A5033497327- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Head and Neck Surgical Oncology
- Esophageal Cancer Research and Treatment
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Sepsis Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
- Medical Imaging and Analysis
- Cerebrovascular and Carotid Artery Diseases
- CAR-T cell therapy research
- Metastasis and carcinoma case studies
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2017-2024
Shanxi Provincial Cancer Hospital
2018-2024
General Hospital of Central Theater Command
2023-2024
Central Hospital of Wuhan
2024
Second Military Medical University
2011-2023
Sun Yat-sen University
1994-2023
Nanjing Medical University
2023
Wuhan General Hospital of Guangzhou
2023
Hebei Medical University
2023
Lateral lumbar interbody fusion (LLIF) is a popular, minimally invasive technique that used to address challenging multilevel degenerative spinal diseases. It remains controversial whether supplemental instrumentation should be added for LLIF. In this study, we compared the kinematic stability afforded by stand-alone lateral cages with those supplemented bilateral pedicle screws and rods (PSR), unilateral PSR, or plate (LP) fixation using finite-element (FE) model of multi-level LLIF...
Abstract Background Tracheal, bronchus, and lung cancer (TBL) is one of the main health problems worldwide, but data on burden trends early‐onset tracheal, (EO‐TBL) are sparse. The aim present study was to provide latest most comprehensive estimates EO‐TBL from 1990 2019. Methods Overall, we used Global Burden Disease (GBD) in Evaluation metrics included incidence, mortality, disability‐adjusted life years (DALYs). joinpoint regression model analyze temporal trends. Decomposition analysis...
A novel electrospun-aligned nanoyarn/three-dimensional porous nanofibrous hybrid scaffold for annulus fibrosus tissue engineering Jun Ma,1,* Yunfei He,1,2,* Xilin Liu,1,* Weiming Chen,3 An Wang,1,4 Chia-Ying Lin,5,6 Xiumei Mo,3 Xiaojian Ye1 1Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, 2Department Spinal Surgery, Lanzhou General Hospital Command Region, Lanzhou, 3College Chemistry, Chemical Engineering and Biotechnology, Donghua 4Department...
The impact of combining plasma fibrinogen levels with Epstein–Barr Virus DNA (EBV DNA) on the prognosis for patients nasopharyngeal carcinoma (NPC) was evaluated. In this observational study, 2563 non-metastatic NPC were evaluated effects circulating and EBV disease-free survival (DFS), distant metastasis-free (DMFS), overall (OS). Compared bottom biomarker tertiles, TNM stage-adjusted hazard ratios (HR, 95% confidence intervals (CIs)) predicting DFS in tertiles 2 to 3 1.26 (1.00 1.60) 1.81...
Objective . Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated hypothesis that preconditioning (HP) could improve therapeutic bone mesenchymal stem cells (BMSCs) to IVD degeneration. Methods. BMSCs from green fluorescent protein-transgenic rats were pretreated with cobalt chloride (CoCl 2 , 100 μ M, 24 h) for conditions vitro Apoptosis (related pathways caspase-3 bcl-2) migration HIF-1 α...
Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists costimulatory receptors cancer therapeutics has largely failed. We sought address this problem using a new class modular synthetic drugs, termed tumor-targeted cell (TICAs), based on constrained bicyclic peptides ( Bicycles ). Methods Phage libraries displaying were panned for binders against tumor necrosis factor (TNF) superfamily CD137 and OX40, antigens EphA2, Nectin-4 programmed death ligand 1. The...
The present study aimed to explore surgical treatments and assess the effects based on features of cervical spine fracture in patients with ankylosing spondylitis (AS) summarize experiences perioperative management. Retrospective analysis was performed 25 AS treated our hospital from January 2011 December 2013. were divided according segments, including 4 cases at C4 C5, 8 C5 C6, 13 C6 C7. Among them, 12 belonged I type, 5 II III type improved classification method for fracture. Subaxial...
Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal deformity. The etiology and pathology of AIS remain unexplained, have been reported to involve a combination genetic epigenetic factors. Since paravertebral muscle imbalance plays an important role in onset progression scoliosis, we aimed investigate transcriptomic differences by RNA-seq identify significantly differentially expressed transcripts two sides AIS.RNA-seq was performed on 5 pairs from patients....
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related microRNAs and DNA methylation modifications has yet to be established. Thus, we aimed identify epigenetic changes in establish the between miRNAs methylation. The mRNA, miRNA, expression profiles of healthy or osteoarthritis samples were downloaded from Gene Expression Omnibus (GEO) database, including GSE169077, GSE175961, GSE162484....
Abstract Background: Optimal adjuvant chemotherapy after laparoscopic surgery in gastric cancer (GC) patients is still undefined. We aimed to evaluate the efficacy of S‐1 plus oxaliplatin (SOX) and capecitabine (CAPOX) with GC gastrectomy. Methods: A non‐inferiority randomized controlled clinical trial was performed China. Patients advanced who underwent D2 gastrectomy were randomly assigned receive SOX CAPOX regimens. Results: In total, 191 screened between May 2018 June 2019, 140 (73.3%)...
Many studies have shown that in the context of public health emergencies, incidence rate adolescent non-suicidal self-injury (NSSI) patients increased dramatically. This paper aims to characterize behavioral characteristics NSSI and analyze influencing factors behavior addiction characteristics.Our research was a case-control study which included 84 adolescents with (female vs. male: 59 25) healthy controls 53 31). All participants enrolled were aged 12-18 years. The differences scores...
Purpose This study aimed to develop and validate a scoring system based on nomogram of common clinical metrics discriminate between active pulmonary tuberculosis (APTB) inactive (IPTB). Patients methods A total 1096 patients with (PTB) admitted Wuhan Jinyintan Hospital January 2017 December 2019 were included in this study. Of these PTB, 744 the training cohort (70%; 458 APTB, 286 IPTB), 352 validation (30%; 220 132 IPTB). Data from used establish diagnostic model. Routine blood examination...
Alveolar and interstitial fibrin deposition is a prominent pathologic feature in many acute lung injury syndromes. Previous studies have suggested that ischemic preservation has stimulatory effect on donor alveolar macrophages (Mphis) during transplantation. An animal model of was developed to examine the hypothesis ischemia enhances Mphi procoagulant activity (PCA) as potential mechanism contributing reperfusion injury. Histologic examination lungs reperfused ex vivo revealed evidence...
Gastric cancer (GC) is a fatal malignancy with high rate of recurrence and metastasis. Here, we investigated the correlations between expression autophagic protein LC3B 2 epithelial-mesenchymal transition-related proteins (E-cadherin Vimentin) clinicopathological factors prognosis patients GC.The LC3B, E-cadherin, Vimentin in GC samples (110 cases) paracarcinoma tissues (40 was analyzed using Oncomine databases further detected by immunohistochemistry. The among these markers features were...
Abstract Lumbosacral nerve root avulsion leads to widespread death of neurons in the anterior horn area injured spinal cord, which results dysfunction lower extremities. Heat shock protein 27 (Hsp27) has been found play cytoprotective roles under adverse conditions. However, role Hsp27 after lumbosacral is unknown. The aim present study was investigate effects and mechanism action on avulsion. It that expression elevated cord up-regulation protected against apoptosis In addition, plays an...