We report here on case of 47-year-old woman with superficial masses these had gradually increased size during follow-up. They were confirmed to be an eccrine spiradenoma pathologic examination. There reports about radiologic findings breast. This is first was characterized by multiple imaging modalities, including mammography, ultrasonography...
To compare digital breast tomosynthesis (DBT) and conventional full-field mammography (FFDM) in the detectability of cancers patients with dense tissue, to determine influencing factors detection using two techniques.Three blinded radiologists independently graded cancer 300 (288 women breasts) on DBT FFDM images, retrospectively. Hormone status, histologic grade, T stage, subtype were recorded identify affecting detectability. The Wilcoxon signed-rank test was used by FFDM. Fisher's exact...