Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson’s disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing nested case-control design, study explored subsequent occurrences in Korean adults, leveraging validated national population-based dataset covering period from 2002 to 2019. It included 8794 patients 35,176 matched control individuals,...

Objective: The association between periodontitis and benign prostatic hyperplasia (BPH) has been controversial. This study aimed to estimate the recurrent episodes occurrence of BPH in an adult male population Korea. Methods: analyzed data from 79,497 matched cases controls examine relationship BPH, using Korean National Health Insurance Service-Health Screening Cohort data. Conditional logistic regression was used calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting...

Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders, but their potential association with lung cancer risk and mortality remains underexplored debated. This study sought to investigate the between PPI use likelihood mortality, focusing on impact of exposure history duration. utilized data from 6795 patients, 27,180 matched controls, 4257 deceased 2538 surviving patients Korean National Health Insurance Service's Screening Cohort (2002-2019). Propensity...

Chronic periodontitis (CP) has been linked to an increased risk of sudden sensorineural hearing loss (SSNHL). This study aimed delineate the causal relationships between CP and SSNHL. Data from 40-year-old participants in Korean National Health Insurance Service-Health Screening Cohort 2002 through 2019 were used. The data 13,769 patients with SSNHL collected matched those 55,076 control terms demographic socioeconomic variables. incidence before onset was recorded. odds ratios (ORs) for...

Aim To compare the efficacy and safety between modified quadruple- bismuth-containing quadruple therapy as first-line eradication regimen for Helicobacter pylori infection.Methods This study was a multicenter, randomized-controlled, non-inferiority trial. Subjects endoscopically diagnosed with H. infection were randomly allocated to receive (rabeprazole 20 mg bid, amoxicillin 1 g metronidazole 500 tid, bismuth subcitrate 300 qid [elemental 480 mg]; PAMB) or qid, tetracycline qid; PBMT) 14...

Esophageal cancer constitutes a global public health challenge. However, South Korean population-specific information on the association of lifestyle (smoking, alcohol consumption, and obesity status) with esophageal risk is sparse. This nested case–control study analyzed national screening cohort data (2002–2019) 1114 patients 4456 controls (1:4 propensity-score matched for sex, age, income, residential region). Conditional unconditional logistic regression analyses, after adjustment...

Rectal neuroendocrine tumors (NETs) are the most common gastrointestinal (GI) NETs with an uncertain malignant potential despite their small size. There limited data about driver mutations in rectal NETs, which may explain tumors' unexpected behavior or histologic morphology other GI-NETs. Here, we investigated clinically and pathologically relevant of nonrectal compared frequency clinical significance detected between them. We sequenced 84 primary GI-NETs (69 rectal, 7 gastric, 5...

Background: The prognostic relevance of the PIK3CA mutation together with PD-L1, c-Met, and mismatch repair deficiency (dMMR) have not been fully investigated in Asian women breast cancer (BC) who undergone postoperative adjuvant chemotherapy. Methods: We analyzed mutations via peptide nucleic acid (PNA)-mediated real-time PCR assay, PD-L1/c-Met expression immunohistochemistry (IHC), microsatellite instability (MSI) status using IHC, 191 resected BCs from 2008 to 2011. Cancer Genome Atlas...

Although safety concerns regarding proton pump inhibitor (PPI)/H2-receptor antagonists (H2RA) in the incident esophageal cancer have been raised, Asian-based report is unclear. We investigated estimated likelihood of cancer—its mortality depending on prior history PPI/H2RA use—and gastroesophageal reflux disease (GERD) Koreans. Using Korean National Health Insurance Service-Health Screening Cohort data (2002−2015), a case−control study was retrospectively conducted, including 811 patients...

AIMTo identify the frequency, clinicopathological risk factors, and prognostic significance of lymphovascular invasion (LVI) in endoscopically resected small rectal neuroendocrine tumors (NETs). METHODSBetween June 2005 December 2015, 104 cases (≤ 1 cm) NET specimens at Hallym University Sacred Heart Hospital Korea were retrospectively evaluated.We compared detected rate LVI by two methods: hematoxylin eosin (H&E) ancillary immunohistochemical staining (D2-40 Elastica van Gieson); addition,...

