Cervical cancer is the second leading cause of death among female patients with in world. High risk human papillomavirus has causal roles cervical initiation and progression by deregulating several cellular processes. However, HPV infection not sufficient for carcinoma development. Therefore, other genetic epigenetic factors may be involved this complex disease, identification which lead to better diagnosis treatment. Our aim was analyze expression microRNAs cases positive or negative E6/E7...

We report that daurinol, a novel arylnaphthalene lignan, is promising potential anticancer agent with adverse effects are less severe than those of etoposide, clinical agent. Despite its potent antitumor activity, use etoposide limited because effects, including myelosuppression and the development secondary leukemia. Here, we comprehensively compared mechanistic differences between daurinol they have similar chemical structures. Etoposide, topoisomerase II poison, known to attenuate cancer...

One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% stage worldwide, and the clinical outcomes remarkably varied difficult to predict. One miRNAs known be associated with tumorigenesis miR-944. However, prognostic value miR-944 has not been fully investigated. aim this study was analyze significance cancer. expression levels were detected using quantitative reverse transcription polymerase chain reaction five...

Diabetes is a risk factor for breast cancer development and associated with poor prognosis patients. However, the molecular biochemical mechanisms underlying association between diabetes have not been fully elucidated. Here, we investigated estradiol response in MCF-7 cells or without chronic exposure to insulin. We found that insulin priming necessary specific estradiol-induced cell growth, induces anaplerotic shunting of glucose into macromolecule biosynthesis treated cells. Treatment ERK...

Human papillomavirus (HPV) is a major cause of cervical cancer, which the second most common cancer in women. HPV E6 initiates degradation cellular tumor suppressor protein p53, induces human telomerase reverse transcriptase (hTERT) activity, and then leads to progressive carcinogenesis.In this study, CervicGen RT-qDX assay (Optipharm, Osong, Republic Korea), detects 16 high-risk subtypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 69), hTERT (Optipharm) were evaluated...

Abstract Introduction The anaphase-promoting complex (APC) is a multiprotein with E3 ubiquitin ligase activity, which required for the ubiquitination of securin and cyclin-B. Moreover, mitotic spindle checkpoint activated if APC activation prevented. In addition, several APC-targeting molecules such as securin, polo-like kinase, aurora SnoN have been reported to be oncogenes. Therefore, dysregulation may associated tumorigenesis. However, clinical significance involvement in tumorigenesis...

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and it responsible for cases of cervical uterine cancer. Although HPV infections cervix do not always progress to cancer, 90% cancer have been found be associated with high risk (HR-HPV) infection. DNA testing widely used, along Papanicolaou (Pap) testing, screen abnormalities. However, there are no data on prevalence genotype-specific assessed by measuring E6/E7 mRNA in women representative...

Large cell lymphoma (LCL) sometimes occurs concurrently or subsequently in patients with nodular lymphocyte-predominant Hodgkin disease (NLPHD). Although there is evidence of a clonal relationship between LCL and NLPHD, has been no direct demonstration that the lymphocytic histiocytic (L&H) cells NLPHD are related to tumor LCL. We identified 2 cases an associated Single L&H cells, Reed-Sternberg variants were isolated from immunostained tissue sections by micromanipulation, immunoglobulin...

Abstract This study was conducted to evaluate the overall performance of a reverse blot hybridization‐based assay, REBA HPV‐ID® (Molecules and Diagnostics, Wonju, Korea) for genotyping human papillomaviruses (HPV). HPV Genotyping on 356 specimens examined cytologically performed using HPV‐ID®, its results were compared with those obtained MyHPV DNA Chip® (Mygene, Seoul, Korea), chip‐based assay. The from this showed that positivity rate abnormal cytological samples higher (80.9%) than chip...

Purpose: ROS1 is an oncogene, expressed primarily in glioblastomas of the brain that has been hypothesized to mediate effects early stage tumor progression.In addition, it was reported expression observed diverse cancer tissue or cell lines and associated with development several tumors.However, not studied breast date.Therefore, we investigated at protein gene level compare patterns verify association prognostic factors invasive ductal carcinoma (IDC) breast.Materials Methods: Tissue...

The effect of cyclin D1 overexpression on breast cancer outcomes and prognosis is controversial, even though amplification the gene, CCND1, has been shown to be associated with early relapse poor prognosis. In this study, we examined relationship between disease-specific survival (DSS). We also analyzed in patients who experienced recurrence.We retrospectively data from diagnosed ductal carcinoma April 2005 December 2010. clinicopathologic factors influence recurrence-free DSS.We identified...

Human papillomavirus (HPV) infection is a major cause of premalignant dysplasia and cervical cancer. There are no data on the prevalence genotype-specific HPV assessed by E6/E7 mRNA in women representative Korean population across broad age range.A total 630 aged 17-90 years were enrolled this study. ThinPrep liquid-based cytology samples evaluated using CervicGen RT-qDx assay, which detects 16 high-risk (HR) genotypes (set 1: 16, 31, 33, 35, 52, 58; set 2: 18, 39, 45, 51, 59, 68; 3: 53, 56,...

Background: Histone deacetylase 1 (HDAC1) is associated with the expression and function of estrogen receptors proliferation tumor cells, has been considered a very important factor in breast progression prognosis.Several studies have reported an association between HDAC1 poorer prognosis cancers including cancer, few exceptions.However, because dearth on its significance for cancer not well defined.Therefore, we examined invasive ductal carcinoma (IDC), most common investigated potential...

Cardiovascular autonomic dysfunction, which is manifested by an impairment of the arterial baroreflex, prevalent irrespective etiology and contributes to increased morbidity mortality in cirrhotic patients. However, cellular mechanisms that underlie cirrhosis-impaired baroreflex remain unknown. In present study, we examined whether attributable dysfunction aortic baroreceptor (AB) neurons. Biliary nonbiliary rats were generated via common bile duct ligation (CBDL) intraperitoneal injections...

Purpose The anaphase-promoting complex (APC) is a multiprotein with E3 ubiquitin ligase activity and required for ubiquitination of securin cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation APC may associated tumorigenesis. This study examines the relationship between expression clinicopathological factors evaluates possibility an aberrant function in colorectal carcinomas (CRCs). Methods To determine whether loss APC7 related tumorigenesis, we used tissue...

Unilateral or bilateral non-Hodgkin's lymphomas arising primarily in the adrenal glands are extremely rare. These usually present with large, masses without lymphadenopathy, and may be accompanied by insufficiency some cases. A review of literature indicates that patients primary lymphoma do not have disease elsewhere, if present, it is frequently extranodal. We report here an unusual case partial insufficiency.

p63 is a transcription factor p53 family. Two major isoforms of p63, TAp63 with transactivation (TA) domain and ΔNp63 truncated TA domain, have been reported to play opposing roles either in tumor suppression or oncogenic function. Little known about the association these two carcinogenesis cervical cancer. In this study, mRNA expression levels 40 normal, 30 low-grade squamous intraepithelial lesions (LSIL), 38 high-grade (HSIL), 52 cancer formalin-fixed paraffin-embedded tissues were...

<i>Objective:</i> To investigate the association of apoptosis with apoptotic proteins and Epstein-Barr virus (EBV) expression in gastric carcinoma lymphoid-rich stroma (GCLRS) order to clarify relationship between lymphocytic infiltration, EBV carcinoma. <i>Subjects Methods:</i> We performed immunohistochemical stains for bcl-2, bax situ hybridization EBV-encoded RNA terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling technique using 24...