A5004228370- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Liver Disease and Transplantation
- Intensive Care Unit Cognitive Disorders
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Vascular Anomalies and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Ion channel regulation and function
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Pneumonia and Respiratory Infections
Chung-Ang University Hospital
2024
University of Ulsan
2009-2023
Ulsan College
2009-2023
Gangneung Asan Hospital
2018-2023
Asan Medical Center
2016-2017
Eulji University
2007-2016
Eulji University Hospital
2015-2016
Konyang University
2013
Lymphovascular invasion (LVI) is one of the most important prognostic factors in gastric cancer as it indicates a higher likelihood lymph node metastasis and poorer overall outcome for patient. Despite its importance, detection LVI(+) histopathology specimens can be challenging task pathologists subtle difficult to discern. Herein, we propose deep learning-based method using H&E-stained whole-slide images. The ConViT model showed best performance terms both AUROC AURPC among...
Abstract Diffuse large B‐cell lymphoma (DLBCL) is a heterogeneous and prevalent subtype of aggressive non‐Hodgkin that poses diagnostic prognostic challenges, particularly in predicting drug responsiveness. In this study, we used digital pathology deep learning to predict responses immunochemotherapy patients with DLBCL. We retrospectively collected 251 slide images from 216 DLBCL treated rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R‐CHOP), their response labels. The...
Spontaneous isolated dissection of the superior mesenteric artery (SMA) is uncommon. Because its rarity, risk factors, aetiology and natural history are unclear, there no consensus on optimal treatment strategy.Seven consecutive patients with symptomatic spontaneous SMA who received conservative between March 2003 February 2008 were included in this study. Their clinical characteristics, methods outcomes analysed retrospectively.Acute abdominal pain was most common manifestation. Initial...
High expression of glucose transporter family members, which augment uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation survival tumor cells, contributing energy supply, biosynthesis homeostasis cancer cells. Among many solute carrier 2 member 1 (SLC2A1) encodes transporter, GLUT1, that is critical metabolism glucose, an source for cell growth contributes progression development. The aim this study was analyze genetic changes/immune profiles patients with...
Background/Aims We compared the cirrhosis-prediction accuracy of an ultrasonographic scoring system (USSS) combining six representative sonographic indices with that liver stiffness measurement (LSM) by transient elastography, and prospectively investigated correlation between USSS score LSM in predicting cirrhosis. Methods Two hundred thirty patients chronic diseases (187 men, 43 women; age, 50.4±9.5 y, mean±SD) were enrolled this prospective study. The produces a combined for nodularity...
Background Matrix metalloproteinase-9 (MMP-9) is associated with remodelling of the extracellular matrix and invasion in various cancers. Identifying proteins connected to high MMP-9 expression important explaining its mechanisms. Our study aims shed light on genes discuss their clinical impact breast cancer. Methods We evaluated 173 cancer cases from Kangbuk Samsung Hospital, 1964 Molecular Taxonomy Breast Cancer International Consortium database serving as a validation cohort. investigated...
Statistical and analytical methods using artificial intelligence approaches such as machine learning (ML) are increasingly being applied to the field of pediatrics, particularly neonatology. This study compared representative ML analysis logistic regression (LR), which is a traditional statistical method, them predict mortality very low birth weight infants (VLBWI). We included 7472 VLBWI data from nationwide Korean neonatal network. Eleven predictor variables (neonatal factors: male sex,...
Abstract The detection of Epstein–Barr virus (EBV) in gastric cancer patients is crucial for clinical decision making, as it related with specific treatment responses and prognoses. Despite its importance, the limited medical resources preclude universal EBV testing. Herein, we propose a deep learning-based prediction method from H&E-stained whole-slide images (WSI). Our model was developed using 319 H&E stained WSI (26 positive; TCGA dataset) Cancer Genome Atlas, 108 (8 ISH an...
Breast cancers are heterogeneous, making it essential to recognise several biomarkers for cancer outcome predictions. Ki67 proliferation index and B cell lymphoma 2 (BCL2) proteins widely used as prognostic indicators in many types of malignancies. While is a marker normal or tumour proliferation, BCL2 plays central role antiproliferative activities. A combination these two with contrary purposes can provide enhanced accuracy than an analysis using single biomarker.We evaluated expression...
Early detection of lung nodules is essential for preventing cancer. However, the number radiologists who can diagnose limited, and considerable effort time are required. To address this problem, researchers investigating automation deep-learning-based nodule detection. deep learning requires large amounts data, which be difficult to collect. Therefore, data collection should optimized facilitate experiments at beginning studies. We collected chest computed tomography scans from 515 patients...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic for mediastinal and hilar lymphadenopathy/mass. This study investigated fever incidence associated risk factors after EBUS-TBNA in 6336 patients who underwent at Asan Medical Center from October 2008 to February 2018. Bronchoscopists evaluated participants’ medical records the 24 h following EBUS-TBNA. Patients were placed either Fever group (n = 665) or non-Fever 5671). developed...
