A5016750088- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Bone Metabolism and Diseases
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Liver physiology and pathology
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Pregnancy-related medical research
- Signaling Pathways in Disease
- Bone health and osteoporosis research
- Microtubule and mitosis dynamics
- Rheumatoid Arthritis Research and Therapies
Fudan University
2015-2025
Zhongshan Hospital
2015-2025
Ministry of Education of the People's Republic of China
2017-2025
First Affiliated Hospital of GuangXi Medical University
2010-2024
Guangxi Medical University
2013-2024
Cancer Institute (WIA)
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2022
Sun Yat-sen University
2020-2022
The University of Western Australia
2014-2017
Peking University People's Hospital
2001
Osteoarthritis (OA) is a degenerative illness that greatly impacts the life quality of patients. Currently, therapeutic approaches for OA are very limited in clinical. The extracellular vesicles (EVs) derived from different mesenchymal stem cells displayed prominent effect on OA. But most EVs have resources and risks host rejection, immunological response, etc. Human umbilical cord (hUCMSCs) hold advantages easy availability, minimal immune excellent immunomodulatory effects, although...
Abstract Dissecting and understanding the cancer ecosystem, especially that around tumor margins, which have strong implications for cell infiltration invasion, are essential exploring mechanisms of metastasis developing effective new treatments. Using a novel border scanning digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq), we identified 500 µm-wide zone centered in patients with liver cancer, referred to as “the invasive zone”. We...
ABSTRACT Osteoporosis is an osteolytic disease that features enhanced osteoclast formation and bone resorption. Identification of agents can inhibit function important for the treatment osteoporosis. Dihydroartemisinin a natural compound used to treat malaria but its role in osteoporosis not known. Here, we found dihydroartemisinin suppress RANKL-induced osteoclastogenesis resorption dose-dependent manner. inhibited expression marker genes such as cathepsin K, calcitonin receptor,...
Abstract Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor derived from bile duct epithelium. Its characteristics include an insidious onset and frequent recurrence or metastasis after surgery. Current chemotherapies molecular target therapies provide only modest survival benefits to patients with ICC. Anlotinib novel multi-target tyrosine kinase inhibitor that has good antitumor effects in variety of solid tumors. However, there are few studies anlotinib-associated mechanisms use...
Abstract Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve patient survival. We aimed to develop a blood‐based assay aid in the diagnosis, detection and prognostic evaluation HCC. Methods A three‐phase multicentre study was conducted screen, optimise validate HCC‐specific differentially methylated regions (DMRs) using next‐generation sequencing quantitative methylation‐specific PCR (qMSP). Results Genome‐wide methylation profiling identify DMRs...
Abstract Rationale CD13 is a new marker for liver cancer stem cells (CSCs) that contributes to sorafenib resistance in hepatocellular carcinoma (HCC). However, the underlying mechanism of HCC remains enigmatic. Methods The expression cell lines and tissues was assayed by RT‐PCR, western‐blot, immunohistochemistry staining. Athymic BALB/c nu/nu mice model used study vivo functions CD13. Clinical significance evaluated Kaplan‐Meier methods. Cellular proliferation rate counting kit‐8 assay...
Abstract Objective Differentiation‐inducing therapy for tumors is a strategy that aims to induce the differentiation and maturation of cancer stem cells (CSCs). The differentiation‐inducing capacity arsenic trioxide (ATO) in hepatocellular carcinoma (HCC) underlying mechanism were previously unknown. Methods In present study, we explored ATO‐induced CSCs HCC by detecting expression CSC‐related markers tumorigenicity variation vivo vitro. We developed combined chemotherapeutic approach...
Over‐production and activation of osteoclasts is a common feature osteolytic conditions such as osteoporosis, tumor‐associated osteolysis, inflammatory bone erosion. Cyanidin Chloride, subclass anthocyanin, displays antioxidant anti‐carcinogenesis properties, but its role in osteoclastic resorption osteoporosis not well understood. In this study, we showed that Chloride inhibits osteoclast formation, hydroxyapatite resorption, receptor activator NF‐κB ligand (RANKL)‐induced marker gene...
