A5101919177- Inflammatory mediators and NSAID effects
- Ubiquitin and proteasome pathways
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Lymphoma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Plant Stress Responses and Tolerance
- Adenosine and Purinergic Signaling
- Click Chemistry and Applications
- Cutaneous lymphoproliferative disorders research
- Peroxisome Proliferator-Activated Receptors
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Lipid metabolism and disorders
- Colorectal Cancer Screening and Detection
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Disease and Adiposity
- Advanced biosensing and bioanalysis techniques
- Medicinal Plants and Bioactive Compounds
- Advanced Proteomics Techniques and Applications
- Cardiac tumors and thrombi
- Plant nutrient uptake and metabolism
- Retinoids in leukemia and cellular processes
- Toxin Mechanisms and Immunotoxins
- Urticaria and Related Conditions
Peking University
2023-2024
Peking University First Hospital
2023-2024
Beijing Proteome Research Center
2020-2022
Anhui Medical University
2020-2022
Chinese People's Armed Police Force
2020
Logistics University of People's Armed Police Force
2020
Local Initiatives Support Corporation
2009
New York City College of Technology
2004-2008
Zero to Three
2004
City University of New York
2004
Click chemistry─specifically the copper-catalyzed azide-alkyne cycloaddition─has enabled development of a wide range chemical probes to analyze subsets functional proteome. The "clickable" proteome can be selectively enriched by using diverse cleavable biotin tags, but direct identification probe/tag-modified peptides (or peptide-centric analysis) remains challenging. Here, we evaluated performance five commercially available tags in three most common chemoproteomic workflows, resulting...
Sulfur dioxide (SO
Objectives Mast cell (MC) degranulation is a key process in allergic reactions and inflammatory responses. Aspartate aminotransferase 1 (AAT1)-derived endogenous sulfur dioxide (SO 2 ) an important regulator of MC function. However, the mechanism underlying its role remains unclear. This study aimed to investigate by which SO controlled degranulation. Methods HMC-1 Rat basophilic leukemia line (RBL-2H3) were used experiments. content was detected situ fluorescent probe. represented release...
Abstract Accumulation of ubiquitinated proteins in inclusions is common to various neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis, although it occurs selective neurons each disease. The mechanisms generating abnormal aggregates their role neurodegeneration remain unclear. Inclusions appear familial non‐familial cases disorders, suggesting that factors other than particular mutations contribute protein accumulation aggregation....
Gasotransmitters, including nitric oxide (NO), hydrogen sulfide (H
Abstract The role of the proinflammatory and inducible form cyclooxygenases (COX‐2) in neurodegeneration is not well defined. Some its metabolic products, such as prostaglandins (PG) J2 series, are known to be neurotoxic. Here we demonstrate that PGJ2 enhances COX‐2 gene expression without elevating COX‐1 levels neuronal cells. also increased PGE2 production, establishing de novo synthesized enzymatically active. derivatives, 15d‐PGJ2, activators PPARγ, a nuclear receptor activates...
Gasotransmitter-mediated cysteine post-translational modifications, including S-nitrosylation (SNO) and S-persulfidation (SSH), play crucial roles interact in various biological processes. However, there has been a delay appreciating the interactional rules between SNO SSH. Here, all human S-nitrosylated S-persulfidated proteomic data were curated, comprehensive analyses from multiple perspectives, sequence, structure, function, exact protein impacts (e.g., up-/down-regulation), performed....
Most patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role pathogenesis SCRC. In this study, we assessed microbial composition and diversity SCRC tumors varying MutL protein homolog 1 (MLH1) status, effects functional genes related to bacterial markers clinical diagnostic prediction.The tumor were profiled using high-throughput sequencing 16S ribosomal RNA (rRNA) gene V4...
Objective To investigate the feature, pathological diagnosis and differential of blastic plasmacytoid dendritic cell neoplasm(BPDCN). Methods The clinical histological findings, immunophenotype, treatment prognosis one case with BPDCN were evaluated review relevant literature. Results The female patient age 32 years presented as cutaneous lesions. Pathologic findings showed skin bone marrow involved. Microscopically, tumors composed diffuse blasts small to medium size, scant...
