A5101525756- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Pregnancy-related medical research
- NF-κB Signaling Pathways
- Pelvic and Acetabular Injuries
- Spinal Hematomas and Complications
- Cell Adhesion Molecules Research
- Shoulder Injury and Treatment
- MicroRNA in disease regulation
- Orthopaedic implants and arthroplasty
- Immune Response and Inflammation
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
- Healthcare and Venom Research
- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Management of metastatic bone disease
- Sports injuries and prevention
- Nausea and vomiting management
- Spinal Cord Injury Research
- Lower Extremity Biomechanics and Pathologies
Hebei Medical University
2015-2025
Third Hospital of Hebei Medical University
2015-2025
Weatherford College
2016-2017
Johns Hopkins University
2016
National Natural Science Foundation of China
2014
Sun Yat-sen Memorial Hospital
2000
Sun Yat-sen University
2000
The purpose of this study was to explore incidence and risk factors adjacent segment disease (ASD) following posterior decompression instrumented fusion for degenerative lumbar disorders, hope provide references in decision making surgical planning both spinal surgeon surgically treated patients. By retrieving the medical records from January 2011 December 2013 our hospital, 237 patients were retrospectively reviewed. According occurrence ASD at follow up, divided into 2 groups: N-ASD group....
Abstract Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis associated with IVD, however the pathogenesis hypertrophy poorly understood. Here, we employed two spine instability mouse models to investigate temporal and spatial changes volume, considering them as functional unit. We found that aberrant mechanical loading leads accelerated ossification EP, decreased volume increased activation TGFβ. Overexpression active TGFβ in CED mice showed...
The aim of this study was to identify the prevalence proximal junctional kyphosis (PJK) in degenerative lumbar scoliosis (DLS) following long instrumented posterior spinal fusion, and search for predictable risk factors progression kyphosis. In total 98 DLS patients with a minimum 2-year follow-up were reviewed prospectively. According occurrence PJK at last follow-up, divided into 2 groups: group non-PJK group. To investigate values PJK, 3 categorized analyzed statistically: patient...
Abstract Skeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2) concentration in bone. Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration aging. We found that PGE2 was elevated to generate spinal pain. Importantly, treatment with a high-dose cyclooxygenase 2 inhibitor (celecoxib, 80 mg·kg −1 per day) decreased attenuated pain mice lumbar spine instability. However, this impaired formation endplates,...
In previous studies, both 17β-estradiol (E2) and resveratrol (RES) were reported to protect intervertebral disc cells against aberrant apoptosis. Given that E2 has a better anti-apoptotic effect with more cancer risk RES an less risk, the combined use of is promising in developing clinical therapies treat apoptosis-related diseases such as degeneration future.The purpose this study was explore on rat nucleus pulposus underlying mechanisms.TUNEL assay FACS analysis used determine apoptotic...
This study aimed to investigate the protective effect of adipose tissue-derived exosomes (AT-Exo) on rat nucleus pulposus cells (NPCs). Ultracentrifugation was used extract from tissue. Transmission electron microscopy (TEM), Western blot, and nanoparticle tracking analysis (NTA) were characterize exosomes. Tert-butyl hydrogen peroxide (TBHP) induce apoptosis NPCs. Cell viability determined by CCK-8 assay. AT-Exo administered its NPCs using blot immunofluorescence staining. successfully...
A multicenter retrospective study.The purpose of this study was to explore risk factors dysphagia after anterior cervical surgery and affecting rehabilitation 2 years surgery.Patients who underwent at 3 centers from January 2010 2013 were included. The possible included aspects: demographic variables-age, sex, body mass index (BMI): hypertension, diabetes, heart disease, smoking, alcohol use, diagnose (cervical spondylotic myelopathy or ossification posterior longitudinal ligament),...
This study was aimed to further explore whether estradiol (E2) had protective effects on intervertebral disc degeneration (IVDD) in a rat model.Forty, three-month-old female Sprague Dawley (SD) rats were randomly divided into four groups: Sham, Ovariectomy (OVX), E2 and ICI182780 (ICI). Sham group only underwent the resection of bit fat; OVX bilateral ovariectomy; treated with based OVX; ICI pretreated (inhibitor estrogen receptor) OVX. Radiography, hematoxylin eosin (HE) staining,...
Patients with degenerative lumbar spondylolisthesis (DLS) often suffer from years of low back pain (LBP) due to instability the spine and reduction disc height. Since January 2016, we have performed oblique lateral interbody fusion (OLIF) on 154 patients. Among these, 56 patients who suffered DLS underwent OLIF stand-alone cages. Forty-two a follow-up time that exceeded 1-year were enrolled for this study. The forty-two followed up at least one year. Operation segments ranged L3-4 L4-5. All...
BACKGROUND:The exosomes (Exo) derived from mesenchymal stem cells (MSCs) are capable of attenuating the apoptosis nucleus pulposus (NPCs) elicited by proinflammatory cytokines. However, it remains unknown whether MSC-derived Exo also exert a protective effect on NPCs in pathological acid environment. MATERIAL AND METHODS:NPCs were divided into 3 groups: Group A, pH 7.1–7.3; B, 6.5–6.7 and C, 5.9–6.1. The cultured above-defined acidic medium, different amounts added media. Finally, expression...
Both general anesthesia (GA) and cervical plexus (CPA) can be used for anterior discectomy fusion (ACDF) surgery. The aim of this study was to evaluate the influence anesthetic techniques on perioperative mortality morbidity in patients undergoing From January 2008 December 2015, 356 who underwent 1-level ACDF spinal myelopathy were prospectively reviewed. They assigned receive GA (group A) CPA B). analgesic efficacy block assessed by preparation time, maximum heart rate, mean arterial blood...
BACKGROUND Clinically, percutaneous vertebroplasty (PVP) is frequently applied to treat osteoporotic vertebral compression fracture (OVCF). It believed that new fractures are more likely occur adjacent the PVP-treated segment, typically within 1 month after PVP. The purpose of this study was investigate risk factors for (AVCF) PVP in patients with OVCF menopause. MATERIAL AND METHODS Between Jun 2012 and Dec 2016, 412 were initially identified. We enrolled 390 study, 22 lost follow-up....
The aim of this study was to explore the incidence and risk factors postoperative neurological deterioration after posterior decompression with or without instrumented fusion for thoracic myelopathy, hope provide references in decision-making surgical planning both spinal surgeon stenosis patients.By retrieving medical records from January 2001 November 2015, 168 patients were retrospectively reviewed. According occurrence deterioration, divided into 2 groups: (ND) group non-ND group. To...
Intervertebral disc degeneration (IVDD) is the main pathological basis of spinal degenerative diseases, and aberrant apoptosis nucleus pulposus cells (NPCs) cellular process that causes IVDD. In our previous studies, 17β‑estradiol (E2) was demonstrated to protect rat NPCs from interleukin‑1β (IL‑1β)‑induced via PI3K/Akt signaling pathway. However, downstream pathway currently unclear. The present study aimed explore pathways are pathway, including mTOR, NF‑κB glycogen synthase kinase‑3β...
This study aimed to investigate the effect factors associated with postoperative dissatisfaction of patients undergoing open-door laminoplasty for cervical OPLL.In this study, 194 patients, who underwent OPLL from January 2009 2016, were retrospectively reviewed. The Patient Satisfaction Index (PSI) was collected at discharge, 6 months, 1 year, and last follow-up. According PSI, divided into satisfied group dissatisfied group. possible included demographic variables surgery-related...