A5100455866- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Sports injuries and prevention
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Inflammatory mediators and NSAID effects
- Lower Extremity Biomechanics and Pathologies
- Adhesion, Friction, and Surface Interactions
- Connective tissue disorders research
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Periodontal Regeneration and Treatments
- Nerve Injury and Rehabilitation
- Congenital Diaphragmatic Hernia Studies
- Venous Thromboembolism Diagnosis and Management
- Oral microbiology and periodontitis research
Third Hospital of Hebei Medical University
2015-2024
Hebei Medical University
2015-2024
Children's Hospital of Capital Institute of Pediatrics
2024
Creative Commons
2021
421 Hospital of PLA
2014
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related microRNAs and DNA methylation modifications has yet to be established. Thus, we aimed identify epigenetic changes in establish the between miRNAs methylation. The mRNA, miRNA, expression profiles of healthy or osteoarthritis samples were downloaded from Gene Expression Omnibus (GEO) database, including GSE169077, GSE175961, GSE162484....
Abstract This article compares the long-term outcomes of closing-wedge osteotomy (CWO) and opening-wedge (OWO) in treatment unicompartmental medial osteoarthritis with varus deformity. study included 79 patients who underwent high tibial (HTO) between 2002 2008. Pre- postoperative radiography computed tomography were used to evaluate posterior slope, patellar height, tibiofemoral angle, lateral joint space. severity arthritis was assessed Kellgren–Lawrence grading system. American Knee...
In the recent decade, there has been substantial progress in technologies and philosophies associated with diagnosing treating anterior cruciate ligament (ACL) injuries China. The therapeutic efficacy of ACL reconstruction re-establishing stability knee joint garnered widespread acknowledgment. However, path toward standardizing diagnostic treatment protocols remains to be further developed refined.
Osteoarthritis (OA) is a non‑inflammatory degenerative joint disease, characterized by pain and stiffness. The prevalence of OA increases with age. However, the relationship between biomarkers [collagen type III α1 (COL3A1), COL5A1, COL6A2, COL12A1] remains unclear. subchondral bone dataset GSE51588 was downloaded from GEO database, differentially expressed genes (DEGs) were screened. Weighted gene co‑expression network analysis performed, protein‑protein interaction constructed further...
Objective To compare the biomechanical and histological changes in a rabbit model after reconstructing anterior cruciate ligament (ACL) with solely autologous tendon combined advanced reinforcement system (LARS) artificial ligament. Methods Anterior reconstruction was performed 72 knees from 36 healthy New Zealand white rabbits (bodyweight, 2500–3000 g). The Achilles tendons were harvested bilaterally. left ACL reconstructed autografts (autologous group), while right LARS ligaments (combined...
Abstract Background Lowering the exit position of tibial tunnel can improve clinical efficacy posterior cruciate ligament (PCL) reconstruction, however, there is no unified positioning standard. This study aimed to use novel soft tissue landmarks create a low tunnel. Methods A total 14 human cadaveric knees and 12 patients with PCL injury were included in this study. Firstly, we observed anatomical between PCL, septum, other tissue, evaluated relationship center (SP tunnel) septum distal...
There are many growth factors contributing to fracture healing after bone fractures. Platelet-derived factor (PDGF) released from platelets is a promoting cell division and proliferation, first appears around the sites of Culture chondrocytes in vitro stimulated by PDGF its presence being upregulated extracellular matrix cartilage; main components include aggrecan type II collagen. induces expression G protein-coupled receptor kinase interacting protein 1 (GIT1), Rac1 ERK1/2 phosphorylation....
Abstract The current study was conducted for investigating the mechanism by which GIT2 gene deletion affects functional recovery and chondrocyte differentiation in rats with rheumatoid arthritis (RA). Thirty‐two were randomly divided into normal, model, knockout (GIT2‐KO), model + GIT2‐KO groups. Hematoxylin‐eosin (HE) staining performed observation of synovial tissues. Immunohistochemistry examinations to determine type II collagen expression as well identify differentiation. qRT‐PCR...
The purpose of this study was to evaluate and compare knee kinematics stability following either triangular or anatomical reconstruction the superficial medial collateral ligament (sMCL) posterior oblique (POL). In a cadaveric model (12 knees), two experimental sMCL POL reconstructions were compared in sMCL- POL-deficient knees versus normal knees. first POL, while second involved an POL. All tested through four different states. changes valgus angles, external rotation, internal rotation...
The purpose of this study was to evaluate the diagnostic value patellar tendon wavy (PTW) sign for an anterior cruciate ligament (ACL) tear on MRI.One hundred MRI scans were prospectively analyzed, with 50 patients ACL underwent reconstruction (group 1) and knee complaints other than 2). PTW confirmed sagittal MRI. In addition, length, tibial-femoral angle tibial translation (TAT) compared between groups.The present in 41/50 (82%) group 1 10/50 (20%) 2, significant difference two groups (p =...
To the Editor: Significant hyperfibrinolysis is always accompanied by surgical trauma and tourniquet use in total knee arthroplasty (TKA), leading to considerable hidden blood loss, inflammation, pain, thereby impeding recovery process. Enhanced after surgery (ERAS) has promoted development of patient management recent decades. And numerous methods conservation, including tranexamic acid (TXA), a lysine analog competitive inhibitor plasmin plasminogen, have been studied.[1–3] However, some...
The 5-methylcytosine (m5C) is a common post-transcriptional RNA methylation modification and involved in the pathological process of many diseases. However, little known about role m5C osteoarthritis (OA). OA gene data corresponding information were downloaded from Gene Expression Omnibus database. Based on 36 regulators, we constructed landscape diagnostic model for OA. Later, two patterns identified, functional analyses performed to evaluate whether these related endoplasmic reticulum (ER)...
This study aims to address the timing of repair for severe congenital diaphragmatic hernia (CDH) without use extracorporeal membrane oxygenation (ECMO) and determine feasibility an earlier intervention avoid deaths associated with non-repair in patients who are more challenging stabilize ECMO. single-center retrospective was conducted on neonates CDH from 2013 2023. Based surgery, were classified into three groups: <24 hours (group A), 24-48 B) ≥48 C). The 90-day survival rates analyzed...
Common peroneal nerve palsy (CPNP) is a rare but serious complication following primary total knee arthroplasty (TKA). The common one of the main molecules sciatic nerve. CPNP series symptoms caused by injury due to paralysis and atrophy fibula tibia muscles. clinical are: ankle joint unable extend back, toe foot droop, walking in steppage gait, dorsal skin sensation having decreased or disappeared. If treatment not timely, severe cases may result anterior lateral calf risk factors for...