Objective To analyze the clinical value of immunohistochemical staining Helicobacter pylori (Hp) in patients with idiopathic thrombocytopenic purpura (ITP). Methods A total 79 ITP were performed gastroscopy and biopsy gastric mucosa. Hematoxylin eosin (HE) performed. Before gastroscopy, 14C-urea breath test was used to detect Hp infection. Results The positive rates infection detected by cases 51.9 % (41/79) 67.1 (53/79) respectively, difference statistically significant (χ 2 =...
目的 探讨原发性脾弥漫大B细胞淋巴瘤(DLBCL)的临床病理学特征及治疗策略。 方法 回顾性分析1例原发性脾DLBCL患者的临床资料及病理切片，并复习相关文献。 结果 ，无发热及浅表淋巴结肿大，CT证实脾多发占位性病变伴脾门多发肿大淋巴结。行脾、胰尾切除术，病理确诊为DLBCL，免疫分型为生发中心B细胞型。外周血和骨髓检查结果正常。脾切除术后给予联合化疗，随访1年处于完全缓解期。 结论 原发性脾DLBCL罕见，患者早期无明显症状，手术探查是早期诊断的首选方法，病理学检查是诊断金标准。治疗首选脾切除术，术后辅助化疗及放疗可以提高患者生存率。
The objective of this study is to investigate the cell signaling pathway that leads COX-2 upregulation in stressed neuronal cells. Here we demonstrate neurotoxic prostaglandins (PG) J2 series enhance gene expression without elevating COX-1 levels PGJ2 also increased PGE2 production, establishing de novo synthesized enzymatically active. selective PPARγ agonist ciglitazone failed up-regulate COX-2, indicating effect on independent. Furthermore, stabilized IκBα levels, NFκB not active under...
目的 探讨原发于前列腺的血管内大B细胞淋巴瘤（IVLBCL）的临床病理特征、诊断、鉴别诊断、治疗及预后。 方法 回顾性分析1例前列腺的IVLBCL患者的临床资料、组织病理学形态和免疫组织化学结果，并复习相关文献。 结果 患者以头晕为首发症状，伴随排尿费力，体检有前列腺肥大，病理活组织检查发现前列腺间质小血管内见成簇异形淋巴样细胞。免疫组织化学示肿瘤细胞CD20+、LCA+、CD79a+、PAX5+、Ki-67阳性率90%，血管内皮CD34+。病理学诊断：前列腺的IVLBCL（活化B细胞起源）。患者拒绝治疗，于诊断后5个月死亡。 结论 原发于前列腺的IVLBCL罕见，临床表现缺乏特异性，病理学检查及免疫组织化学对IVLBCL的诊断和鉴别诊断具有重要意义。
目的 探讨眼睑黏膜相关性淋巴组织结外边缘区B细胞淋巴瘤（MALT淋巴瘤）的临床病理特征、诊断与鉴别诊断、治疗及预后。 方法 回顾性分析哈尔滨市第一医院2例眼睑MALT淋巴瘤的临床资料、组织病理学形态和免疫组织化学结果，并复习文献。 结果 2例患者以眼睑肿物为首发症状，均在局部麻醉下完成眼睑肿物切除术，病理检查示肿瘤细胞形态较一致，中等大小，胞质丰富，呈弥漫性或结节状排列，诊断为眼睑MALT淋巴瘤。免疫组织化学示2例患者肿瘤细胞均CD20（+），CD79a（+），CD3（-），CD10（-），bcl-6（-），CD5（-），cyclin D1（-），CK（-）。 结论 眼睑MALT淋巴瘤临床表现缺乏特异性，病因与感染有关，目前尚无一致的治疗方案，要避免过度治疗；病理学检查及免疫组织化学对该病的诊断和鉴别诊断具有重要意义。