A5039016648- Bipolar Disorder and Treatment
- Resilience and Mental Health
- Schizophrenia research and treatment
- Synthesis and Reactivity of Heterocycles
- Treatment of Major Depression
- Psychosocial Factors Impacting Youth
- Cyclopropane Reaction Mechanisms
- Suicide and Self-Harm Studies
- Education and Learning Interventions
- Posttraumatic Stress Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Health and Wellbeing Research
- Healthcare Education and Workforce Issues
- Catalytic C–H Functionalization Methods
- Eating Disorders and Behaviors
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Migration, Health and Trauma
- Peptidase Inhibition and Analysis
- Sulfur Compounds in Biology
- Attention Deficit Hyperactivity Disorder
- Grit, Self-Efficacy, and Motivation
- Child Abuse and Trauma
- Redox biology and oxidative stress
Jeju National University
2016-2025
Jeju National University Hospital
2017-2025
St. Vincent's Hospital
2024
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
2022-2023
Keimyung University
2022
Yonsei University
2012-2022
Scripps (United States)
2022
Inje University Busan Paik Hospital
2022
University of Florida
2022
Scripps Research Institute
2018-2021
To evaluate the associations between cyberbullying behaviors and problematic internet use, to compare psychopathologic symptoms in victims, perpetrators, victims-perpetrators of those youths who were not involved cyberbullying.A total 4531 (11-14 years age) recruited from elementary middle schools.Among youths, 9.7% cyberbullying; 3.3% only victims; 3.4% perpetrators; 3.0% victims-perpetrators. Cyberbullying associated with use as well various symptoms.Depressive victimization, rule-breaking...
Abstract Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated signaling at a network level. Here we present comprehensive, quantitative, site-specific profile intrinsic reactivity cysteinome wild-type . We also describe global characterization redoxome which measured three major forms after H 2 O...
Abstract The Connor–Davidson Resilience Scale (CD‐RISC) is a brief self‐rating questionnaire for measuring resilience. aims of the present study were to describe development Korean version CD‐RISC (K‐CD‐RISC) and more firmly establish its psychometric properties in terms reliability validity. participants consisted general population sample ( n = 194) psychiatric outpatients 127) with non‐psychotic mood or anxiety disorders. K‐CD‐RISC score means (standard deviation) 65.9 (13.6) 50.4 (20.5)...
This study evaluated clinical characteristics and suicidality of patients with anxious depression in a large cohort samples. Data were collected from 1003 who depressed. A total 461 diagnosed 542 nonanxious depression. After adjusting for the severity depression, those group had significantly younger onset age, been suffering longer period, more likely to experience recurrence, obtained lower scores on scale assessing quality life. The was characterized by higher proportion individuals...
A highly efficient [4 + 2] annulation route to polysubstituted indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes good excellent yields, leading with various substituents at the 5, 6, and 7 positions depending on reacting active methylene partners.
The ratio of 2nd to 4th digit length (2D:4D) is a sexually dimorphic trait. Men have relatively shorter second than fourth digit. This thought be influenced by higher prenatal testosterone level or greater sensitivity androgen. purpose this study investigate the relationship between alcohol dependence and 2D:4D in Korean sample whether can biologic marker dependence.The present aimed evaluate efficacy low frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over right...
Abstract ‘Turn-on’ fluorescence probes for detecting H 2 O in cells are established, but equivalent tools to monitor the products of its reaction with protein cysteines have not been reported. Here we describe fluorogenic sulfenic acid, a redox modification inextricably linked signaling and oxidative stress. The reagents exhibit excellent cell permeability, rapid reactivity, high selectivity minimal cytotoxicity. We develop high-throughput assay measuring S -sulfenation use it screen curated...
Described herein is a highly efficient total synthesis of brazilin from commercially available starting materials in 9 steps with 70% overall yield. Mitsunobu coupling followed by In(III)-catalyzed alkyne-aldehyde metathesis allowed for rapid construction core skeleton quantitative Subsequent modulation oxidation levels and acid-catalyzed cyclization led to the trimethyl ether brazilin. Asymmetric dihydroxylation key intermediate was also demonstrated, which would permit asymmetric access...
Objectives: The aims of the present study were to assess prevalence bullying victimization among Korean adolescents by sex and age investigate correlates this phenomenon. Methods: Of 3,200 eligible subjects, 2,936 (91.8%) recruited from four elementary schools (6th grade, range: 10–12 years), five middle (8th 13–14 three high (10th 15–17 years) located in Jeju Special Self-Governing Province, Republic Korea. This used a self-administered questionnaire collect data on sociodemographic...
Sulfur dioxide (SO
Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along expected C5-acylated minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead intended alkyne-carbonyl metathesis.
Background: Attention-deficit hyperactivity disorder (ADHD) persists into adulthood in a high proportion of cases, causing social difficulties and affective problems. We evaluated the prevalence symptoms ADHD correlates thereof Korean college students. Methods: A total 2,172 students, stratified to reflect geographical differences, were asked complete self-report questionnaires on symptoms, depression, related factors. Results: found 7.6% Univariate analysis revealed that younger students...
The purpose of this study was to develop and evaluate psychometrically the Korean version Primary Care Posttraumatic Stress Disorder Screen for Diagnostic Statistical Manual-fifth edition (K-PC-PTSD-5). In total, 252 participants were interviewed with Structured Clinical Interview edition-research (SCID-5-RV). K-PC-PTSD-5 showed good internal consistency (α = 0.872), test-retest reliability (r 0.89), concurrent validity 0.81). A score 3 identified as threshold clinically significant...
The aim of this study was to examine the validity Korean version Hypomania Checklist-32, second revision (HCL-32-R2) in mood disorder patients.A total 454 patients who diagnosed as according Structured Clinical Interview for DSM-IV Axis I Disorders, clinician (SCID-CV) (bipolar [BD] I, n=190; BD-II, n=72; and major depressive [MDD], n=192) completed module HCL-32-R2 (KHCL-32-R2).The KHCL-32-R2 showed a three-factorial structure (eigenvalue ＞2) that accounted 43.26% variance. Factor 1 labeled...
Post-functionalization at the C3 position of indolizines <italic>via</italic> In(<sc>iii</sc>)-catalyzed three-component coupling reaction with amines and aldehydes allowed rapid access to a new class diverse functional groups in good excellent yields.