A5100386142- Osteoarthritis Treatment and Mechanisms
- Selenium in Biological Systems
- Mesenchymal stem cell research
- Food composition and properties
- Bone Metabolism and Diseases
- Trace Elements in Health
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Bone health and treatments
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Shoulder Injury and Treatment
- Nutritional Studies and Diet
- Orthopedic Infections and Treatments
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Bone Tumor Diagnosis and Treatments
- Hip disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Total Knee Arthroplasty Outcomes
- Proteoglycans and glycosaminoglycans research
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
Xi'an Jiaotong University
2012-2025
Jiangxi Maternal and Child Health Hospital
2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Shanghai Skin Disease Hospital
2025
Tongji University
2025
National Health and Family Planning Commission
2017-2024
Jinan Central Hospital
2019-2024
Xuzhou Medical College
2023-2024
Sun Yat-sen University
2020-2024
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve ESCC were randomized (1:1) to receive toripalimab or placebo in combination paclitaxel plus cisplatin (TP) every weeks up 6 cycles, followed by maintenance. At prespecified final analysis of progression-free survival (PFS), a significant improvement PFS observed arm over (hazard ratio...
Summary Primary osteoarthritis ( OA ) is associated with aging, while post‐traumatic PTOA mechanical injury and inflammation. It not clear whether the two types of share common mechanisms. We found that miR‐146a, a micro RNA ‐associated inflammation, activated by cyclic load in physiological range but suppressed overload human articular chondrocytes. Furthermore, miR‐146a expression decreased lesions cartilage. To understand role osteoarthritis, we systemically characterized mice which...
Chordomas are rare malignant tumors that originate from the notochord remnants and occur in skull base, spine sacrum. Due to a very limited understanding of molecular pathogenesis chordoma, there no adjuvant therapies besides surgical resection radiation therapy. microRNAs (miRNAs) small noncoding regulatory RNA molecules with critical roles cancer. The role miRNAs chordomas is mostly unknown. We uncover microRNA-608 (miR-608) microRNA-34a (miR-34a) as novel tumor suppressive regulate...
Background and purpose Trauma-induced osteonecrosis of the femoral head (TIONFH) is a major complication neck fractures. Degeneration necrosis subchondral bone can cause collapse, which results in hip joint dysfunction patients. The destruction metabolism homeostasis an important factor for osteonecrosis. MicroRNAs (miRNAs) have role regulating osteogenic differentiation, but mechanisms underlying abnormal TIONFH are poorly understood. In this study, we screened specific miRNAs by microarray...
A risk score identifying patients at high for veno-occlusive disease (VOD) may aid efforts to study preventive strategies this uncommon complication of hematopoietic cell transplantation (HCT). Patients receiving a first allogeneic HCT between 2008 and 2013 as reported the Center International Blood Marrow Transplant Research (N = 13,097) were randomly divided into training validation sets. Independent prognostic factors development VOD by day +100 after identified with multivariate logistic...
Bone marrow mesenchymal stem cells (BMSCs)-based engineered cartilage usually faces the significant challenge of endochondral ossification tendency in an ectopic environment because inevitable vascular infiltration during chondrogenic differentiation and developmental stages. Additionally, current scaffold-free BMSC regeneration requires a long vitro preinduction time for before vivo transplantation, which limits its application multiple defect repair. Therefore, ideal cell-based needs to...
A growing number of studies are reporting beneficial effects the transplantation alleged cardiac stem cells into diseased hearts after myocardial infarction. However, mechanisms by which transplanted might help to promote repair tissue not understood and involve processes different from differentiation cardiomyocytes. We have compared exerted skeletal myoblasts (which able form new cardiomyocytes) ESC-derived cardiomyocytes implantation infarcted mouse echocardiographic follow-up...
Sirtuin1 (SIRT1) has recently emerged as a pivotal regulator of glucose metabolism and insulin sensitivity. However, the underlying mechanism not been fully elucidated. In this study, we investigated role SIRT1 in development obesity resistance by generating mice with adipose-specific ablation Sirt1 (Ad-Sirt1-/- mice). Ad-Sirt1-/- exhibited increased fat mass, impaired tolerance, attenuated sensitivity, exosomes, whereas administration exosomes inhibitor effectively ameliorated metabolic...
Magnesium ions (Mg2+) play an important role in promoting cartilage repair lesions. However, no research has focused on the of Mg2+ combined with microfracture (MFX) hyaline-like mediated by injury. This study aimed to investigate beneficial effects combination MFX and repair. A total 60 rabbits were classified into five groups (n = 12 each): sham, MFX, three different doses treatment (0.05, 0.5, 5 mol/L). Bone defects created trochlear groove rabbits. surgery was performed after...
Background Polycystic ovary syndrome (PCOS) is an endocrine disorders and characterized by polycystic morphology oligomenorrhea, affecting fertility health condition of female around the world. The causative factors PCOS are complex, genetic structure remains a long-standing medical challenge in genetics. Previous genome-wide association study (GWAS) showed that Wing-less-related integration site (Wnt) signaling most affected pathway among PCOS-related risk genes, mutations Wnt/β-catenin may...
Waldenström macroglobulinemia (WM) is a rare hematological disorder with an annual incidence of about 3 per million. Its clinical manifestations are diverse and non - specific, approximately 30% patients asymptomatic, making early diagnosis challenging. This paper reports 73-year-old female who was admitted to the hospital due atrial fibrillation. During physical examination several years before hospitalization, elevated CA19-9 detected, but cause remained unclear after multiple outpatient...
Clinical treatment of cartilage defects is challenging due to concomitant post-traumatic joint inflammation. This study was demonstrate that the antioxidant ability human adult synovium-derived stem cells (SDSCs) could be enhanced by ex vivo expansion on a decellularized cell matrix (DSCM). Microarray used evaluate oxidative, antioxidative, and chondrogenic status in SDSCs after DSCM induction medium. Hydrogen peroxide (H2O2) added create oxidative stress either expanded or chondrogenically...