Overexpression of the MDM2 oncogene and mutations in p53 tumor suppressor commonly occur hepatocellular carcinoma (HCC) are associated with increased mortality due to this disease. Inhibiting has been demonstrated be a valid approach for treatment HCC. However, most inhibitors evaluated date have designed block binding, limited efficacy against tumors mutant or deficient p53. In present study, we developed novel inhibitor (termed SP141) that direct effects on exerts anti-HCC activity...
// Wei Wang 1,2,* , Jianwen Cheng 3,4,* Jiang-Jiang Qin Sukesh Voruganti 1 Subhasree Nag Jia Fan 3,4 Qiang Gao and Ruiwen Zhang 1,2 Department of Pharmaceutical Sciences, School pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA 2 Cancer Biology Pharmacy, 3 Liver Institute, Zhongshan Hospital, Key Laboratory Carcinogenesis Invasion, Ministry Education, Fudan University, Shanghai, China 4 Institute Biomedical * These authors contributed to this work equally...
The discovery of new therapeutic drugs with the ability preventing inflammation and joint destruction less adverse effects is urgently needed for rheumatoid arthritis (RA). Carnosic acid (CA), a major phenolic compound isolated from leaves Rosemary ( Rosmarinus officinalis L .), has been reported to have antioxidative antimicrobial properties. However, its on RA not elucidated. Here, we investigated CA osteoclasts fibroblast‐like synoviocytes in vitro collagen‐induced (CIA) Wistar rats vivo....
Abstract Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis ICC. Breast cancer type 1 susceptibility protein-associated protein-1 (BAP1) has been reported be a broad-spectrum tumor suppressor in many types, yet its role ICC remains unknown. The aim this study was investigate the clinical implications and biological function BAP1 Our results showed that messenger RNA protein levels...
Abstract Background High rates of postoperative tumor recurrence contribute to poor outcome in hepatocellular carcinoma (HCC). Here, we investigated whether circulating cells (CTCs) status can predict the benefit adjuvant transcatheter arterial chemoembolization (TACE) patients with HCC. Methods The retrospective study enrolled 344 HCC preoperative CTCs analysis. Clinical outcomes including and survival were compared between those who received did not receive TACE. Similar comparisons made...
BackgroundHigh rates of recurrence after resection severely worsen hepatocellular carcinoma (HCC) prognosis. This study aims to explore whether circulating tumor cell (CTC) is helpful in determine the appropriate liver margins for HCC patients.MethodsHCC patients who underwent were enrolled into training (n=117) or validation (n=192) cohorts, then classified as CTC-positive (CTC≥1) CTC-negative (CTC=0). A standardized pathologic sampling method was used cohort quantify microvascular invasion...
In addition to radical resection, liver transplantation (LTx) is an effective treatment for hepatocellular carcinoma (HCC). However, tumor recurrence limits the efficacy of LTx in some patients. This study investigated role 18F-fludeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) predicting prognosis patients with HCC after LTx. A total 278 consecutive who underwent pre-LTx PET/CT were divided into derivation (n = 178) and temporal validation 100) cohorts...
Sorafenib, a multikinase inhibitor, is new standard treatment for patients with advanced hepatocellular carcinoma (HCC).However, resistance to this regimen frequently observed in clinical practice, and the molecular basis of remains largely unknown.Herein, antitumor activity sorafenib was assessed 16 patient-derived xenograft (PDX) models HCC.Gene expression analysis conducted identify factors that promote resistance.Quantitative RT-PCR immunoblotting were used determine gene activation...
Pancreatic ductal adenocarcinoma (PDA) remains a devastating disease worldwide. Although significant improvement has been made in understanding its pathophysiology, only small portion of patients with PDA are likely to benefit from curative surgery and current chemotherapy. Thus, there is an urgent need for developing novel effective therapeutic approaches the treatment PDA. Today, garlic products have become important source compounds cancer. We recently identified active component,...
Osteolytic bone diseases are characterized by excessive osteoclast formation and activation. Protein kinase C (PKC)-dependent pathways regulate cell growth, differentiation apoptosis in many cellular systems, have been implicated cancer development formation. A number of PKC inhibitors with anti-cancer properties developed, but whether they might also influence osteolysis (a common complication invading cancers) is unclear. We studied the effects inhibitor compound, GF109203X on activity,...