A5100384996- Fibroblast Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Phytochemicals and Antioxidant Activities
- Nutrition, Health and Food Behavior
- Food Quality and Safety Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Natural Antidiabetic Agents Studies
- Alcohol Consumption and Health Effects
- Healthcare and Venom Research
- Mitochondrial Function and Pathology
- VLSI and Analog Circuit Testing
- Adipokines, Inflammation, and Metabolic Diseases
- Angiogenesis and VEGF in Cancer
- Diet, Metabolism, and Disease
- Stroke Rehabilitation and Recovery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Fungal Biology and Applications
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Disease Prevention
- Cancer, Hypoxia, and Metabolism
Sungkyunkwan University
2019-2025
Yonsei University
2014-2024
Severance Hospital
2017-2024
Seoul National University Hospital
2023
Korea Institute of Oriental Medicine
2023
Chungbuk National University
2011-2023
Yonsei University Health System
2010-2023
CHA University
2023
CHA Gangnam Medical Center
2023
Samsung Medical Center
2019-2020
This study investigated the hypoglycemic, hypolipidemic, and antioxidant effects of dietary quercetin in an animal model type 2 diabetes mellitus. Four-week-old C57BL/KsJ-db/db mice (n = 18) were offered AIN-93G diet or a containing at 0.04% (low quercetin, LQE) 0.08% (high HQE) for 6 weeks after 1 week adaptation. Plasma glucose, insulin, adiponectin, lipid profiles, peroxidation liver determined. glucose levels significantly lower LQE group than control group, those HQE even further...
Interleukin (IL)-33, an IL-1 family member, acts as extracellular cytokine by binding its cognate receptor, ST2. IL-33 is also a chromatin-binding transcriptional regulator highly expressed in the nuclei of endothelial cells. However, function nuclear factor poorly defined. Here, we show that novel p65 subunit NF-κB complex and involved cell activation. Quantitative reverse transcriptase PCR Western blot analyses indicated mediates expression intercellular adhesion molecule (ICAM)-1 vascular...
The phosphoinositide 3-kinase-Akt signaling pathway is essential to many biological processes, including cell proliferation, survival, metabolism, and angiogenesis, under pathophysiological conditions. Although 3-phosphoinositide-dependent kinase 1 (PDK1) a primary activator of Akt at the plasma membrane, optimal activation mechanism remains unclear. We report that adhesion molecule with IgG-like domain 2 (AMIGO2) novel scaffold protein regulates PDK1 membrane localization activation. Loss...
Sageretia thea is used in the preparation of herbal medicine China and Korea; this plant rich various bioactive compounds, including phenolics flavonoids. The objective current study was to enhance production phenolic compounds cell suspension cultures thea. Optimum callus induced from cotyledon explants on MS medium containing 2,4-dichlorophenoxyacetic acid (2,4-D; 0.5 mg L-1), naphthalene acetic (NAA, kinetin (KN; 0.1 L-1) sucrose (30 g L-1). Browning successfully avoided by using 200 L-1...
Osteocytes are increasingly recognized as significant sources of osteoclast differentiation factor, receptor activator nuclear factor-κB ligand (RANKL), and osteoblast inhibitory sclerostin. In this study, RANKL sclerostin expression osteocytes is investigated in rats with ligature-induced periodontitis.Rats were divided into control periodontitis groups, was induced by ligature on the mandibular first molars. At 1, 3, 10, 20 days after ligature, histologic analyses alveolar bone (AB)...
// Mohamed Badawi 1, * , Jihye Kim Anees Dauki 1 Dhruvitkumar Sutaria 3 Tasneem Motiwala 2 Ryan Reyes Nissar Wani Shamalatha Kolli 4 Jinmai Jiang Christopher C. Coss Samson T. Jacob Mitch A. Phelps and Thomas D. Schmittgen College of Pharmacy, Medicine, The Ohio State University, Columbus, OH, USA Department Molecular Cellular Biochemistry, University Florida, Gainesville, FL, Comprehensive Cancer Center, These authors contributed equally to this work Correspondence to: Schmittgen, email:...
Controlled angiogenesis and lymphangiogenesis are essential for tissue development, function, repair. However, aberrant neovascularization is an pathogenic mechanism in many human diseases, including diseases involving tumor growth survival. Here, we have demonstrated that mice deficient C-type lectin family 14 member A (CLEC14A) display enhanced angiogenic sprouting hemorrhage as well enlarged jugular lymph sacs lymphatic vessels. CLEC14A formed a complex with VEGFR-3 endothelial cells...
