A5042012932- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Intestinal Malrotation and Obstruction Disorders
- Advanced Breast Cancer Therapies
- Congenital gastrointestinal and neural anomalies
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Cancer Risks and Factors
- Plant Genetic and Mutation Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Gallbladder and Bile Duct Disorders
- bioluminescence and chemiluminescence research
- Head and Neck Surgical Oncology
- Multiple and Secondary Primary Cancers
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Anomalies and Fetal Surgery
Yonsei University
2014-2025
Wonju Severance Christian Hospital
2009-2022
Baylor College of Medicine
2018-2021
We retrospectively identified patients who were diagnosed with primary breast cancer and completed all phases of their treatment for at the Wonju Severance
Significance Mass spectrometry-based proteogenomics of patient-derived xenografts (PDXs) identified dihydropyrimidinase-like-3 (DPYSL3) as a multilevel (RNA/protein/phosphoprotein) expression outlier specific to claudin-low (CLOW) PDX. DPYSL3 has established functions in neural cell migration and axon outgrowth but is understudied breast cancer. Here, we demonstrate that loss promotes cell-cycle arrest, multinucleation, collapse the vimentin microfilament network associated with increased...
Bcl-2, a key regulator of cellular apoptosis, is typically linked to adverse prognosis in solid tumors due its inhibition apoptotic cell death and promotion proliferation, leading tumor progression. However, studies on Bcl-2 breast cancer have shown inconsistent results, with some indicating favorable outcomes. This study aims determine the subtype-specific role cancer. Female patients who completed primary treatment at Wonju Severance Hospital, Korea, from 2004 2018 were included....
Purpose: Accurate diagnosis and optimal management of acute appendicitis, despite being the most common surgical emergency encountered in departments, is often delayed pediatric patients due to nonspecific symptoms communication barriers, leading more complicated cases.The aim this study investigate diagnostic significance laboratory markers.Methods: A total 421 aged 15 younger underwent treatment for appendicitis.We conducted a retrospective analysis white blood cell (WBC), C-reactive...
Abstract Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ligand binding domain (LBD) is replaced by C-terminal sequences from many different partners. Here we functionally screened 15 fusions and 10 promoted estradiol-independent cell growth, motility, invasion, epithelial-to-mesenchymal transition, resistance to fulvestrant. RNA sequencing a...
Although fibroadenoma is one of the most common types benign breast tumor, genes specific to tumor have not been identified. Microarrays were used identify differentially expressed between and infiltrating ductal carcinoma. The comparative expression identified genes, RAS homolog enriched in brain ( RHEB ), was further explored using reverse transcriptase–polymerase chain reaction (RT‐PCR). Microarray analysis performed on tissue samples from five patients with fibroadenoma. In samples,...
Purpose: ROS1 is an oncogene, expressed primarily in glioblastomas of the brain that has been hypothesized to mediate effects early stage tumor progression.In addition, it was reported expression observed diverse cancer tissue or cell lines and associated with development several tumors.However, not studied breast date.Therefore, we investigated at protein gene level compare patterns verify association prognostic factors invasive ductal carcinoma (IDC) breast.Materials Methods: Tissue...
The effect of cyclin D1 overexpression on breast cancer outcomes and prognosis is controversial, even though amplification the gene, CCND1, has been shown to be associated with early relapse poor prognosis. In this study, we examined relationship between disease-specific survival (DSS). We also analyzed in patients who experienced recurrence.We retrospectively data from diagnosed ductal carcinoma April 2005 December 2010. clinicopathologic factors influence recurrence-free DSS.We identified...
Background: Histone deacetylase 1 (HDAC1) is associated with the expression and function of estrogen receptors proliferation tumor cells, has been considered a very important factor in breast progression prognosis.Several studies have reported an association between HDAC1 poorer prognosis cancers including cancer, few exceptions.However, because dearth on its significance for cancer not well defined.Therefore, we examined invasive ductal carcinoma (IDC), most common investigated potential...
Triple-negative breast cancer (TNBC) has been associated with worse prognosis, and biomarkers are needed to identify high-risk patients who may benefit from clinical trials or escalated treatment after completion of standard treatment. We aimed assess whether the post-treatment neutrophil-to-lymphocyte ratio (NLR) can reflect patient prognosis determine follow-up period that provide most feasible data.In this retrospective analysis involving TNBC, clinicopathological data, including those on...
Fibroadenoma (FA) and phyllodes tumor (PT) are stromal tumors of breast histologically similar. There no established differences in tumorigenesis oncogene expression among them. Ras homolog enriched brain (RHEB) plays an important role cell growth cell-cycle control, histone deacetylase 1 (HDAC1) is factor progression prognosis, WEE1 (WEE1) functions as a suppressor. No studies on the expressional these proteins FA PT have been reported to date.The FA, PT, normal was compared. We used 102...
Giant Meckel's diverticulum is a very rare lesion and its association with congenital diaphragmatic hernia has not been reported previously. We report case of newborn giant hernia. A large round atypical air-filled bowel segment was found by chest radiography preoperatively, located within the left hemithorax during surgery.
Abstract Background) More than half of the recurrent disease in breast cancer will happen more 5 years after initial diagnosis cancer, especially patients with ER positive disease. Higher proportions late recurrence lead to escalated treatment and/or or extended for high risk patients. However, it is unclear what characteristics make whom as This study aimed assess tumor vascularity a prognostic marker recurrence. Methods) Female estrogen receptor who were diagnosed between 2003 and 2018...
Abstract Introduction Korean Breast Cancer Society has organized the biennial Consensus Conference to find solutions clinical situations that cannot be answered by randomized trials or other definitive treatment research data. Unlike guidelines which are designed apply majority of patients with early advanced breast cancer encountered in daily practice, consensus meetings yield answers from clinicians’ perspectives and experiences. Therefore, this meeting aimed integrate patient preferences,...