A5053089929- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Foot and Ankle Surgery
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Tendon Structure and Treatment
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Sports Performance and Training
- Bone fractures and treatments
- Bone health and treatments
- Adipose Tissue and Metabolism
- Musculoskeletal synovial abnormalities and treatments
- Occupational Health and Performance
- Cancer-related gene regulation
- Bone Tissue Engineering Materials
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Dental Implant Techniques and Outcomes
- RNA modifications and cancer
Third Hospital of Hebei Medical University
2016-2025
Hebei Medical University
2016-2025
Hospital for Special Surgery
2019-2024
Clinical Orthopaedics and Related Research
2019
Cornell University
2019
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2019
National Institute of Allergy and Infectious Diseases
2019
National Institutes of Health
2019
Aims Current treatments of prosthetic joint infection (PJI) are minimally effective against Staphylococcus aureus biofilm. A murine PJI model debridement, antibiotics, and implant retention (DAIR) was used to test the hypothesis that PlySs2, a bacteriophage-derived lysin, can target S. biofilm address unique challenges presented in this periprosthetic environment. Methods The ability PlySs2 vancomycin kill colony-forming units (CFUs) on orthopaedic implants were compared using vitro models....
Background: Studies have revealed abnormalities of the epiphyseal plate distal femur in patients with trochlear dysplasia, but it is unclear whether could be remodeled after surgical correction patellar dislocation. Purpose: To investigate morphology and trochlea improved medial retinaculum plasty skeletally immature to correlations between dysplasia as well clinical outcomes. Study Design: Cohort study; Level evidence, 3. Methods: Eligible were retrospectively enrolled: 48 dislocation who...
Osteoarthritis (OA) is a joint disease closely associated with synovial tissue inflammation, the severity of synovitis impacting progression. m7G RNA methylation critical in processing, metabolism, and function, but its role OA not well understood. This study explores relationship between immune infiltration OA. Data were obtained from GEO database. Hub genes related to identified using differential expression LASSO-Cox regression analysis, diagnostic model was developed. Functional...
Abstract Background Periprosthetic joint infection (PJI) is one of the most devastating complications total arthroplasty. Given mortality and morbidity associated with PJI challenges in treating it, there has been increased interest risk factors that can be modified before surgery. In this study, we used a novel mouse model to consider role gut microbiome as factor for PJI. Questions/purposes (1) Does state microbiota surgery influence likelihood developing an established PJI? (2) How does...
Abstract The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict their nomination of osteoblasts versus osteoclasts the key producers skeletal and additionally offer conflicting data on effects osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable expression during human or mouse osteoclastogenesis only modest SLIT3-mediated osteoclast differentiation. Conditional deletion cathepsin K...
Abstract Background The infrapatellar fat pad (IPFP) lies extrasynovial and intracapsular, preserving the joint cavity serving as a biochemical regulator of inflammatory reactions. However, there is lack research on relationship between anterior knee pain (AKP) IPFP after medial patellofemoral ligament reconstruction (MPFLR). Pinpointing source enables clinicians to promptly manage intervene, facilitating personalized rehabilitation improving patient prognosis. Methods A total 181 patients...
Objective To demonstrate the effect of screw‐home motion on stability patellofemoral joint, and investigate its mechanism regulation patellar tracking. Methods Twenty volunteers who met criteria were examined. All subjects had axial computed tomography ( CT) scanning performed bilateral knees at 0° 30° flexion. Scanning began above femorotibial articulation femoral trochlear groove, moved sequentially down to level anterior tibial tubercle. The following measurements obtained: rotation...
Developmental factors were assumed to be the key that influenced morphology of femoral trochlea. This study investigated effects insufficient patellar stress after birth on morphological development Effects trochlea using surgical induced patellectomy and dislocation in growing rat model. In this study, two experimental groups one sham group (SG) established. Thirty-six Wistar rats (female, 28 days age) randomly assigned three groups. The (PG), underwent group. (DG), surgery-induced...
Abstract Purpose It has been widely reported that femoral anteversion is a risk factor for patellar dislocation. This study aims to evaluate whether internal torsion of the distal femur noticeable in patients without increased and assess it Methods A retrospective analysis was conducted on 35 (24 females, 11 males) with recurrent dislocation but treated our hospital from January 2019 August 2020. All underwent knee X-rays, digital radiography lower-limbs, CT scans hip, knee, ankle joints...
Abstract This article compares the long-term outcomes of closing-wedge osteotomy (CWO) and opening-wedge (OWO) in treatment unicompartmental medial osteoarthritis with varus deformity. study included 79 patients who underwent high tibial (HTO) between 2002 2008. Pre- postoperative radiography computed tomography were used to evaluate posterior slope, patellar height, tibiofemoral angle, lateral joint space. severity arthritis was assessed Kellgren–Lawrence grading system. American Knee...
It is increasingly appreciated that coordinated regulation of angiogenesis and osteogenesis needed for bone formation. How this achieved during peri-implant healing, such as osseointegration, largely unclear. This study examined the relationship between in a unique model osseointegration mouse tibial implant by pharmacologically blocking vascular endothelial growth factor (VEGF) pathway.An was inserted into right tibia 16-week-old female C57BL/6 mice (n = 38). Mice received anti-VEGF...
The shape of the patella has been considered to be a predisposing factor resulting in patellar instability, but effects abnormal position during its development are unclear. present study evaluated morphological changes after instability and influence on shape. Twenty rabbits that were 2 months old included study. left knee each rabbit, defined as experimental group (N = 20 knees/group), underwent medial soft tissue restraint release. right control did not undergo any surgical procedures. A...
Osteoarthritis (OA) is a non‑inflammatory degenerative joint disease, characterized by pain and stiffness. The prevalence of OA increases with age. However, the relationship between biomarkers [collagen type III α1 (COL3A1), COL5A1, COL6A2, COL12A1] remains unclear. subchondral bone dataset GSE51588 was downloaded from GEO database, differentially expressed genes (DEGs) were screened. Weighted gene co‑expression network analysis performed, protein‑protein interaction constructed further...
Abstract Administration of bisphosphonates following total joint arthroplasty might be beneficial to reduce aseptic loosening. However, their effects on peri‐implant bone formation and bone–implant interface strength have not been investigated yet. We used a physiologically loaded mouse implant model investigate the short‐term postoperative systemic alendronate osseointegration. A titanium with rough surface was inserted in proximal tibiae 17‐week‐old female C57BL/6 mice ( n = 44)....
Abstract Background Whether vastus medialis obliquus atrophy exists in patients with patellofemoral pain syndrome and whether the amount of differs between lateralis muscles remain unknown. Materials From June 2016 to March 2019, 61 were retrospectively included study group, an age-, sex-, body mass index-matched cohort normal knees was randomly selected as control group. All enrolled subjects had undergone CT scans supine position. The cross-sectional areas muscle sections 0, 5, 10, 15, 20...