A5018490524- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Surgical site infection prevention
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Bone health and treatments
- Infectious Diseases and Tuberculosis
- Surgical Sutures and Adhesives
- Bone and Joint Diseases
- Bacterial biofilms and quorum sensing
- Wound Healing and Treatments
- Knee injuries and reconstruction techniques
- Advanced materials and composites
- Connective tissue disorders research
- Antimicrobial Resistance in Staphylococcus
- Blood transfusion and management
- Tracheal and airway disorders
- Pelvic and Acetabular Injuries
- Fibroblast Growth Factor Research
- Italian Literature and Culture
- Elbow and Forearm Trauma Treatment
- Antimicrobial agents and applications
Hospital for Special Surgery
2016-2025
Stavros
2021-2025
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Cornell University
2015-2023
Mathematica Policy Research
2023
Heraeus (Germany)
2023
University of Missouri–St. Louis
2023
Philadelphia University
2023
Ospedale Santa Chiara
2022
Background: The aim of this study was to analyze NSQIP (National Surgical Quality Improvement Program) data better understand the incidence, risk factors, and thirty-day complication rates associated with transfusions in primary total hip knee arthroplasty. Methods: We identified 9362 13,662 arthroplasty procedures from database separated those which any red blood-cell transfusion performed within seventy-two hours after surgery no transfusion. Patient demographics, comorbidities,...
The inability to effectively treat biofilm-related infections is a major clinical challenge. This has been attributed the heightened antibiotic tolerance conferred bacterial cells embedded within biofilms. Lytic bacteriophages (phages) have evolved infect and eradicate biofilm-associated cells. current study was designed investigate ability of phage treatment enhance activity antibiotics against biofilm-forming Staphylococcus aureus. biofilm positive S. aureus strain ATCC 35556, lytic...
Abstract Antibiotic‐loaded bone cement (ALBC) is broadly used to treat orthopaedic infections based on the rationale that high‐dose local delivery essential eradicate biofilm‐associated bacteria. However, ALBC formulations are empirically drug susceptibility from routine laboratory testing, which known have limited clinical relevance for biofilms. There also dosing concerns with nonstandardized, surgeon‐directed, hand‐mixed formulations, unknown release kinetics. On basis of our knowledge in...
Background: Periprosthetic joint infection (PJI) is a devastating complication following total arthroplasty. Current animal models of PJI are limited because lack quantitative methods and failure to effectively recreate the periprosthetic space. We therefore developed murine model involving 3-dimensionally printed Ti-6Al-4V implant capable bearing weight permitting analysis bacterial load evaluation biofilm. Methods: Twenty-five 12-week-old C57BL/6 mice received unilateral proximal tibial...
Aims This study aims to: determine the difference in pelvic position that occurs between surgery and radiographic, supine, postoperative assessment; examine how influences subsequent component orientation; establish whether differences position, thereafter orientation, exist total hip arthroplasties (THAs) performed supine versus lateral decubitus positions. Patients Methods The intra- anteroposterior radiographs of 321 THAs were included; 167 with patient using anterior approach 154...
Aims Current treatments of prosthetic joint infection (PJI) are minimally effective against Staphylococcus aureus biofilm. A murine PJI model debridement, antibiotics, and implant retention (DAIR) was used to test the hypothesis that PlySs2, a bacteriophage-derived lysin, can target S. biofilm address unique challenges presented in this periprosthetic environment. Methods The ability PlySs2 vancomycin kill colony-forming units (CFUs) on orthopaedic implants were compared using vitro models....
ABSTRACT Introduction: Prosthetic joint infection (PJI) after total hip and knee arthroplasty (TJA) is a major cause of morbidity in orthopedics. Fully specified quality measures for PJI diagnosis are lacking. We aimed to specify evaluate electronic clinical (eCQM) across different healthcare institutions. Methods: Measures were using an iterative process through which elements the identified evaluated, their capture optimized health record (EHR). then retrospectively tested at three...
A 68-year-old woman with a well-functioning total knee replacement presented signs and symptoms of acute periprosthetic joint infection (PJI). Lyme serology synovial fluid PCR were performed due to Borrelia burgdorferi. The patient was treated oral doxycycline, had prompt resolution symptoms, remained asymptomatic 2 years later. PJI may be underappreciated as cause culture-negative PJI, cannot diagnosed in routine culture, can cured without surgery.
Abstract Background Periprosthetic joint infection (PJI) is one of the most devastating complications total arthroplasty. Given mortality and morbidity associated with PJI challenges in treating it, there has been increased interest risk factors that can be modified before surgery. In this study, we used a novel mouse model to consider role gut microbiome as factor for PJI. Questions/purposes (1) Does state microbiota surgery influence likelihood developing an established PJI? (2) How does...
BackgroundAlthough preventive strategies have been proposed against catheter-associated urinary tract infections (CAUTIs) in intensive care units (ICUs), more efforts are needed to control the incidence rate.AimTo distinguish patients according their characteristics at ICU admission, and identify clusters of higher risk for CAUTIs.MethodsA two-step cluster analysis was conducted on 9656 from Italian Nosocomial Infections Surveillance Intensive Care Units project.FindingsThree were...
Background: Periprosthetic joint infection (PJI) remains a devastating complication following total arthroplasty. Current animal models of PJI do not effectively recreate the clinical condition and thus provide limited help in understanding why treatments fail. We developed mouse model first-stage surgery 2-stage revision for involving 3-dimensionally printed Ti-6Al-4V implant mouse-sized cement spacer that elutes vancomycin. Methods: Vancomycin was mixed with polymethylmethacrylate (PMMA)...
Background: Over 1 million Americans undergo joint replacement each year, and approximately in 75 will incur a periprosthetic infection. Effective treatment necessitates pathogen identification, yet standard-of-care cultures fail to detect organisms 10% 20% of cases require invasive sampling. We hypothesized that cell-free DNA (cfDNA) fragments from microorganisms infection can be found the bloodstream utilized accurately identify pathogens via next-generation sequencing. Methods: In this...
The use of computer navigation or robotic assistance during primary total hip arthroplasty (THA) has yielded numerous benefits due to more accurate component positioning. utilization these tools is generally associated with longer operative times and also necessitates additional surgical equipment personnel in the operating room. Thus, aim this study was evaluate impact technology on periprosthetic joint infection (PJI) after THA.