Postmenopausal women are vulnerable to aging and oxidative stress due reduced estrogen. Previous studies have shown that Korean red ginseng (KRG) has beneficial effects on antioxidant capacity. Therefore, we evaluated the of KRG biological capacity in postmenopausal women. This study conducted a double-blinded, placebo-controlled clinical trial. The participants were randomly administered or placebo, following metrics measured: mitochondria DNA (mtDNA) copy number as an indicator and, total...
Abstract Background and Aims Cardiovascular disease (CVD) is the main cause of mortality in subjects with non‐alcoholic fatty liver (NAFLD). We investigated association between CVD risk metabolic dysfunction‐associated (MAFLD) or NAFLD influence significant fibrosis on risk. Methods Subjects who underwent a comprehensive medical check‐up were recruited (2014–2019). Significant was defined using score, fibrosis‐4 index, aspartate aminotransferase to platelet ratio FibroScan‐aspartate score....
Abstract Since 2009, the Korea Meteorological Administration (KMA) has participated in ground validation (GV) projects through international partnerships within framework of Global Precipitation Measurement (GPM) Mission. The goal this work is to assess reliability ground-based measurements Korean Peninsula as a means for validating precipitation products retrieved from satellite microwave sensors, with an emphasis on East Asian precipitation. KMA well-developed operational weather service...
Modulating endothelial progenitor cells (EPCs) is essential for therapeutic angiogenesis, and thus various clinical trials involving EPCs are ongoing. However, the identification of environmental conditions development optimal methods required to accelerate EPC-driven vasculogenesis.We evaluated gene expression profiles cord blood-derived identify key factors in EPC→endothelial cell differentiation show that transforming growth factor-β family members contribute EPC differentiation. The...
Introduction: This study aims to investigate the association between gender discrimination in workplace and pregnancy planning/childbirth experiences among working women South Korea. Methods: We analyzed data from Korean Longitudinal Survey of Women Families (KLoWF) for years 2007 2016. The population consisted 7996 women, ages 19 45. Gender was measured through 6-item Workplace Discrimination Scale, evaluating terms recruitment, promotions, pay, deployment, training lay-offs. Multiple...
Abstract The purpose of this study is to investigate the association between handgrip strength (HGS) and health-related quality life (HRQoL), demonstrating HGS as an effective indicator for evaluating HRQoL patients with cancer. Analyzing 1657 Korean adult cancer (644 males, 1013 females) aged ≥ 20 years from Korea National Health Nutrition Examination Survey (2014–2019), was standardized based on body mass index categorized by sex. assessed using Euro Quality Life-5-Dimension 3-Level...
Objective To investigate the efficacy of different doses soluble form receptor for advanced glycation end products (sRAGE) (conjugated to Fc portion immunoglobulin) in treatment nephritis lupus‐prone mice, comparison with combination therapy mycophenolate mofetil plus prednisolone. Methods Twenty‐eight female (NZB/NZW)F1 mice were divided into 5 groups (untreated, sRAGE [dose 0.5, 1, or 2 μg], prednisolone). Proteinuria and histologic damage evaluated. Immune complex deposition nuclear...
The fatty liver index (FLI) is a simple and non-invasive method for the diagnosis of disease with an increased risk cardiovascular (CVD) as well liver-related mortality. We examined association between FLI 10-year CVD determined by Framingham score.This cross-sectional study included 7,240 individuals aged 30 to 69 years who underwent health examination 2015 2017. was calculated using algorithm based on triglyceride, γ-glutamyltransferase, body mass (BMI), waist circumference. Multiple...
Tight control of blood glucose is the most important strategy for treatment diabetes mellitus.Here, we investigated beneficial effects Welsh onion on fasting and postprandial hyperglycemia.Inhibitory activities hot water extracts from green stalk white bulb, which are edible portions onion, fibrous root extract against yeast α-glucosidase were measured in vitro.To study hyperglycemia, a starch solution (1 g/kg) with without (500 mg/kg) or acarbose (50 was administered to...
Early prediction of treatment outcomes represents an essential step towards increased efficacy and survival in patients with hepatocellular carcinoma (HCC). In this study, we performed two-dimensional electrophoresis (2-DE) followed by protein profiling to identify biomarkers predictive therapeutic HCC who received liver-directed therapy (LDTx) involving local radiotherapy (RT), studied the underlying mechanisms identified proteins.2-DE analysis was conducted pooling sera from a good or poor...
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using Mendelian randomization approach. pooled genome-wide association summary statistics 18 two phenotypes: any (