A5058254590- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Technologies
- Genetic factors in colorectal cancer
- Reproductive Biology and Fertility
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Breast Implant and Reconstruction
- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Cancer and Skin Lesions
- Ovarian function and disorders
- HER2/EGFR in Cancer Research
- Mobile Health and mHealth Applications
- Retinoids in leukemia and cellular processes
- MRI in cancer diagnosis
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Statistical Methods in Clinical Trials
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
Ajou University
2023-2024
University of Ulsan
2019-2023
Asan Medical Center
2013-2023
Ulsan College
2019-2023
University of Tennessee at Knoxville
2009
To determine the updated long-term outcomes of Addition Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial.This study is a post-trial follow-up ASTRRA trial, involving 1,483 premenopausal women younger than 45 years treated with definitive surgery after completing adjuvant neoadjuvant chemotherapy for estrogen receptor-positive breast cancer. Patients were randomly assigned...
Abstract Genomic alterations in tumors play a pivotal role determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as key tool over the past decade, but advancements costs bioinformatics have now made whole-genome (WGS) feasible single-assay approach for almost all cancer genomes settings. This paper reports on findings of prospective, single-center study exploring real-world utility WGS (tumor matched normal tissues) two primary...
506 Background: Addition of Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial, at 63 months median follow-up, showed that the addition 2 years ovarian function suppression (OFS) (TAM) significantly improved disease-free survival (DFS) compared with TAM alone patients hormone receptor–positive breast cancer who remain a premenopausal state resume after chemotherapy. We...
Abstract Genomic alterations in tumors play a pivotal role determining their clinical trajectory and responsiveness to treatment. While targeted panel sequencing ( TPS ) has been key tool over the past decade, advancements costs bioinformatics have now made whole-genome WGS feasible single-assay approach for almost all cancer genomes settings. This paper reports on findings of prospective, single-center study exploring real-world utility (tumor matched normal tissues) with two primary...
Physical activity (PA) in patients with breast cancer is associated improved quality of life (QoL); however, many survivors do not meet the recommended PA level. This study aims to evaluate effect digital health interventions using mobile apps promote and QoL postoperative cancer. will also identify effective intervention methods perform an economic analysis. The main hypothesis that use healthcare improve health-related (HRQOL), PA, reduce costs.The Promotion a better lifestyle Precise...
To evaluate the clinical course and long-term outcomes of patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) identify independent prognostic factors for further recurrence.In this retrospective study, we reviewed records 327 who experienced IBTR undergoing BCS cancer at Asan Medical Center during 1990-2013. Overall survival (OS) cumulative incidence rates recurrences were calculated. The association clinicopathological development was determined in...
In total mastectomy (TM), sentinel lymph node biopsy (SLNB) is recommended but can be omitted for breast-conserving surgery (BCS) in patients with ductal carcinoma
e13060 Background: Activating mutations ofESR1 and PIK3CA genes are known mechanisms of endocrine resistance. Recent analysis supported benefit early intervention at presence ESR1 mutation in blood (bESR1) before clinical progression. We aimed to investigate detected cell-free DNA (cfDNA) from patients with hormone receptor-positive, HER2-negative metastatic breast cancer (MBC) its impact on progression-free survival (PFS). Methods: Thirty undergoing 1 st line therapy (ETx) were identified a...
The extension of endocrine therapy beyond 5 years for recurrence-free survivors breast cancer improves survival; however, the issue on how to clinically identify appropriate candidates remains controversial. This study aimed prognostic factors breast-cancer-specific mortality in patients who have had tamoxifen treatment and categorize subgroups based risk death using combinations these assist clinical decision perform further therapy.In total, 3,158 with were enrolled. Breast cancer-specific...
Fertility is an important issue for young women with breast cancer, but studies about physicians' knowledge, attitudes, and practices toward fertility preservation (FP) are largely based on Western populations do not reflect recent international guidelines FP. In this study, we aimed to assess the of physicians from South Korea, other Asian countries, Latin America FP in identify related barriers. The survey was conducted anonymously among involved cancer care between November 2020 July...
Fertility preservation (FP) is an important issue for young survivors of breast cancer. Although international guidelines recommend pre-treatment fertility counseling women with cancer, there no standardized protocol or referral system FP in South Korea. There are also barriers to discussing that make patient-centered decision making difficult. This study aimed develop a shared program and compare the rates procedures between usual care groups. We hypothesized multidisciplinary would...
Tumor localization is challenging in the context of ductal carcinoma situ (DCIS) treated with breast-conserving surgery. Conventional methods are generally performed under guidance ultrasonography or mammography and rarely magnetic resonance imaging (MRI), which more sensitive than aforementioned modalities detecting DCIS. Here, we report application MRI-based individualized 3-dimensional (3D)-printed breast surgical guides (BSGs) for patients cancer. We successfully resected indeterminate...
Abstract Objective Occult breast cancer (OBC) is a rare presentation which accounts for 0.3-1.0% of all cancers. In spite limited information, there no consensus regarding the prognostic factors and treatment OBC. This retrospective study intends to evaluate overall survival occult in Korea. Method included 142 pathologic patients from January 1990 December 2009, identified Korean Breast Cancer Society registry. All had pathologically positive axillary lymph node (N1-N3) along with &...
Abstract #3056 Recent studies have suggested that ERβ may oppose actions of ERα in breast cancer cells and clinical indicate loss expression positive tumors is associated with a poor prognosis perhaps resistance to tamoxifen therapy. Clinical evidence indicates post menopausal women hormone replacement therapy significantly decreased incidence colon cancer, suggesting estrogens protective role . We recently found SW 480 cells, (ER negative) stable SKP2, c-myc but not p27kip1 mRNA measured by...