A5100643696- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Musculoskeletal synovial abnormalities and treatments
- Sports injuries and prevention
- Shoulder and Clavicle Injuries
- Osteoarthritis Treatment and Mechanisms
- Cardiac Valve Diseases and Treatments
- Crystal structures of chemical compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Lower Extremity Biomechanics and Pathologies
- Quantum Information and Cryptography
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Synthesis and Characterization of Heterocyclic Compounds
- CRISPR and Genetic Engineering
- Spaceflight effects on biology
- Chromosomal and Genetic Variations
Peking University
2014-2025
Peking University Third Hospital
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Beijing Sport University
2024-2025
Beijing Haidian Hospital
2022-2025
China Astronaut Research and Training Center
2017-2024
University of Jinan
2024
Shandong Agricultural University
2021-2024
Harbin Institute of Technology
2024
China Medical University
2023
Abstract Degradation of extracellular matrix (ECM) underlies loss cartilage tissue in osteoarthritis, a common disease for which no effective disease-modifying therapy currently exists. Here we describe BNTA, small molecule with ECM modulatory properties. BNTA promotes generation components cultured chondrocytes isolated from individuals osteoarthritis. In human osteoarthritic explants, treatment stimulates expression while suppressing inflammatory mediators. Intra-articular injection delays...
The regeneration of osteochondral tissue necessitates the re-establishment a gradient owing to unique characteristics and healing potential chondral osseous phases. As self-healing capacity hyaline cartilage is limited, timely mechanical support during neo-cartilage formation crucial achieving optimal repair efficacy. In this study, we devised biodegradable bilayered scaffold, comprising chondroitin sulfate (CS) hydrogel regenerate porous pure zinc (Zn) scaffold for underlying bone as layer....
Abstract Increasing evidence suggests that oxidative damage is associated with normal aging and several neurodegenerative diseases. Mild cognitive impairment (MCI), the phase between early dementia, a common problem in elderly many subjects going on to develop Alzheimer's disease (AD). Although increased DNA oxidation observed AD brain, it unclear when begins. To determine if occurs brain of MCI, we quantified multiple oxidized bases nuclear mitochondrial isolated from frontal, parietal...
Lin28 acts as a repressor of microRNA processing and post-transcriptional regulatory factor for subset mRNAs. Here we report that in human embryonic stem cells facilitates the expression pivotal pluripotency Oct4 at level. We provide evidence binds mRNA directly through high affinity sites within its coding region an interaction between RNA helicase A (RHA) may play part observed regulation. further demonstrate decreasing RHA levels impairs Lin28-dependent stimulation translation reporter...
The nuage is a germline-specific perinuclear structure that remains functionally elusive. Recently, the in Drosophila was shown to contain two of three PIWI proteins - Aubergine and Argonaute 3 (AGO3) are essential for germline development. bind PIWI-interacting RNAs (piRNAs) function epigenetic regulation transposon control. Here, we report novel component, PAPI (Partner PIWIs), contains TUDOR domain interacts with all via symmetrically dimethylated arginine residues their N-terminal...
In the Internet Age, optical networks are vulnerable to numerous cyberattacks, and conventional key distribution methods suffer from increased computational power. QKD can distribute information-theoretically secure secret keys between two parties based on principles of quantum mechanics. Integrating into leverage existing fiber infrastructures with wavelength division multiplexing for practical deployment keys, accordingly employ optical-layer security enhancement. Then, how efficiently...
Osteochondral defects pose a great challenge and satisfactory strategy for their repair has yet to be identified. In particular, poor could result in the generation of fibrous cartilage subchondral bone, causing degeneration osteochondral tissue eventually leading failure. Herein, taking inspiration from chemical elements inherent natural extracellular matrix (ECM), we proposed novel ECM-mimicking scaffold composed polysaccharides polypeptides repair. By meticulously modifying biopolymers...
Osteoarthritis is a serious disease affecting joint cartilage. Owing to poor blood supply, the meniscus and acetabular labrum of joints heal poorly after injury. However, development artificial alternatives these components that have similar mechanical properties cartilage-protection ability challenging. In this study, strong hydrogel with biomimetic microstructure prepared an emulsion-type photosensitive resin, where both hydrophilic hydrophobic monomers, photo-initiator, drugs can be...
Reduced graft failure rates have been reported after anterior cruciate ligament (ACL) reconstruction combined with anterolateral complex (ALC) augmentation. However, the preoperative diagnosis of concomitant ALC injury remains a clinical challenge.
Quantum key distribution (QKD) uses the laws of quantum mechanics to distribute secret keys with information-theoretic security. To realize QKD for secure communications among multiple distant users, fiber-based networks can be deployed today's available technologies. Incorporating into existing wavelength-division multiplexing (WDM) network infrastructure provides a practical way reduce difficulty and cost networking. Nonetheless, costs nodes links are still considered as major barriers...
Discoid lateral meniscus (DLM) is the most common congenital variant of meniscus, which prone to degeneration and lesions, often leads knee osteoarthritis. At present, there no consensus on clinical practice DLM, this expert guidelines DLM was developed approved by Chinese Society Sports Medicine according Delphi method. Among 32 statements drafted, 14 were excluded for redundant information, 18 achieved consensus. This focused definition, epidemiology, etiology, classification,...