The purpose of this study was to evaluate the risk factors for mechanical ventilation in patients with scrub typhus admitted intensive care unit (ICU) at a university hospital.We retrospectively selected and analyzed clinical data from medical records 70 (32 men, 38 women) ICU between 2004 2014. had mean±standard deviation age 71.2±11.1 years were evaluated two groups: those who been treated (the MV group, n=19) not non-MV n=51). Mean ages group 71.2±8.3 years, respectively.Significant...
70세 남자가 내원 7일전 발생한 우측 흉부 통증, 고열 및 가래를 동반한 기침으로 입원하였다 . 백혈구와 CRP(C reactive protein)의 상승, 방사선 소견상 우하엽에 폐렴을 시사하는 소견이 관찰되어 지역 사회 획득성 폐렴에 준한 경험적 항생제를 투여하였다. 처음 두 번의 연속적인 가래 배양 검사에서 항생제 감수성이 있는 Acinetobacter baumannii 균이 동정 되었으며 치료 후 임상 증상 점차 호전되었다 는 중환자실에서 주로 발생하는 병원 폐렴의 주요 균으로 알려져 있으며 흔한 원인균은 아니다 .(Tuberc Respir Dis 2007; 63: 273-277)Key Words: , Community-acquired pneumonia .Address for correspondence: Dong Jib Na, M.D. Division of Pulmonary Medicine, Department Eulji University School 1036...
We report a case of agranulocytosis caused by ethambutol in 79-year-old man with pulmonary tuberculosis. He was referred for fever and skin rash developed on 21th day after antituberculosis drugs (isoniazid, rifampicin, ethambutol, pyrazinamide) intake. Complete blood count at the time diagnosis tuberculosis normal. On seventh admission day, absolute neutrophil 70/µL. discontinued all drugs, then treated granulocyte colony-stimulating factor. Three days later, number white cell returned to...
Gamma-butyrobetaine dioxygenase (BBOX1) is a catalyst for the conversion of gamma-butyrobetaine to l-carnitine, which detected in normal renal tubules. The purpose this study was analyze prognosis, immune response, and genetic alterations associated with low BBOX1 expression patients clear cell carcinoma (RCC). We analyzed relative influence on survival using machine learning investigated drugs that can inhibit cancer cells expression. clinicopathologic factors, rates, profiles, gene sets...
Ninety percent of patients with scrub typhus (SC) vasculitis-like syndrome recover after mild symptoms; however, 10% can suffer serious complications, such as acute respiratory failure (ARF) and admission to the intensive care unit (ICU). Predictors for progression SC have not yet been established, conventional scoring systems ICU are insufficient predict severity. We aimed identify simple robust indicators aggressive behaviors SC. evaluated 91 81 non-SC who were admitted ICU, 32 cases from...
Abstract The revised criteria of the 8 th American Joint Committee on Cancer (AJCC) cancer staging system consider depth invasion as one factors that determine stage in distal bile duct (DBD) cancer, but exclude adjacent organ invasion. aims were to evaluate association between and relapse-free survival (RFS) overall (OS) after curative surgical resection DBD propose optimal for predicting clinical outcomes. In this retrospective cohort study, 378 patients with treated multi-institutions...
Background: Evaluation of company clinical trial reports could provide information for metaanalysis at the commercial introduction a new technology.Methods: Clinical sildenafil erectile dysfunction from September 1997 were used meta-analysis randomised trials (at least four weeks duration) and using fixed or dose optimisation regimens.The main outcome sought was an erection, sufficiently rigid penetration, followed by successful intercourse, conducted home. Results:Ten controlled fulfilled...
Since IgG4-related pancreatitis was first reported in 2001, disease has been identified other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic chest computed tomography revealed about 4.1 cm irregular shaped mass spiculated margin left upper lobe. Despite no elevation of serum IgG4 level, he finally diagnosed by transthoracic needle biopsy. After treatment oral...
<title>Abstract</title> <bold>Background</bold> This study aimed to evaluate the 1-year mortality rate among older patients with COVID-19 discharged from hospital and identify risk factors associated this outcome. <bold>Methods</bold> Using a dataset Korean National Health Insurance System, study’s evaluation period spanned October 8, 2020, December 31, 2021. The primary outcome was following discharge. A logistic regression model employed for multivariable analysis estimate odds ratios...
This study aimed to evaluate the 1-year mortality rate among older patients with COVID-19 discharged from hospital and identify risk factors associated this outcome. Using a dataset Korean National Health Insurance System, study's evaluation period spanned October 8, 2020, through December 31, 2021. The primary outcome was following discharge. A logistic regression model employed for multivariable analysis estimate odds ratios outcomes, Kaplan-Meier method used analyze differences in...
Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear cytoplasmic MMP-11 expressions were assessed using immunohistochemistry tumor tissue microarray specimens. relationships UTX,...