A5006546598- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Hereditary Neurological Disorders
- Gastroesophageal reflux and treatments
- Bioinformatics and Genomic Networks
- Helicobacter pylori-related gastroenterology studies
- Algorithms and Data Compression
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Chronic Kidney Disease and Diabetes
- Genomic variations and chromosomal abnormalities
- Restraint-Related Deaths
- Migraine and Headache Studies
- Advanced Image and Video Retrieval Techniques
- Bipolar Disorder and Treatment
- Acute Myeloid Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Blood properties and coagulation
- Sepsis Diagnosis and Treatment
- Inflammatory Bowel Disease
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
Hallym University Medical Center
2016-2025
Hallym University
2007-2022
Background Most studies of smartphone-based assessments motor symptoms in Parkinson's disease (PD) focused on gait, tremor or speech. Studies evaluating bradykinesia using wearable sensors are limited by a small cohort size and study design. We developed an application named smartphone tapper (SmT) to determine its applicability for clinical purposes compared SmT parameters current standard methods larger cohort. Methods A total 57 PD patients 87 controls examined with UPDRS underwent timed...
Esophageal cancer constitutes a global public health challenge. However, South Korean population-specific information on the association of lifestyle (smoking, alcohol consumption, and obesity status) with esophageal risk is sparse. This nested case–control study analyzed national screening cohort data (2002–2019) 1114 patients 4456 controls (1:4 propensity-score matched for sex, age, income, residential region). Conditional unconditional logistic regression analyses, after adjustment...
Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders, but their potential association with lung cancer risk and mortality remains underexplored debated. This study sought to investigate the between PPI use likelihood mortality, focusing on impact of exposure history duration. utilized data from 6795 patients, 27,180 matched controls, 4257 deceased 2538 surviving patients Korean National Health Insurance Service's Screening Cohort (2002-2019). Propensity...
Studies regarding differentially expressed genes (DEGs) in Parkinson's disease (PD) have focused on common upstream regulators or dysregulated pathways ontologies; however, the relationships between DEGs and disease-related cell type-enriched not been systematically studied. Meta-analysis of (meta-DEGs) are expected to overcome limitations, such as replication failure small sample size previous studies.Meta-DEGs were performed investigate enriched with neurodegenerative disorder causative...
Chronic kidney disease (CKD) and Alzheimer's (AD) are common chronic diseases in the elderly population. Although a relationship between CKD occurrence of AD has been proposed, previous research results have disputed, further investigation is necessary to confirm this relationship. In longitudinal follow-up study, we examined data from Korean National Health Insurance Service-Health Screening Cohort, consisting 15,756 individuals with 63,024 matched controls aged ≥40 years who received...
Safety issues regarding the potential risk of statins and incident rheumatoid arthritis (RA) have been raised, but existing data are largely based on Caucasian populations, continue to biases require further validation in Asian populations. Here, we aimed verify RA depending duration previous statin use types using a large-scale, nationwide database. This study enrolled 3149 patients with 12,596 matched non-RA participants from national health insurance database (2002–2015), investigated...
ABSTRACT Background and Objectives Many hereditary movement disorders with complex phenotypes without a locus symbol prefix for familial PD present as parkinsonism; however, the dysregulation of genes associated these in SNpc patients has not been systematically studied. Methods Gene set enrichment analyses were performed using 10 previously published genome‐wide expression datasets obtained by laser‐captured microdissection pigmented neurons SNpc. A custom‐curated gene parkinsonism...
The effect of proton pump inhibitor (PPI) use on migraine risk remains controversial. We explored the odds migraines in relation to prior PPI and treatment duration. Data from Korean National Health Insurance Service-Health Screening Cohort (2002−2015) were analyzed this nested case-control study involving 28,159 participants with incident 112,636 controls (1:4 matched by sex, age, income, residential region). baseline covariates balanced performing propensity score overlap weighting-based...
Background: Automated hematology analyzers report various research parameters.Certain parameters may have clinical implications, whereas others are used to set flags in automated analyzers.In this study, we established sex-specific reference intervals for one reticulocyte parameter and two platelet clump Korean adults examined the necessity of separate each sex.Methods: A total 264 healthy (157 men 107 women) aged between 18 65 years who underwent regular health check-ups were...
Epidemiological studies have suggested the role of multiple genetic and environmental factors in development non-neoplastic gastrointestinal (GI) diseases; however, little information is available on these Korean population. Therefore, this cross-sectional study explored effect by analyzing concordance several benign GI disorders 525 monozygotic twins compared to that 122 dizygotic aged >20 years from Healthy Twin Study data Genome Epidemiology (2005-2014). Chi-square test, Wilcoxon...
Microarray data includes tens of thousands gene expressions simultaneously, so it can be effectively used in identifying the phenotypes diseases. However, retrieval functional information from a large corpus expression is still time-consuming task. In this paper, we propose an efficient method for categories differentially expressed genes micro-array experiment by using Gene Ontology (GO). Our as follows: (1) The set first filtered to include only with mean values that differ at least 3-fold...
We established reference intervals for research parameters of complete blood cell count and examined their usefulness diagnosing certain diseases.Reference 26 basic 38 were 3,457 1,325 men 2,742 830 women aged 20 - 59 ≥ 60 years, respectively. Research parameter values patients with iron deficiency anemia (IDA), appendicitis, sepsis, myelodysplastic syndromes (MDS) compared against gender- age-matched values.Seven 10 among one required partitioning by age. No gender was required. Further,...
Background:The ASXL1 codon 646 variant is the most common that negatively impacts prognoses of patients with myeloid malignancies, particularly those myelodysplastic syndromes and acute leukemia.However, it has been suggested this mutation not somatic but rather an artifact next-generation sequencing (NGS) owing to its location in 8 bp guanine mononucleotide repeat.In study, we evaluated performance amplicon-based NGS discriminating variant.Methods: Amplicon-based was performed on Myeloid...