We investigated whether the coronavirus disease 2019 (COVID-19) pandemic, in conjunction with public health measures, influenced incidence of gastrointestinal diseases according to age and sex during pandemic. Changes monthly rates (January 2018 June 2021) common were assessed using data from Korean National Health Insurance Service by comparing two periods: before COVID-19 2018-February 2020) (March 2020-June 2021). The Mann-Whitney

The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due inconsistent results Asian Western countries. We explored the long-term association of RA with overall organ-specific using nationwide population data. This longitudinal follow-up study (2002–2015) included 3070 patients 12,280 controls (1:4 propensity score-matched for sex, age, residence, income) from Korean National Health Insurance Service-Health Screening Cohort database. A Cox...

Data regarding driver mutation profiles in tonsillar squamous cell carcinomas (TSCCs) remain scarce, limiting the understanding of its pathogenesis and unexpected behavior updated staging system. We investigated incidence clinically relevant mutations their contribution prognosis condition, association with human papillomavirus (HPV) infection adjuvant therapy. subjected 43 surgically resected TSCC samples to targeted next-generation sequencing, determined HPV status using polymerase chain...

With increasing interest in the inflammation-pathogen infection hypothesis and its potential links to Alzheimer’s disease (AD) development, there is growing consideration of using upper respiratory (URI) treatments as interventions for AD. This nested case–control study explored association between prior URI histories AD development a Korean adult population national health screening cohort data (2002–2019). The included 26,920 patients 107,680 matched control individuals, focusing on those...

Gastric cancer (GC) survivors may be more likely to develop osteoporosis. However, few studies on the relationship between GC and osteoporosis have been conducted large patient populations. We aimed determine incidence of identify related factors by comparing patients with matched controls using Korean National Health Insurance Service—National Sample Cohort (KNHIS-NSC). This study included 9078 36,312 (1:4 propensity score-matched for sex, age, residence, income). The hazard ratio (HR) was...

This paper describes the fabrication of a backlight unit for liquid crystal display based on printed carbon nanotube field emitters with lateral gate and additional mesh structures. The device architecture has been optimized through emission characterization supporting numerical simulation. current depends strongly cathode-gate gap, position, bias. Direct observation luminous images phosphor screen reveals that electron beams undergo noticeable shrinkage along direction increasing anode...

Gastroesophageal reflux disease (GERD) can be classified into erosive (ERD) and nonerosive gastroesophageal (NERD). We aimed to compare the recurrence rates of ERD NERD determine risk factors related recurrence.This prospective study comprised 337 consecutive adults who completed questionnaires on their GERD symptoms, height, weight, sleeping position, dinner time, bedtime. During upper gastrointestinal endoscopy, presence a hiatal hernia mucosal breaks in low esophagus, esophageal length...

Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as upregulator PD-L1 overexpression through oncogenic pathway. However, association between expression with has not been in gastric cancer.The prognostic significance of its Epstein-Barr virus (EBV), microsatellite instability (MSI), mucin phenotype remain controversial. We performed situ hybridization EBV-encoded RNA...

Concerns about the hazards of statins on development and mortality stomach cancers remain controversial. Here, we investigated likelihood incident gastric related depending statin exposure, type, duration use. This nested case-control-designed study was composed 8798 patients who were diagnosed with cancer matched 35,192 controls at a 1:4 ratio based propensity scores age, sex, residential area, income from Korean National Health Insurance Service-Health Screening Cohort database...

Chronic kidney disease (CKD) and Alzheimer's (AD) are common chronic diseases in the elderly population. Although a relationship between CKD occurrence of AD has been proposed, previous research results have disputed, further investigation is necessary to confirm this relationship. In longitudinal follow-up study, we examined data from Korean National Health Insurance Service-Health Screening Cohort, consisting 15,756 individuals with 63,024 matched controls aged ≥40 years who received...