A5040594375- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Peroxisome Proliferator-Activated Receptors
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Connective tissue disorders research
- Fibroblast Growth Factor Research
- Bone fractures and treatments
- Phytochemicals and Antioxidant Activities
- RNA modifications and cancer
- Antimicrobial Resistance in Staphylococcus
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Knee injuries and reconstruction techniques
- Esophageal Cancer Research and Treatment
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Brain Metastases and Treatment
- Phytoestrogen effects and research
- Molecular Biology Techniques and Applications
- Tea Polyphenols and Effects
- Radiomics and Machine Learning in Medical Imaging
- Liver Diseases and Immunity
- Mesenchymal stem cell research
National Cancer Institute
2024
National Institutes of Health
2024
Center for Cancer Research
2024
Longyan University
2023-2024
Zunyi Medical University
2024
First People’s Hospital of Zunyi
2024
University of Rochester
2016-2017
University of Rochester Medical Center
2014-2016
Institute of Biophysics
2006
Zhejiang University
2006
Although Staphylococcus aureus osteomyelitis is considered to be incurable, the major bacterial reservoir in live cortical bone has remained unknown. In addition biofilm bacteria on necrotic tissue and implants, studies have implicated intracellular infection of osteoblasts osteocytes as a mechanism chronic osteomyelitis. Thus, we performed first systematic transmission electron microscopy (TEM) formally define reservoirs S. chronically infected mouse (Balb/c J) long tissue. rare, evidence...
Esophageal cancer (EC) is a common form of malignant tumor in the digestive system that classified into two types: squamous cell carcinomas (ESCC) and esophageal adenocarcinoma. ESCC known for its early onset symptoms, which can be difficult to identify, as well rapid progression tendency develop drug resistance chemotherapy radiotherapy. These factors contribute high incidence disease low cure rate. Therefore, diagnostic biomarker therapeutic target need identified ESCC. Non‑coding RNAs...
In the present study, we successively extracted Pu-erh tea with acetone, water, chloroform, ethyl acetate, and n-butanol, extracts were then isolated by column chromatography. Our study demonstrates that acetate extract, n-butanol their fractions had superoxide anion hydroxyl radical scavenging activity: 2 8 from extract 2, 4, 5 showed protective effects against hydrogen peroxide-induced damage in human fibroblast HPF-1 cells increased cells' viability under normal cell culture conditions....
Histomorphometric analysis of histologic sections normal and diseased bone samples, such as healing allografts fractures, is widely used in research. However, the utility traditional semi-automated methods limited because they are labor-intensive can have high interobserver variability depending upon parameters being assessed, primary data cannot be re-analyzed automatically. Automated histomorphometry has long been recognized a solution for these issues, recently become more feasible with...
Investigations of teriparatide (recombinant parathyroid hormone [rPTH]) as a potential treatment for critical defects have demonstrated the predicted anabolic effects on bone formation, and significant non-anabolic healing via undefined mechanisms. Specifically, studies in murine models structural allograft that rPTH increased angiogenesis (vessels <30 μm), decreased arteriogenesis (>30 μm) mast cell numbers, which lead to fibrosis accelerated healing. To better understand these effects, we...
A unique population of CD23 + CD21 high B cells in i nflamed n odes (Bin) has been shown to accumulate lymph nodes (LNs) draining inflamed joints TNF‐transgenic (TNF‐tg) mice. Bin contribute arthritis flare mice by distorting node architecture and hampering lymphatic flow, but their existence human LNs not yet described. Here, we report the characterization resident B‐cell populations fresh popliteal (PLNs) from patients with severe lower limb diseases (non‐RA) rheumatoid (RA) patients,...
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes severe inflammatory response, disease sow failure. Quercetin is among the widely occurring polypheno found abundantly in nature. has anti‐inflammatory, anti‐oxidative anti‐viral properties. Objectives This study aimed to explore effect mechanism of quercetin on PRRSV‐induced inflammation MARC‐145 cells. Methods Observing cytopathic measurements markers cells collectively demonstrate that elicits...
Glioma is the most prevalent type of primary central nervous system cancer, while glioblastoma (GBM) its aggressive variant, with a median survival only 15 months when treated maximal surgical resection followed by chemoradiation therapy (CRT). CD133 potentially significant GBM biomarker. However, current clinical biomarker studies rely on invasive tissue samples. These make prolonged data acquisition impossible, resulting in increased interest use liquid biopsies. Our study, analyzed 7289...
Glioblastoma (GBM) is a highly malignant and devastating brain cancer characterized by its ability to rapidly aggressively grow, infiltrating tissue, with nearly universal recurrence after the standard of care (SOC), which comprises maximal safe resection followed chemoirradiation (CRT). The metabolic triggers leading reprogramming tumor behavior resistance are an area increasingly studied in relation molecular features associated outcome. There currently no metabolomic biomarkers for GBM....
Although most fractures heal, critical defects in bone fail due to aberrant differentiation of mesenchymal stem cells towards fibrosis rather than osteogenesis. While conventional bioengineering solutions this problem have focused on enhancing angiogenesis, which is required for formation, recent studies shown that fibrotic non-unions are associated with arteriogenesis the center defect and accumulation mast around large blood vessels. Recently, recombinant parathyroid hormone (rPTH;...
Gliomas are the most common malignant brain tumors, with complicated etiology and poor prognosis. However, there is still a lack of specific biomarkers for diagnosis, treatment prognosis assessment glioma patients. Hence, purpose this study was to screen prognostic therapeutic interventions in gliomas.
<title>Abstract</title> Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes severe inflammatory response disease. Quercetin is among the widely occurring polyphenol, found abundantly in nature. has anti-inflammatory, anti-oxidative anti-viral properties. This study aimed to explore effect mechanism of quercetin on PRRSV induced inflammation MARC-145 cells. Observing cytopathic measurements markers cells collectively demonstrate that elicits a curative PRRSV-induced...
Fracture repair requires angiogenesis and osteogenesis.However, the imaging method of dynamic longitudinal observation osteogenesis in long bone fracture living animals is lacking.Here we developed a Multiphoton Laser Scanning Microscopy (MPLSM) protocol for detecting fluorescence labeled mesenchymal progenitor cells blood vessels tibial callus Nestin-GFP mice.We validated our MPLSM results using conventional histological method.MPLSM showed same changes Nestin-GFP+ (volume, length...