A5100453530- Glaucoma and retinal disorders
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Bone health and treatments
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Spinal Fractures and Fixation Techniques
- Corneal Surgery and Treatments
- Bone Tissue Engineering Materials
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- MicroRNA in disease regulation
- Facial Nerve Paralysis Treatment and Research
- Retinal Imaging and Analysis
- Pharmacological Effects of Medicinal Plants
- Scoliosis diagnosis and treatment
- Trigeminal Neuralgia and Treatments
- Musculoskeletal pain and rehabilitation
- Traumatic Ocular and Foreign Body Injuries
- Pelvic and Acetabular Injuries
- Tea Polyphenols and Effects
- Veterinary Orthopedics and Neurology
Shanghai Mental Health Center
2012-2024
Second Hospital of Anhui Medical University
2022-2024
Queen's University
2024
Shanghai Jiao Tong University
2012-2024
University of Auckland
2019-2023
Cell Technology (China)
2023
Beijing Tongren Hospital
2009-2023
He Eye Hospital
2023
Anhui Provincial Children's Hospital
2023
Hainan Medical College Hospital
2022
The purpose of this study was to explore incidence and risk factors adjacent segment disease (ASD) following posterior decompression instrumented fusion for degenerative lumbar disorders, hope provide references in decision making surgical planning both spinal surgeon surgically treated patients. By retrieving the medical records from January 2011 December 2013 our hospital, 237 patients were retrospectively reviewed. According occurrence ASD at follow up, divided into 2 groups: N-ASD group....
ABSTRACT Osteoporosis is an osteolytic disease that features enhanced osteoclast formation and bone resorption. Identification of agents can inhibit function important for the treatment osteoporosis. Dihydroartemisinin a natural compound used to treat malaria but its role in osteoporosis not known. Here, we found dihydroartemisinin suppress RANKL-induced osteoclastogenesis resorption dose-dependent manner. inhibited expression marker genes such as cathepsin K, calcitonin receptor,...
In this study, a biodegradable thermo-sensitive hydrogel from poly(trimethylene carbonate)15-F127-poly(trimethylene carbonate)15 (PTMC15-F127-PTMC15) was designed and evaluated as an injectable implant during ocular glaucoma filtration surgery in vivo vitro. Mitomycin C (MMC) loaded into for controlled released to prolong the efficacy reduce long-term toxicity. The properties of were confirmed using 1H NMR gel permeation chromatography (GPC). Compared Pluronic F127 hydrogel,...
Over‐production and activation of osteoclasts is a common feature osteolytic conditions such as osteoporosis, tumor‐associated osteolysis, inflammatory bone erosion. Cyanidin Chloride, subclass anthocyanin, displays antioxidant anti‐carcinogenesis properties, but its role in osteoclastic resorption osteoporosis not well understood. In this study, we showed that Chloride inhibits osteoclast formation, hydroxyapatite resorption, receptor activator NF‐κB ligand (RANKL)‐induced marker gene...
ABSTRACT Insulin-like growth factors (IGFs) are important local regulators during fracture healing. Although IGF1 deficiency is known to increase the risk of delayed union or non-union fractures in elderly population, underlying mechanisms that contribute this defect remains unclear. In study, signaling healing was investigated an osteoblast-specific receptor (IGF1R) conditional knockout (KO) mouse model. A closed tibial induced IGF1Rflox/flox/2.3-kb α1(1)-collagen-Cre and IGF1Rflox/flox...
To investigate the structures and neural changes in cryptococcal meningitis (CM) patients compared with healthy controls. Retrospective, cross-sectional, cohort study. Seventy-six eyes of 39 CM were included this observational clinical Thirty 16 papilledema Group 1, 46 23 without 2. Another 80 40 participants 3 as Optical coherence tomography (OCT) images obtained from all via a DRI OCT Triton 3D device its prototype IMAGEnet 6 for software. Compared those controls, peripapillary retinal...
Abstract Prostate cancer cells often metastasize to bone where osteolytic lesions are formed. Runx2 is an essential transcription factor for formation and suppresses cell growth in normal osteoblasts but may function as oncogenic solid tumors (e.g., breast, prostate). Here, we addressed whether linked steroid hormone signaling, which controls prostate growth. Protein expression profiling of lines (i.e., PC3, LNCaP, RWPE) treated with 5α‐dihydrotestosterone (DHT) or tumor β (TGFβ) revealed...
Follicular helper T (Tfh) cells and follicular regulatory (Tfr) are critical for the development maintenance of germinal centre (GC) humoral immune responses. Accumulating evidence has demonstrated that dysregulation either Tfh or Tfr contributes to pathogenesis autoimmune diseases. We aim investigate roles circulating in primary biliary cholangitis (PBC). A total 34 patients with PBC 27 health individuals were enrolled this study. Flow cytometry revealed (CD4+ CXCR5+ CD127hi CD25lo )...
Investigations of teriparatide (recombinant parathyroid hormone [rPTH]) as a potential treatment for critical defects have demonstrated the predicted anabolic effects on bone formation, and significant non-anabolic healing via undefined mechanisms. Specifically, studies in murine models structural allograft that rPTH increased angiogenesis (vessels <30 μm), decreased arteriogenesis (>30 μm) mast cell numbers, which lead to fibrosis accelerated healing. To better understand these effects, we...
Autologous bone marrow mesenchymal stem cell (BMSC)–calcium phosphate ceramic composites were constructed in vitro and implanted as a graft substitute for lumbar anterior interbody fusion rhesus monkeys to determine the osteogenic capacity of composites. Nine adult underwent L3–L4 L5–L6 diskectomy via an retroperitoneal approach. Two sites each animal randomly assigned two three treatments: autogenous tricortical iliac crest (autograft group), cell-free (ceramic or BMSC–ceramic composite...
Anesthetized dogs were scanned in the dynamic spatial reconstructor, a fast multislice computed tomographic scanner. In one group of eight dogs, four differently radiolabeled microspheres (1.5 mu m diameter) injected into left atrium, with each label corresponding to different hemodynamic condition. The image data collected from this used develop algorithm for estimating regional myocardial perfusion CT data. an additional 11 three labeled also during conditions. second prospectively...
The present study aimed to screen several differentially expressed genes (DEGs) and microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP‑6) dexamethasone were used induce MSCs towards osteoblastic differentiation or adipocytic t‑test in the Bioconductor bioinformatics software tool was DEGs miRNAs samples. Subsequent gene ontology (GO) pathway analyses on performed using GO Kyoto Encyclopedia Genes Genomes databases, respectively;...
Curcumin can inhibit the osteoclastogenesis and migration of several cells including macrophages. Osteoclast precursors (OCPs) are known to exist as bone marrow-derived macrophages (BMMs). This study aims explore whether curcumin prevent fusion differentiation OCPs mature osteoclasts by inhibiting OCP migration.