A5101902030- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Sarcoidosis and Beryllium Toxicity Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Urticaria and Related Conditions
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Spondyloarthritis Studies and Treatments
- IgG4-Related and Inflammatory Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Platelet Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Bone and Joint Diseases
Yonsei University
2016-2025
Yonsei University Health System
2023-2024
Center for Rheumatology
2017-2023
Severance Hospital
2009-2023
Cancer Research And Biostatistics
2022
Korea Health Industry Development Institute
2022
Celltrion (South Korea)
2022
National Health Insurance Service
2022
National Health Insurance Service Ilsan Hospital
2022
Hallym University Sacred Heart Hospital
2022
We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is most widely used disease-modifying anti-rheumatic drug (DMARD) RA, and RGD peptide a targeting moiety inflammation. Upon near-infrared (NIR) irradiation, heat locally generated due to Au half-shells, release rate enhanced, delivering inflamed joints simultaneously. RA chronic inflammatory disease characterized by synovial inflammation in...
Objective To investigate baseline and change of pulmonary damage biomarkers (serum Krebs von den Lungen 6 [KL-6], human surfactant protein D [hSP-D], matrix metalloproteinase 7 [MMP-7]) with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) progression. Methods In the Korean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) cohort, a prospective we enrolled patients RA ILD confirmed by chest computed tomography imaging followed annually. progression was defined as...
Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients.We used high-resolution B-mode ultrasound compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women and controls matched by age, sex, menopause status. No subject either group had a history or its complications. investigated the association IMT relevant...
Natural Abs, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis, but their role in innate immunity remains poorly understood. Herein, we show the response to neoantigenic determinants on apoptotic thymocytes is dominated by Abs oxidation-associated Ags, phosphorylcholine (PC), a head group becomes exposed during programmed cell death, and malondialdehyde (MDA), reactive aldehyde degradation product of polyunsaturated lipids...
Differences in Clinical Manifestations and Outcomes between Adult Child Patients with Henoch-Schönlein PurpuraWe aimed to investigate differences clinical manifestations outcomes adult child patients purpura (HSP), analyze the factors associated poor prognosis for HSP nephritis.This retrospective 10-yr study enrolled 160 who visited Severance Hospital.Purpura was mostly detected lower extremities, but upper extremities more frequently observed adults than children (41.7% vs 19.3%).Children...
To explore the course of lung function and RA disease activity predictive factors for deteriorating in patients with RA-interstitial (ILD).The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients RA-ILD were enrolled followed up annually 3 years ILD status assessment. Group-based modelling was used to cluster similar predicted percentage forced vital capacity (FVC%) patterns into trajectories.This study included 140 who...
To investigate whether anti-tumor necrosis factor-alpha (TNF-alpha) therapy can influence the reactivation of hepatitis B virus (HBV) infection in inactive HBsAg carriers.The medical records 103 patients [59 with ankylosing spondylitis (AS), 41 rheumatoid arthritis (RA), 2 juvenile RA, and 1 psoriatic arthritis] who had been treated anti-TNF-alpha were reviewed retrospectively. Data on seropositivity HBV, HBV load, serum aminotransferases prior to after initiation obtained.Eight carriers,...
The assessment of disease activity in Takayasu arteritis (TA) is difficult clinical situations because symptoms and laboratory parameters do not always reflect the actual inflammation arterial wall. We undertook this study to comprehensively investigate role (18) F-fluorodeoxyglucose-positron emission tomography (FDG-PET) patients with TA.We performed a retrospective chart review 53 FDG-PET scans 38 TA. measured F-fluorodeoxyglucose ((18) F-FDG) accumulation vascular wall large vessel using...
Recent reports have associated NCF2, encoding a core component of the multi-protein NADPH oxidase (NADPHO), with systemic lupus erythematosus (SLE) susceptibility in individuals European ancestry. To identify ethnicity-specific and -robust variants within we assessed 145 SNPs around NCF2 gene 5325 cases 21 866 controls European-American (EA), African-American (AA), Hispanic (HS) Korean (KR) Subsequent imputation, conditional, haplotype bioinformatic analyses identified seven potentially...
This study was performed to determine whether the serum concentrations of interleukin (IL)-6 family cytokines are elevated in patients with rheumatoid arthritis (RA) and investigate relationship between IL-6 cytokine levels disease activity RA patients.We obtained samples from 40 age- sex- matched healthy controls, we assessed clinical parameters activity, including 28-joint score (DAS28) C-reactive protein (CRP) levels. Serum five high (DAS28 > 5.1) were also collected at eighth week...
<h3>Objectives</h3> To identify novel genetic candidates for systemic lupus erythematosus (SLE) in the Korean population, and to validate risk loci SLE identified previous genome-wide association studies (GWAS). <h3>Methods</h3> We performed a GWAS 400 female patients 445 controls. Selected single-nucleotide polymorphisms (SNP) were then replicated an independent cohort of 385 583 controls (replication 1), further 811 1502 2). <h3>Results</h3> In phase, rs9275428 located near <i>HLA-DQB1</i>...
Objective. To evaluate the clinical significance of 2016 European League Against Rheumatism (EULAR)/American College Rheumatology (ACR)/Pediatric International Trials Organization (PRINTO) classification criteria for macrophage activation syndrome (MAS) in patients with adult-onset Still disease (AOSD). Methods. We performed a retrospective analysis AOSD fever who were admitted to Severance Hospital between 2005 and 2016. The evaluated MAS using MAS. Clinical features, laboratory findings,...
ABSTRACT Objectives We investigated whether systemic immune‐inflammation index (SII) at diagnosis can estimate the cross‐sectional high activity and predict poor outcomes in immunosuppressive drug‐naïve patients with antineutrophil cytoplasmic antibody‐associated vasculitis (AAV). Methods retrospectively reviewed medical records of 163 AAV obtained clinical laboratory data. calculated Birmingham score (BVAS) as well five‐factor (FFS) (2009) diagnosis. SII was by equation (SII = platelet...
Purpose: We investigated whether C-reactive protein (CRP) to serum albumin ratio (CAR) could be an independent predictor of all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Materials and Methods:We retrospectively reviewed the medical records 170 AAV.We collected clinical laboratory data.We also examined AAV-related traditional risk factors mortality.To assess hazard ratios variables, we performed univariable multivariable Cox model...
Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the and type Korean IgG4-RD patients.Clinical laboratory results fulfilling comprehensive diagnostic criteria for were retrospectively collected between January 2006 November 2015. One hundred eighteen included, 35 classified as having definite, 83 possible/probable IgG4-RD. We compared baseline clinical variables definite those calculated...
Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization HLA effects extremely challenging. As result, the contribution specific alleles and amino-acid residues to overall SLE autoantibodies are far from completely understood. Here, we dissected (a) association signals across HLA, (b) HLA-peptide interaction, (c) residue-autoantibody association. Classical alleles, SNPs, eight genes were imputed 4,915...