A5091779709- Orthopedic Infections and Treatments
- Urological Disorders and Treatments
- Antimicrobial Resistance in Staphylococcus
- Orthopaedic implants and arthroplasty
- Infectious Diseases and Tuberculosis
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Diabetic Foot Ulcer Assessment and Management
- Total Knee Arthroplasty Outcomes
- Bladder and Urothelial Cancer Treatments
- Neonatal and Maternal Infections
- Pediatric Urology and Nephrology Studies
- Hormonal and reproductive studies
- Digital Imaging in Medicine
- Prostate Cancer Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Hernia repair and management
- Cancer-related Molecular Pathways
- Vascular Malformations and Hemangiomas
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Urologic and reproductive health conditions
- Bacterial biofilms and quorum sensing
- Wound Healing and Treatments
- Ocular Infections and Treatments
University of Rochester
2016-2023
University of Rochester Medical Center
2018-2020
Although Staphylococcus aureus osteomyelitis is considered to be incurable, the major bacterial reservoir in live cortical bone has remained unknown. In addition biofilm bacteria on necrotic tissue and implants, studies have implicated intracellular infection of osteoblasts osteocytes as a mechanism chronic osteomyelitis. Thus, we performed first systematic transmission electron microscopy (TEM) formally define reservoirs S. chronically infected mouse (Balb/c J) long tissue. rare, evidence...
Abstract Antibiotic‐loaded bone cement (ALBC) is broadly used to treat orthopaedic infections based on the rationale that high‐dose local delivery essential eradicate biofilm‐associated bacteria. However, ALBC formulations are empirically drug susceptibility from routine laboratory testing, which known have limited clinical relevance for biofilms. There also dosing concerns with nonstandardized, surgeon‐directed, hand‐mixed formulations, unknown release kinetics. On basis of our knowledge in...
Management of foot salvage therapy (FST) for diabetic infections (DFI) is challenging due to the absence reliable diagnostics identify etiologic agent and prognostics justify aggressive treatments. As Staphylococcus aureus most common pathogen associated with DFI, we aimed develop a multiplex immunoassay IgG in serum medium enriched newly synthesized anti-S. antibodies (MENSA) generated from cultured peripheral blood mononuclear cells DFI patients undergoing FST. Wound samples were collected...
Osteomyelitis is a chronic bone infection that often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which attributed the poor performance PMMA as drug release device. Hence, objective this study was design and evaluate bioresorbable calcium phosphate scaffold (CaPS) for sustained antimicrobial investigate its efficacy murine model femoral...
Scrotal ulceration after hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C (MMC) is a rare but severe complication. This case report of patient presenting painful nonhealing scrotal 2 treatments HIPEC MMC. After failing conservative management, biopsy demonstrated thrombosis adjacent vessels. Excision the affected area scrotoplasty completely resolved his pain. debilitating While preventative measures are not well understood, early recognition and surgical excision can lead...
Introduction and Objective: Holmium laser enucleation of the prostate (HoLEP) is often offered for symptomatic prostatic enlargement at high risk bleeding. However, prior studies define clinically significant hematuria (CSH) narrowly as need blood transfusion or decrease in hemoglobin. We sought to evaluate factors contributing a broader definition CSH, which may contribute alteration clinical course. Methods: analyzed 164 patients prospectively maintained database who underwent HoLEP single...
Staphylococcus aureus and Streptococcus agalactiae (Group B streptococcus, GBS) are common causes of deep musculoskeletal infections (MSKI) result in significant patient morbidity cost to the healthcare system. One major challenges with MSKI is lack faithful diagnostics correctly identify primary pathogen, as standard culture-based assays prone false positives case polymicrobial infections, negatives due limitations sample acquisition antibiotic use before presentation. To improve upon our...
You have accessJournal of UrologyHealth Services Research: Quality Improvement & Patient Safety II (MP33)1 May 2024MP33-05 SINGLE-USE CYSTOSCOPES OFFERS FASTER TIME-TO-SCOPE WITH EQUIVALENT PERCEIVED FUNCTIONALITY VS REUSABLE SCOPES IN THE INPATIENT SETTING Stephen Hassig, Matthew Steidle, Carl Ceraolo, Jason Fairbourn, Denzel Zhu, Ashley Li, Galen Chen, Kelvin Lim, Christopher Wanderling, Aaron Saxton, Laena Hines, Trevor Hunt, Mark Ninomiya, Austin Lee, Rajat Jain, and Scott O. Quarrier...
Background: Conventional bacterial cultures frequently fail to identify the dominant pathogen in polymicrobial foot infections, which Staphylococcus aureus is most common infecting pathogen. Previous work has shown that species-specific immunoassays may be able main musculoskeletal infections. We sought investigate clinical applicability of a S. immunoassay accurately and monitor its infectivity longitudinally infection. hypothesized this could aid diagnosis track therapeutic response...
Objectives Surgical techniques to repair a ureteral stricture may depend on the stricture’s etiology, length, and location. Options range from primary reimplantation for short, distal strictures, buccal mucosa onlay ureteroplasty complex proximal or mid defects, Boari flap even autotransplantation longer defects. Replacement of entire ureter with segment ileum is rare but provide durable results when indicated. Our objective was illustrate how history evolution ileal entered contemporary...
You have accessJournal of UrologyCME1 Apr 2023HF01-15 THE ILEAL URETER: OVER A CENTURY OF UROLOGIC INNOVATION Mark Ninomiya, Linda Hasman, Ronald Rabinowitz, and Divya Ajay NinomiyaMark Ninomiya More articles by this author , HasmanLinda Hasman RabinowitzRonald Rabinowitz AjayDivya View All Author Informationhttps://doi.org/10.1097/JU.0000000000003243.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION...
You have accessJournal of UrologyCME1 Apr 2023MP49-12 ADVANCING COMPREHENSIVE URO-ONCOLOGIC CARE FOR THE URBAN UNDERSERVED Kit Yuen, Alexis Steinmetz, Mark Ninomiya, and Divya Ajay YuenKit Yuen More articles by this author , SteinmetzAlexis Steinmetz NinomiyaMark Ninomiya AjayDivya View All Author Informationhttps://doi.org/10.1097/JU.0000000000003297.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION...
You have accessJournal of UrologyCME1 Apr 2023MP59-14 REDEFINING CLINICALLY SIGNIFICANT HEMATURIA AFTER HOLMIUM ENUCLEATION OF THE PROSTATE Laena Hines, Karen Doersch, Mark Ninomiya, Rajat Jain, and Scott O Quarrier HinesLaena Hines More articles by this author , DoerschKaren Doersch NinomiyaMark Ninomiya JainRajat Jain QuarrierScott View All Author Informationhttps://doi.org/10.1097/JU.0000000000003312.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...